Chemical Derivatives of Gramicidin

Fraenkel-Conrat, H.; Lewis, John B.; Dimick, K. P.; Edwards, B. C.; Reitz, H. C.; Ferrel, Robert E.; B, Brandon; Olcott, Henry Steel

doi:10.3181/00379727-63-15581

Cited by 6 publications

(3 citation statements)

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“…One of the early approaches reported by Cornell et al employed gramicidin derivatives [302] for detection of molecular binding interactions of antibodies with antigens [168 •• ]. The sensor comprised a supported lipid bilayer that was tethered on a gold electrode and contained tethered gramicidin monomers in one leaflet and free monomers of gramicidin derivatives (gramicidin monomers with a biotin molecule attached) in the other leaflet (Figure 9a).…”

Section: Applications Of Biological Pores For Sensingmentioning

confidence: 99%

“…Ligand-decorated derivatives of antibiotic peptides such as gramicidin [302] and alamethicin have also provided platforms to detect [193 • ,305–309] or quantify [24] interactions between proteins and ligands. Antonenko and coworkers have explored the application of biotinylated gramicidin peptides for studying interactions between avidin or streptavidin with biotin.…”

Section: Applications Of Biological Pores For Sensingmentioning

confidence: 99%

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Applications of biological pores in nanomedicine, sensing, and nanoelectronics

Majd

Yusko

Billeh

et al. 2010

Current Opinion in Biotechnology

307

319

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Biological protein pores and pore-forming peptides can generate a pathway for the flux of ions and other charged or polar molecules across cellular membranes. In nature, these nanopores have diverse and essential functions that range from maintaining cell homeostasis and participating in cell signaling to activating or killing cells. The combination of the nanoscale dimensions and sophisticated – often regulated – functionality of these biological pores make them particularly attractive for the growing field of nanobiotechnology. Applications range from single-molecule sensing to drug delivery and targeted killing of malignant cells. Potential future applications may include the use of nanopores for single strand DNA sequencing and for generating bio-inspired, and possibly, biocompatible visual detection systems and batteries. This article reviews the current state of applications of pore-forming peptides and proteins in nanomedicine, sensing, and nanoelectronics.

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Section: Applications Of Biological Pores For Sensingmentioning

confidence: 99%

Section: Applications Of Biological Pores For Sensingmentioning

confidence: 99%

Applications of biological pores in nanomedicine, sensing, and nanoelectronics

Majd

Yusko

Billeh

et al. 2010

Current Opinion in Biotechnology

307

319

View full text Add to dashboard Cite

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“…oheffllcal determination (40). This haa been stated to be about five times the tryptophan content of any known pro tein (41).…”

Section: -mentioning

confidence: 98%

Synthesis of some valine derivatives as potential antibacterial agents

Minard

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