Chemical Diversity of Secondary Metabolites Produced by Brazilian Endophytic Fungi

Ribeiro, Bruno de Almeida; Mata, Thiara B da; Canuto, Gisele André Baptista; Silva, Eliane de Oliveira

doi:10.1007/s00284-020-02264-0

Cited by 10 publications

(10 citation statements)

References 91 publications

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“…Endophytic fungi are microorganisms that live in healthy plant tissues and do not cause any loss or disease to the host plant (Ribeiro et al, 2021). Endophytic fungi are an important resource of natural bioactive compounds (Li et al, 2008;Liu et al, 2014;Chen et al, 2016;Nalin Rathnayake et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Paecilins F–P, new dimeric chromanones isolated from the endophytic fungus Xylaria curta E10, and structural revision of paecilin A

Wei

Shi

et al. 2022

Front. Microbiol.

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A total of eleven new dimeric chromanones, paecilins F-P (2–12), were isolated from the endophytic fungus Xylaria curta E10, along with four known analogs (1, 13–15). Their structures and absolute configurations were determined by extensive experimental spectroscopic methods, single-crystal X-ray diffraction, and equivalent circulating density (ECD) calculations. In addition, the structure of paecilin A, which was reported to be a symmetric C8-C8′ dimeric pattern, was revised by analysis of the nuclear magnetic resonance (NMR) data, and single-crystal X-ray diffraction. Compound 1 showed antifungal activity against the human pathogenic fungus Candida albicans with a minimum inhibitory concentration of 16 μg/mL, and Compounds 8 and 10 showed antibacterial activity against the gram-negative bacterium Escherichia coli with the same minimum inhibitory concentration of 16 μg/mL.

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Section: Introductionmentioning

confidence: 99%

Paecilins F–P, new dimeric chromanones isolated from the endophytic fungus Xylaria curta E10, and structural revision of paecilin A

Wei

Shi

et al. 2022

Front. Microbiol.

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“…The current investigations focus on the silent gene clusters of pathogens, alongside their activation and function after plant infection [ 254 ]. For instance, Motoyama [ 255 ] investigated the rice-blast fungus, Pyricularia oryzae , and identified secondary metabolites such as melanin, a polyketide compound required for rice infection, pyriculols, phytotoxic polyketide compounds, nectriapyrones, antibacterial polyketide compounds, produced mainly by symbiotic fungi including endophytes and plant pathogens, and tenuazonic acid, a well-known mycotoxin produced by various plant pathogenic fungi. Several reviews also discuss the beneficial microbes.…”

Section: Introductionmentioning

confidence: 99%

Is Endophytic Colonization of Host Plants a Method of Alleviating Drought Stress? Conceptualizing the Hidden World of Endophytes

Byregowda

Prasad

Oelmüller

et al. 2022

IJMS

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In the wake of changing climatic conditions, plants are frequently exposed to a wide range of biotic and abiotic stresses at various stages of their development, all of which negatively affect their growth, development, and productivity. Drought is one of the most devastating abiotic stresses for most cultivated crops, particularly in arid and semiarid environments. Conventional breeding and biotechnological approaches are used to generate drought-tolerant crop plants. However, these techniques are costly and time-consuming. Plant-colonizing microbes, notably, endophytic fungi, have received increasing attention in recent years since they can boost plant growth and yield and can strengthen plant responses to abiotic stress. In this review, we describe these microorganisms and their relationship with host plants, summarize the current knowledge on how they “reprogram” the plants to promote their growth, productivity, and drought tolerance, and explain why they are promising agents in modern agriculture.

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“…Endophytic fungi are present in all plants and, together with host plants, determine the production of secondary metabolites (Waqas et al, 2012 ; Adeleke and Babalola, 2021 ). With the development of next-generation sequencing, there is increasing evidence that the compositional pattern of endophytic fungi is related to the production of specific secondary metabolites (Lunardelli Negreiros de Carvalho et al, 2016 ; Dang et al, 2021 ; Ribeiro et al, 2021 ). In some crops and medicinal plants, it is also recognized that the specific community composition pattern can reflect the quality and yield of the host plant (Song et al, 2010 ; Vergara et al, 2018 ; Cao et al, 2021 ; Martins et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Colonization characteristics of fungi in Polygonum hydropipe L. and Polygonum lapathifolium L. and its effect on the content of active ingredients

Zhang

Lv²,

Tian³

et al. 2022

Front. Plant Sci.

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Polygonum hydropiper, is a plant of the Persicaria genus, which is commonly used to treat various diseases, including gastrointestinal disorders, neurological disorders, inflammation, and diarrhea. However, because of different local standards of P. hydropiper, people often confuse it with Polygonum lapathifolium L. and other closely related plants. This poses a serious threat to the safety and efficacy of the clinical use of P. hydropiper. This study aims to determine the six active ingredients of P. hydropiper and P. lapathifolium. Then the endophytic fungi and rhizosphere soil of the two species were sequenced by Illumina Miseq PE300. The results show significant differences between the community composition of the leaves, stems, and roots of the P. hydropiper and the P. lapathifolium in the same soil environment. Of the six secondary metabolites detected, five had significant differences between P. hydropiper and P. lapathifolium. Then, we evaluated the composition of the significantly different communities between P. hydropiper and P. lapathifolium. In the P. hydropiper, the relative abundance of differential communities in the leaves was highest, of which Cercospora dominated the differential communities in the leaves and stem; in the P. lapathifolium, the relative abundance of differential community in the stem was highest, and Cladosporium dominated the differential communities in the three compartments. By constructing the interaction network of P. hydropiper and P. lapathifolium and analyzing the network nodes, we found that the core community in P. hydropiper accounted for 87.59% of the total community, dominated by Cercospora; the core community of P. lapathifolium accounted for 19.81% of the total community, dominated by Sarocladium. Of these core communities, 23 were significantly associated with active ingredient content. Therefore, we believe that the community from Cercospora significantly interferes with recruiting fungal communities in P. hydropiper and affects the accumulation of secondary metabolites in the host plant. These results provide an essential foundation for the large-scale production of P. hydropiper. They indicate that by colonizing specific fungal communities, secondary metabolic characteristics of host plants can be helped to be shaped, which is an essential means for developing new medicinal plants.

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Chemical Diversity of Secondary Metabolites Produced by Brazilian Endophytic Fungi

Cited by 10 publications

References 91 publications

Paecilins F–P, new dimeric chromanones isolated from the endophytic fungus Xylaria curta E10, and structural revision of paecilin A

Paecilins F–P, new dimeric chromanones isolated from the endophytic fungus Xylaria curta E10, and structural revision of paecilin A

Is Endophytic Colonization of Host Plants a Method of Alleviating Drought Stress? Conceptualizing the Hidden World of Endophytes

Colonization characteristics of fungi in Polygonum hydropipe L. and Polygonum lapathifolium L. and its effect on the content of active ingredients

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