Anti-inflammatory and antioxidant efficacy of lavender oil in experimentally induced thrombosis

Abstract

Background Lavender oil (LO) possesses anti-inflammatory, antioxidant, antifungal, antibacterial, sedative, cardio-protective, and antinociceptive properties. Thrombosis and inflammation are interplayed processes that interact and influence one another. Our research compared three routes of administration to assess the efficacy of pretreatment with LO on carrageenan-induced thrombosis in rat tail. Materials and methods Wistar-Bratislava white rats were randomly divided into five groups of ten rats each and pretreated 3 consecutive days prior the inducement of thrombosis to with one dose of LO (150 mg/kg body weight (b.w.)): per os by gavage (TLOPO group), intraperitoneal (TIPLO group) and subcutaneous (TSCLO group). We also have a control (C, received saline solution 0.9% and DMSO (vehicle) 1 ml intraperitoneal (i.p.)) group and a group with thrombosis (T group, received saline solution 0.9% plus vehicle 1 ml i.p.). Histopathological examinations were conducted together with measurements of the circulating levels of three oxidative stress markers, antioxidant effect (TAC and THIOL), and three proinflammatory cytokines (TNF- α, RANTES, and MCP-1). Results When administered intraperitoneally, lavender oil has the best efficacy on circulating levels of oxidative stress parameters (MDA, NOx, TOS), one oxidative stress marker (THIOL), and all studied proinflammatory cytokines (p-values < 0.02). Moreover, TIPLO displayed the closest values for bleeding and clotting time to the C group, as well as the lowest length of the thrombus than the T, TPOLO, and TSCLO groups (p-values < 0.001). The TIPLO group has histological appearance comparable to the C group, with the exception of the presence of oedema. Conclusions Lavender oil pretreatment with intraperitoneal administration as three days, one-dose per day, showed anti-inflammatory and antioxidant efficacy in experimentally induced thrombosis.

Adjuvant Effects of Lavandula angustifolia Oil in Experimental Carrageenan-Induced Thrombosis

“…The results observed in our study on the evaluated biomarkers align with the results of histopathological analysis (Figure 6) and demonstrate the anti-thrombotic properties of LO. Our results are consistent with previous in vitro and in vivo studies documenting the anti-thrombotic and antiplatelet properties of LO's main compounds (linalool and linalyl acetate) [23,43].…”

“…Other active compounds are 1,8-cineol, lavandulol, lavandulyl acetate, camphor, cis-β-ocimene, trans-β-ocimene, 1-terpinen-4-ol, α-terpineol, limonene, tannins, coumarins, flavonoids, phytosterols, and triterpenes [22]. We reported the effect of Lavandula angustifolia oil on shortening the length of thrombosis and reducing microscopic tissue damage in an experimental model of thrombosis, with better results obtained when administrated intraperitoneally [23]. Our current study aimed to evaluate the anti-inflammatory and antioxidant effects of Lavandula angustifolia oil in addition to nadroparin calcium (Fraxiparine) in carrageenan-induced thrombosis.…”

Antibacterial Activity Assessment of Chitosan/Alginate Lavender Essential Oil Membranes for Biomedical Applications

“…Currently, it is present in cosmetics, perfumes, and, particularly, in nutraceuticals and pharmaceuticals [ 11 ]. This is due to LEO therapeutic attributes, such as its anti-inflammatory and antioxidant properties and its beneficial effects on diseases related to the nervous system [ 12 , 13 ]. It also plays an important role in products related to the treatment of stress or anxiety or in aromatherapy to alleviate various pathologies [ 14 , 15 ].…”