Chemical cross-linking approach for prolonging diclofenac sodium release from pectin-based delivery system

Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels

“…Generally, bio-based hydrogels can be prepared using several chemical and ionic crosslinking methods and also in different ways, e.g., photopolymerization and exposure to radiation (e.g., gamma rays or microwaves) [29]. The chemical method is based on the formation of covalent bridges during the reaction between the polymer or monomer with the crosslinking agent (N, N'-methylenebisacrylamine (NMBA) and poly(ethylene glycol) diacrylate (PEGDA) in the presence of an initiator (ammonium, potassium or sodium persulfates [30][31][32]. Meanwhile, the method of crosslinking by ionic interaction takes place in the presence of bivalent or multivalent ions, such as Ca 2+ , Cu 2+ , Fe 2+ or Al 3+ .…”

Nanoscale strides: exploring innovative therapies for breast cancer treatment

“…Functionalized liposomes may carry the medication to a particular location, such as a cell organelle, because of specific receptor-selective associations with various forms of targeting ligands, such as peptides and antibodies. 99 Hypoxia-responsive liposomes are primed by the injection of nitroimidazole derivative into the liposomal membrane. These patients exhibited a decrease in the hypoxic metabolism of the tumor and stimulated drug delivery due to liposomal degeneration.…”

Pectin hydrogels for controlled drug release: Recent developments and future prospects

“…To enhance the stability of pectin-Ca 2+ gels in oral colon-specific drug delivery, chemically cross-linked pectin carriers were crafted using succinic anhydride and glutaric dialdehyde as cross-linking agents, mitigating instability concerns in the upper gastrointestinal tract. This innovative approach ensures a reliable and controlled drug release system ( Wang et al, 2019 ).…”