2018
DOI: 10.1002/anie.201805620
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Chemical Design of Non‐Ionic Polymer Brushes as Biointerfaces: Poly(2‐oxazine)s Outperform Both Poly(2‐oxazoline)s and PEG

Abstract: The era of poly(ethylene glycol) (PEG) brushes as a universal panacea for preventing non-specific protein adsorption and providing lubrication to surfaces is coming to an end. In the functionalization of medical devices and implants, in addition to preventing non-specific protein adsorption and cell adhesion, polymer-brush formulations are often required to generate highly lubricious films. Poly(2-alkyl-2-oxazoline) (PAOXA) brushes meet these requirements, and depending on their side-group composition, they ca… Show more

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Cited by 119 publications
(142 citation statements)
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“…In spite of higher Σ values, that is, a stronger overlap for PMOXA brushes in comparison to PEG brushes [Figure (b)], PMOXA chains showed higher n(H 2 O/monomer) values in comparison to PEG chains at their corresponding highest n monomer . In agreement with literature, this observation indicates a higher hydrophilicity for PMOXA, in which PMOXA chains carry more associated H 2 O molecules in comparison to PEG. The chemical structure of PMOXA (Figure ) that contains NCO repeating units leads to higher electronegativity and thus higher affinity towards H 2 O molecules.…”
Section: Resultssupporting
confidence: 92%
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“…In spite of higher Σ values, that is, a stronger overlap for PMOXA brushes in comparison to PEG brushes [Figure (b)], PMOXA chains showed higher n(H 2 O/monomer) values in comparison to PEG chains at their corresponding highest n monomer . In agreement with literature, this observation indicates a higher hydrophilicity for PMOXA, in which PMOXA chains carry more associated H 2 O molecules in comparison to PEG. The chemical structure of PMOXA (Figure ) that contains NCO repeating units leads to higher electronegativity and thus higher affinity towards H 2 O molecules.…”
Section: Resultssupporting
confidence: 92%
“…Recently, both linear and cyclic variants of poly(2‐oxazoline) were studied by Morgese et al . which also showed long‐term stability for poly(2‐oxazoline)s, both in terms of biopassivity to nonspecific adsorption and lubrication properties . On the contrary, Ulbricht et al .…”
Section: Introductionmentioning
confidence: 97%
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“…[5] POX has been studied as as ubstitution for polyethylene glycol in biomedical applications for antifouling,d rug and protein conjugation, and fabricating drug carriers for long circulation time. [6] Surprisingly,POX itself is less studied as an antimicrobial agent although it has been used as either the hydrophilic backbone or satellite group within antimicrobial polymers to balance toxicity of quaternary amines that exert antibacterial properties. [7] In this study,w ed esigned peptide mimetics using POX through the carbonyl translocation strategy (Figure 1a).…”
Section: Introductionmentioning
confidence: 99%
“…A general comparison between the biopassive and nanotribological properties of PEG, different PAOXAs and poly(2-methyl-2-oxazine) (PMOZI) brushes highlights the chemical design parameters necessary for fabricating low-fouling and highly lubricating surfaces. [63] Also in this study, compositionally different brushes were assembled on metal oxide surfaces from PLL-g-X graft-copolymers, with X=PEG, poly(2-methyl-2-oxazoline) (PMOXA), PEOXA, and PMOZI (Figure 5,a). The biopassive properties of the different brushes were tested by incubating them both with FHS and bovine chondrocytes, and appeared to be strongly correlated to the hydration and chain flexibility characteristic of each brush type.…”
Section: Alternatives To Peg Brushesmentioning
confidence: 99%