Chemical, Electrical and Tactile Sensitivity Changes After Middle Ear Surgery

Pellegrino, Robert; Hummel, Thomas

doi:10.1177/0003489419901136

Cited by 7 publications

(3 citation statements)

References 32 publications

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“…As expected, patients showed significantly reduced taste sensitivity in taste strips and electrogustometry testing, with threshold in patients being twice as high as in controls for all four regions of the tongue. Our results confirmed the strength of the electrogustometry analysis in detecting gustatory impairments 40 , 41 . In contrast, the whole mouth testing using supra-threshold taste sprays did not show any differences between the two groups.…”

Section: Discussionsupporting

confidence: 86%

Time–frequency analysis of gustatory event related potentials (gERP) in taste disorders

Mastinu,

Grzeschuchna,

Mignot

et al. 2024

Sci Rep

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In taste disorders, the key to a correct diagnosis and an adequate treatment is an objective assessment. Compared to psychophysical tests, EEG-derived gustatory event-related potentials (gERP) could be used as a less biased measure. However, the responses identified using conventional time-domain averaging show a low signal-to-noise ratio. This study included 44 patients with dysgeusia and 59 healthy participants, who underwent a comprehensive clinical examination of gustatory function. gERPs were recorded in response to stimulation with two concentrations of salty solutions, which were applied with a high precision gustometer. Group differences were examined using gERP analyzed in the canonical time domain and with Time–Frequency Analyses (TFA). Dysgeusic patients showed significantly lower scores for gustatory chemical and electrical stimuli. gERPs failed to show significant differences in amplitudes or latencies between groups. However, TFA showed that gustatory activations were characterized by a stronger power in controls than in patients in the low frequencies (0.1–4 Hz), and a higher desynchronization in the alpha-band (8–12 Hz). Hence, gERPs reflect the altered taste sensation in patients with dysgeusia. TFA appears to enhance the signal-to-noise ratio commonly present when using conventional time-domain averaging, and might be of assistance for the diagnosis of dysgeusia.

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Section: Discussionsupporting

confidence: 86%

Time–frequency analysis of gustatory event related potentials (gERP) in taste disorders

Mastinu,

Grzeschuchna,

Mignot

et al. 2024

Sci Rep

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“…One study reported that EGM was better at detecting age-related decline in taste than taste strip test 28 . Another study found that EGM were more sensitive to deviations of taste and showed no signs of recovery in patients with taste impairment after middle ear surgery unlike taste strip test 29 . In the MDS analysis in this study, chemical taste test and EGM constituted a well-distinguished area.…”

Section: Discussionmentioning

confidence: 97%

Visualization of the relationship between electrogustometry and whole mouth test using multidimensional scaling

Kim

Cho

et al. 2023

Sci Rep

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Interpreting the relationship between different taste function tests of different stimuli, such as chemical and electrical stimulation, is still poorly understood. This study aims to analyze visually as well as quantitatively how to interpret the relationship of results between taste function tests using different stimuli. Patients who underwent the whole mouth test and Electrogustometry (EGM) at a tertiary medical center between August 2018 and December 2018 were reviewed retrospectively with electronic medical records. Of the 110 patients, a total of 86 adults who self-reported that their taste function was normal through a questionnaire were enrolled. EGM measured the thresholds of the chorda tympani (CT) and glossopharyngeal nerve (GL) area of the tongue. The whole mouth test measured detection and recognition thresholds for sweet, salty, bitter, sour, and umami taste. Statistical analyses of Pearson’s, Spearman’s rank and polyserial correlation and multidimensional scaling (MDS) was performed. The EGM threshold for the average value of both CT regions and the recognition threshold of the whole mouth test were significantly correlated in sweet, salty, bitter, and sour taste (r = 0.244–0.398, P < 0.05), and the detection threshold was correlated only significant in sweet (r = 0.360, P = 0.007). In the MDS analysis results, the three-dimensional (D) solution was chosen over the 2-D solution because of the lower stress. Detection-, recognition threshold of whole mouth test and EGM thresholds of CT and GL area, those were standardized by Z-score, formed well-distinguished sections in the MDS analyses. The EGM threshold of the CT area was closer to the detection and recognition thresholds than the EGM threshold of the GL area. In general, the EGM threshold was closer to the recognition threshold than the detection threshold for each taste. Overall, visualization of the relationship of whole mouth test and EGM by MDS was in good agreement with quantitative analysis. EGM and whole mouth test seem to reflect different aspects of taste. However, when interpreting the EGM results, the EGM threshold of the CT area will show more similarity to the recognition threshold than the detection threshold for the whole mouth test.

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“…To date, there is no consensus regarding which type of CTN injury, obtained during primary stapes surgery or cochlear implantation, leads to the least burden. Change in taste sensation can alter the enjoyment of food, which is a burden to the patient [2,3]. Some articles concluded that the taste outcome is better if the CTN is sacrificed instead of being preserved but damaged by stretching [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

The impact of injury of the chorda tympani nerve during primary stapes surgery or cochlear implantation on taste function, quality of life and food preferences: A study protocol for a double-blind prospective prognostic association study

et al. 2023

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Background The chorda tympani nerve (CTN) is a mixed nerve, which carries sensory and parasympathetic fibres. The sensory component supplies the taste sensation of the anterior two-thirds of the ipsilateral side of the tongue. During middle ear surgery the CTN is exposed and frequently stretched or sacrificed, because it lacks a bony covering as it passes through the middle ear. Injury may cause hypogeusia, ageusia or altered taste sensation of the ipsilateral side of the tongue. To date, there is no consensus regarding which type of CTN injury (sacrificing or stretching), during middle ear surgery, leads to the least burden for the patient. Methods A double-blind prospective prognostic association study was designed in a single medical centre in the Netherlands to determine the effect of CTN injury on postoperative taste disturbance and quality of life. 154 patients, who will undergo primary stapes surgery or cochlear implantation will be included. The taste sensation, food preferences and quality of life of these patients will be evaluated preoperatively and at one week, six weeks and six months postoperatively using the Taste Strip Test, Electrogustometry, supplementary questionnaire on taste disturbance, Macronutrient and Taste Preference Ranking Task, Appetite, Hunger and Sensory Perception questionnaire and Questionnaire of Olfactory Disorders to assess the association of these outcomes with CTN injury. Evaluation of olfactory function will only take place preoperatively and at one week postoperatively using the Sniffin’ Sticks. The patient and outcome assessor are blinded to the presence or absence of CTN injury. Discussion This study is the first to validate and quantify the effect of chorda tympani nerve injury on taste function. The findings of this study may lead to evidence-based proof of the effect of chorda tympani injury on taste function with consequences for surgical strategies. Trial registration Netherlands Trial Register NL9791. Registered on 10 October 2021.

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Chemical, Electrical and Tactile Sensitivity Changes After Middle Ear Surgery

Cited by 7 publications

References 32 publications

Time–frequency analysis of gustatory event related potentials (gERP) in taste disorders

Time–frequency analysis of gustatory event related potentials (gERP) in taste disorders

Visualization of the relationship between electrogustometry and whole mouth test using multidimensional scaling

The impact of injury of the chorda tympani nerve during primary stapes surgery or cochlear implantation on taste function, quality of life and food preferences: A study protocol for a double-blind prospective prognostic association study

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