Chemical design of nanozymes for biomedical applications

Wei, Min; Lee, Ji-Young; Xia, Fan; Lin, Peihua; Hu, Xi; Li, Fangyuan; Ling, Daishun

doi:10.1016/j.actbio.2021.02.036

Cited by 83 publications

(63 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Different nanomaterials mimic the activity of different enzymes. The mimic activity can be affected by the structure of nanozymes, including the particle size [ 99 ], surface modification [ 100 , 101 ], and morphology [ 102 ] to improve the catalytic activity, substrate specificity, and stability [ 103 , 104 ]. Many nanozymes are size-dependent since smaller nanozymes show a higher surface-to-volume ratio, which enhances the interactions with substrates because of the more active sites exposed [ 99 ].…”

Section: Nanozyme Classification and Their Catalytic Mechanismsmentioning

confidence: 99%

Nanozymes—Hitting the Biosensing “Target”

Darland

Zhao

2021

Sensors

View full text Add to dashboard Cite

Nanozymes are a class of artificial enzymes that have dimensions in the nanometer range and can be composed of simple metal and metal oxide nanoparticles, metal nanoclusters, dots (both quantum and carbon), nanotubes, nanowires, or multiple metal-organic frameworks (MOFs). They exhibit excellent catalytic activities with low cost, high operational robustness, and a stable shelf-life. More importantly, they are amenable to modifications that can change their surface structures and increase the range of their applications. There are three main classes of nanozymes including the peroxidase-like, the oxidase-like, and the antioxidant nanozymes. Each of these classes catalyzes a specific group of reactions. With the development of nanoscience and nanotechnology, the variety of applications for nanozymes in diverse fields has expanded dramatically, with the most popular applications in biosensing. Nanozyme-based novel biosensors have been designed to detect ions, small molecules, nucleic acids, proteins, and cancer cells. The current review focuses on the catalytic mechanism of nanozymes, their application in biosensing, and the identification of future directions for the field.

show abstract

Section: Nanozyme Classification and Their Catalytic Mechanismsmentioning

confidence: 99%

Nanozymes—Hitting the Biosensing “Target”

Darland

Zhao

2021

Sensors

View full text Add to dashboard Cite

show abstract

“…Up to date, more than 300 nanomaterials are described with enzyme-mimicking activity [ 147 ]. Currently, nanozyme has demonstrated to mimic activities of enzymes belonging to the oxidoreductase family (i.e., catalase and peroxidase) and therefore can also be applied for cancer theranostics [ 145 , 148 ]. The developed nanoparticle-based sensor platform successfully identified circulating tumor cells in melanoma by catalyzing the oxidation of TMB (3,3',5,5'-tetramethylbenzidine) into a blue-colored product [ 25 ].…”

Section: Nanoparticles In Melanoma Theranosticsmentioning

confidence: 99%

Magnetic nanoparticles in theranostics of malignant melanoma

et al. 2021

View full text Add to dashboard Cite

Malignant melanoma is an aggressive tumor with a tendency to metastasize early and with an increasing incidence worldwide. Although in early stage, melanoma is well treatable by excision, the chances of cure and thus the survival rate decrease dramatically after metastatic spread. Conventional treatment options for advanced disease include surgical resection of metastases, chemotherapy, radiation, targeted therapy and immunotherapy. Today, targeted kinase inhibitors and immune checkpoint blockers have for the most part replaced less effective chemotherapies. Magnetic nanoparticles as novel agents for theranostic purposes have great potential in the treatment of metastatic melanoma. In the present review, we provide a brief overview of treatment options for malignant melanoma with different magnetic nanocarriers for theranostics. We also discuss current efforts of designing magnetic particles for combined, multimodal therapies (e.g., chemotherapy, immunotherapy) for malignant melanoma.

show abstract

“…In the past decade, significant progress has been made in synthesis of oxidoreductase family nanozymes: peroxidase (POD), oxidase (OXD), catalase (CAT), superoxide dismutase (SOD), hydrolase family, and recently lyase family and isomerase family, and in understanding their catalytic mechanisms, which have advanced nanozymes beyond simple replacement of natural enzymes. [ 9 ] This has tremendously broadened the applications, including biosensing and disease treatment. [ 10 ] Notably, during the current COVID‐19 pandemic, the exploration of nanozymes as powerful toolkits in diagnostic viral testing and antiviral therapy has attracted growing attention.…”

Section: Introductionmentioning

confidence: 99%

Exploration of nanozymes in viral diagnosis and therapy

et al. 2022

Self Cite

View full text Add to dashboard Cite

Nanozymes are nanomaterials with similar catalytic activities to natural enzymes. Compared with natural enzymes, they have numerous advantages, including higher physiochemical stability, versatility, and suitability for mass production. In the past decade, the synthesis of nanozymes and their catalytic mechanisms have advanced beyond the simple replacement of natural enzymes, allowing for fascinating applications in various fields such as biosensing and disease treatment. In particular, the exploration of nanozymes as powerful toolkits in diagnostic viral testing and antiviral therapy has attracted growing attention. It can address the great challenges faced by current natural enzyme‐based viral testing technologies, such as high cost and storage difficulties. Therefore, nanozyme can provide a novel nanozyme‐based antiviral therapeutic regime with broader availability and generalizability that are keys to fighting a pandemic such as COVID‐19. Herein, we provide a timely review of the state‐of‐the‐art nanozymes regarding their catalytic activities, as well as a focused discussion on recent research into the use of nanozymes in viral testing and therapy. The remaining challenges and future perspectives will also be outlined. Ultimately, this review will inform readers of the current knowledge of nanozymes and inspire more innovative studies to push forward the frontier of this field.

show abstract

Chemical design of nanozymes for biomedical applications

Cited by 83 publications

References 94 publications

Nanozymes—Hitting the Biosensing “Target”

Nanozymes—Hitting the Biosensing “Target”

Magnetic nanoparticles in theranostics of malignant melanoma

Exploration of nanozymes in viral diagnosis and therapy

Contact Info

Product

Resources

About