Chemical Evaluation, In Vitro and In Vivo Anticancer Activity of Lavandula angustifolia Grown in Jordan

Aboalhaija, Nour; Syaj, Heba; Afifi, Fatma U.; Sunoqrot, Suhair; Al‐Shalabi, Eveen; Talib, Wamidh H.

doi:10.3390/molecules27185910

Cited by 8 publications

(5 citation statements)

References 28 publications

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“…However, the only route of administration that decreased all measured parameters, including creatinine, was intraperitoneal administration. Our results are in agreement with the results reported in the scientific literature, namely the lack of hepatic and renal adverse effects following lavender oil administration [ 34 , 35 ].…”

Section: Discussionsupporting

confidence: 93%

Anti-inflammatory and antioxidant efficacy of lavender oil in experimentally induced thrombosis

et al. 2023

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Background Lavender oil (LO) possesses anti-inflammatory, antioxidant, antifungal, antibacterial, sedative, cardio-protective, and antinociceptive properties. Thrombosis and inflammation are interplayed processes that interact and influence one another. Our research compared three routes of administration to assess the efficacy of pretreatment with LO on carrageenan-induced thrombosis in rat tail. Materials and methods Wistar-Bratislava white rats were randomly divided into five groups of ten rats each and pretreated 3 consecutive days prior the inducement of thrombosis to with one dose of LO (150 mg/kg body weight (b.w.)): per os by gavage (TLOPO group), intraperitoneal (TIPLO group) and subcutaneous (TSCLO group). We also have a control (C, received saline solution 0.9% and DMSO (vehicle) 1 ml intraperitoneal (i.p.)) group and a group with thrombosis (T group, received saline solution 0.9% plus vehicle 1 ml i.p.). Histopathological examinations were conducted together with measurements of the circulating levels of three oxidative stress markers, antioxidant effect (TAC and THIOL), and three proinflammatory cytokines (TNF- α, RANTES, and MCP-1). Results When administered intraperitoneally, lavender oil has the best efficacy on circulating levels of oxidative stress parameters (MDA, NOx, TOS), one oxidative stress marker (THIOL), and all studied proinflammatory cytokines (p-values < 0.02). Moreover, TIPLO displayed the closest values for bleeding and clotting time to the C group, as well as the lowest length of the thrombus than the T, TPOLO, and TSCLO groups (p-values < 0.001). The TIPLO group has histological appearance comparable to the C group, with the exception of the presence of oedema. Conclusions Lavender oil pretreatment with intraperitoneal administration as three days, one-dose per day, showed anti-inflammatory and antioxidant efficacy in experimentally induced thrombosis.

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Section: Discussionsupporting

confidence: 93%

Anti-inflammatory and antioxidant efficacy of lavender oil in experimentally induced thrombosis

et al. 2023

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“…Secondary metabolites are crucial components found in medicinal plants. They offer many benefits, such as managing diseases in plants and humans, producing pharmaceutical drugs, and formulating cosmetics [22] …”

Section: Resultsmentioning

confidence: 99%

“…They offer many benefits, such as managing diseases in plants and humans, producing pharmaceutical drugs, and formulating cosmetics. [22] The chemical composition of plants is known to vary widely, even within the same species. These variations in the chemical profile are closely linked to several factors that can significantly affect the plant extract's yield, composition, and biological properties.…”

Section: Phytochemical Analysismentioning

confidence: 99%

Chemical Composition, Antioxidant, and Antibacterial Activity of Ruta chalepensis L. Ethanolic Extract

Althaher,

Oran,

Awadallah

et al. 2024

Chemistry & Biodiversity

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Ruta chalepensis L. is a versatile herb used in culinary arts and traditional medicine. The study aimed to determine the chemical composition of an ethanolic extract from R. chalepensis and the total phenolic and flavonoid content. Additionally, the extracts' antimicrobial and antioxidant activities were tested. The disc diffusion method and minimum inhibitory concentration (MIC) were used to test the antibacterial properties on four types of bacteria: Escherichia coli, Proteus penneri, Bacillus cereus, and Staphylococcus aureus. A colorimetric assay was used to evaluate the total phenolic and flavonoid content, and the DPPH method was used to assess the antioxidant activity. The phytochemical constituents were determined using LC‐MS/MS. The results indicated that R. chalepensis ethanolic extract had 34 compounds, and the predominant compounds were quercetin (9.2%), myricetin (8.8%), and camphene (8.0%). Moreover, the extract had a good level of polyphenols and flavonoids, as demonstrated by inhibiting free radicals (DPPH) (IC50 was 41.2±0.1). Also, the extract exhibited robust antimicrobial activity against P. penneri and S. aureus with an MIC of 12.5 and 25.0 μg/mL, respectively. In conclusion, the results suggest that the R. chalepensis ethanolic extract has good antioxidant and antibacterial properties that could be utilized to develop new antibacterial agents.

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“…Final well concentrations for all compounds were 100, 50, 25, 12.5, and 6.25 μM. Plates were then incubated for 48 h. After 48 h incubation, the MTT colorimetric assay was performed as described previously [ 46 ]. Briefly, MTT was dissolved in PBS (5 mg/mL), and after 48 h, media were aspirated and discarded from all wells, and then 100 µL of fresh media was added in addition to 15 µL of MTT solution.…”

Section: Methodsmentioning

confidence: 99%

In Vitro Evaluation of ALDH1A3-Affinic Compounds on Breast and Prostate Cancer Cell Lines as Single Treatments and in Combination with Doxorubicin

Abusara

Ibrahim

Issa³

et al. 2023

CIMB

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Aldehyde dehydrogenase (ALDH) enzymes are involved in the growth and development of several tissues, including cancer cells. It has been reported that targeting the ALDH family, including the ALDH1A subfamily, enhances cancer treatment outcomes. Therefore, we aimed to investigate the cytotoxicity of ALDH1A3-affinic compounds that have been recently discovered by our group, on breast (MCF7 and MDA-MB-231) and prostate (PC-3) cancer cell lines. These compounds were investigated on the selected cell lines as single treatments and in combination with doxorubicin (DOX). Results showed that the combination treatment experiments of the selective ALDH1A3 inhibitors (compounds 15 and 16) at variable concentrations with DOX resulted in significant increases in the cytotoxic effect on the MCF7 cell line for compound 15, and to a lesser extent for compound 16 on the PC-3 cell line, compared to DOX alone. The activity of compounds 15 and 16 as single treatments on all cell lines was found to be non-cytotoxic. Therefore, our findings showed that the investigated compounds have a promising potential to target cancer cells, possibly via an ALDH-related pathway, and sensitize them to DOX treatment.

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Chemical Evaluation, In Vitro and In Vivo Anticancer Activity of Lavandula angustifolia Grown in Jordan

Cited by 8 publications

References 28 publications

Anti-inflammatory and antioxidant efficacy of lavender oil in experimentally induced thrombosis

Anti-inflammatory and antioxidant efficacy of lavender oil in experimentally induced thrombosis

Chemical Composition, Antioxidant, and Antibacterial Activity of Ruta chalepensis L. Ethanolic Extract

In Vitro Evaluation of ALDH1A3-Affinic Compounds on Breast and Prostate Cancer Cell Lines as Single Treatments and in Combination with Doxorubicin

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