Chemical investigation and effects of the tea of Passiflora alata on biochemical parameters in rats

Doyama, Júlio Toshimi; Rodrigues, Hosana Gomes; Novelli, Ethel L. B.; Cereda, Emanuele; Vilegas, Wagner

doi:10.1016/j.jep.2004.06.021

Cited by 47 publications

(40 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Embora de um modo geral o perfil bioquímico dos animais estivesse dentro dos valores de referência, (Doyama et al, 2005) houve exceções para a uréia, ácido úrico, triglicerídeos e AST. A alteração significativa verificada nos níveis plasmáticos de uréia e ácido úrico apenas no grupo tratado com a dose de 150 mg kg -1 do óleo essencial extraído de Citrus limon pode ser inicialmente interpretada como uma alteração renal.…”

Section: Resultados Do Rendimento E Identificação Da Composição Químiunclassified

Constituintes químicos e estudos toxicológicos do óleo essencial extraído das folhas de Citrus limon Burn (Rutaceae)

Campêlo

Feitosa

et al. 2013

Rev. bras. plantas med.

View full text Add to dashboard Cite

RESUMO:A caracterização química do óleo essencial de folhas de Citrus limon (Rutaceae) resultou na identificação de mistura de monoterpenos (limoneno, linalol, cis-óxido de limoneno, trans-óxido de limoneno, citronelal, neral, geranial, nerol e acetato de geranil). As estruturas dos compostos do óleo essencial foram identificadas por GC/MS, por comparação com dados da literatura. Os efeitos da administração crônica oral do óleo essencial de folhas de Citrus limon foram investigados sobre parâmetros bioquímicos e hematológicos em camundongos Swiss machos. Os animais (n = 10/grupo) foram tratados por via oral diariamente durante 30 dias com óleo essencial de folhas de Citrus limon, nas doses de 50, 100 ou 150 mg kg -1 de massa corporal e os parâmetros bioquímicos e hematológicos avaliados. O tratamento não causou nenhuma morte ou toxicidade nos animais. A administração do óleo essencial não alterou os parâmetros bioquímicos e hematológicos e a massa dos órgãos, exceto por diminuição de 21 e 11% em uréia e ácido úrico, respectivamente, e 9%, nos níveis plasmáticos de aspartato transaminase (AST). Para os parâmetros hematológicos, houve pequenas mudanças nas contagens de neutrófilos, linfócitos, eosinófilos e monócitos, mas estes não foram diferentes dos valores de referência. Além disso, houve diminuição significativa nos triglicerídeos detectado nos animais tratados com dose de 150 mg kg -1 de óleo essencial. Em conclusão, a administração crônica de óleo essencial não induziu nenhum efeito de risco na maioria dos parâmetros bioquímicos e hematológicos estudados em camundongos Swiss machos. No entanto, a diminuição dos níveis de uréia e ácido úrico em doses elevadas, sugere um possível efeito de insuficiência renal e aumento no teor de AST, sugerindo possível sobrecarga hepática que deve ser investigada com mais detalhe. Palavras-chave:Citrus limon, óleo essencial, tratamento crônico, hematologia, bioquímica ABSTRACT: Chemical constituents and toxicological studies of the essential oil extracted from Citrus limon Burn (Rutaceae). The chemical characterization of the essential oil of Citrus limon (Rutaceae) leaves resulted in the identification of a mixture of monoterpenes (limonene, linalool, cis-limonene-oxide, trans-limonene-oxide, citronellal, neral, geranial, nerol e geranyl acetate). The structures of the compounds of essential oil were identified by GC/MS by comparison with literature data. The effects of the chronic oral administration of the essential oil of Citrus limon leaves were investigated on biochemical and hematological parameters in male adult Swiss mice. These animals (n=10/group) were orally treated daily for 30 days with essential oil of Citrus limon leaves with doses of 50, 100 or 150 mg kg -1 body weight and the biochemical and hematological parameters were evaluated. The treatment did not cause any deaths or toxicity in the animals. The administration of essential oil did not change biochemical and hematological parameters and organ weight, except for decreases of 21 and 11% in blood urea nit...

show abstract

Section: Resultados Do Rendimento E Identificação Da Composição Químiunclassified

Constituintes químicos e estudos toxicológicos do óleo essencial extraído das folhas de Citrus limon Burn (Rutaceae)

Campêlo

Feitosa

et al. 2013

Rev. bras. plantas med.

View full text Add to dashboard Cite

show abstract

“…The beneficial effect in HDL-c levels may be attributed to the presence of flavonoids in this species. 18 Investigation using P. alata showed altered HDL-c levels in rats, but it did not show changes in LDL-c levels. 18 This explanation might be extended to the decreased FFA and cholesterol levels in the animals treated with plant juice (Table 1).…”

Section: Discussionmentioning

confidence: 96%

“…18 Investigation using P. alata showed altered HDL-c levels in rats, but it did not show changes in LDL-c levels. 18 This explanation might be extended to the decreased FFA and cholesterol levels in the animals treated with plant juice (Table 1). Nevertheless, treatment with P. edulis did not significantly modify the concentrations of triglycerides and VLDL-c. Other authors have suggested that the insoluble fiber-rich fraction prepared from P. edulis could potentially be hypocholesterolemic.…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Effects ofPassiflora edulis(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Souza

Barbalho

Damasceno

et al. 2012

Journal of Medicinal Food

View full text Add to dashboard Cite

The aim of this study was to evaluate the effects of Passiflora edulis f. flavicarpa Degener (yellow passion) juice on the lipid profile and oxidative stress status of Wistar rats. Adult male Wistar rats were divided in two groups (n = 8 animals per group): the control group, which received water, and the treated group, which was given P. edulis juice (1,000 mg/kg). Both groups received by gavage treatment twice a day for 28 days. The treated group showed an increased high-density lipoproteincholesterol level and decreased low-density lipoprotein-cholesterol and free fatty acid levels compared with the control group. Levels of triglycerides and and very low-density lipoprotein-cholesterol, superoxide dismutase activity, and total glutathione concentration were not statistically different between the two groups, but the thiobarbituric acid-reactive substances concentration (indicating lipid peroxidation) decreased in the treated group. These findings suggests that P. edulis juice in the experimental conditions used showed beneficial effects on lipid profile and improved lipid peroxidation in Wistar rats.

show abstract

“…Flavonoids may act in distinct ways on various components of plasma lipid (DOYAMA et al, 2005), but the available literature still does not suffice to explain the exact mechanisms whereby phenolic acids, flavonoids and terpenoids exert these beneficial effects. Nor does it explain the reasons why they may have positive effects on the reduction of BMI.…”

Section: Biochemical Measurementsmentioning

confidence: 99%

Investigation of the effects of peppermint (Mentha piperita) on the biochemical and anthropometric profile of university students

Barbalho¹,

Farinazzi-Machado²,

Oshiiwa³

et al. 2011

Ciênc. Tecnol. Aliment.

View full text Add to dashboard Cite

Chemical investigation and effects of the tea of Passiflora alata on biochemical parameters in rats

Cited by 47 publications

References 17 publications

Constituintes químicos e estudos toxicológicos do óleo essencial extraído das folhas de Citrus limon Burn (Rutaceae)

Constituintes químicos e estudos toxicológicos do óleo essencial extraído das folhas de Citrus limon Burn (Rutaceae)

Effects ofPassiflora edulis(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Investigation of the effects of peppermint (Mentha piperita) on the biochemical and anthropometric profile of university students

Contact Info

Product

Resources

About