Chemical Construction of Polyfunctional Nanocomposites and Nanorobots for Medico-biological Applications

Горбик, П. П.; Dubrovin, I. V.; Petranovska, А. L.; Абрамов, М. В.; Usov, Denys; Storozhuk, Liudmyla; Turanska, S. P.; Turelyk, M. P.; Чехун, В Ф; Lukyanova, Natalia; Shpak, A. P.; Korduban, A. M.

doi:10.1007/978-90-481-2309-4_6

Cited by 10 publications

(21 citation statements)

References 3 publications

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“…Biocompatibility of Fe 3 O 4 /HA NC is a known fact [3][4][5][6][7][8][9][10][11]. In this paper, biocompatibility and bioactivity of the produced samples was monitored by their effect on viability of baker's yeast S. cerevisiae cells [11].…”

Section: Biocompatibility and Bioactivity Of Nanocompositesmentioning

confidence: 99%

“…6a), the coercive force (H c ) of ML 3 is equal to (2 ± 0.5) Oe. The samples of Fe 3 O 4 NP and DR 3 of ML 3 , distributed in paraffin, are characterized by H c 89.7 Oe and 90.0 Oe, respectively (Fig. 6b).…”

Section: Study Of Magnetic and Structural Properties Of Nanocompositementioning

confidence: 99%

“…Taking into account that in conditions of magnetic saturation the Langevin function L(n) ? 1, and in DR a volumetric concentration of solid phase *1, formula (1) can be written as 3 is the volume fraction of magnetite in the sample; d = h 2 ? h 3 ?…”

Section: Study Of Magnetic and Structural Properties Of Nanocompositementioning

confidence: 99%

“…Magnetic nanoparticles are widely used for the preparation of novel multifunctional therapeutic and diagnostic agents for different fields of medicine [1][2][3], including oncology. Conjugation of nanoparticles with corresponding antibody provides nanoparticles with the ability to recognize and ''mark'' specific microbiological objects, cell populations, microorganisms, and so on.…”

Section: Introductionmentioning

confidence: 99%

“…Conjugation of nanoparticles with corresponding antibody provides nanoparticles with the ability to recognize and ''mark'' specific microbiological objects, cell populations, microorganisms, and so on. On this basis, the concept has been substantiated for chemical construction of magnetosensitive nanocomposites with multilevel hierarchical architecture, characterized with functions of ''nanoclinics'' [2] and biomedical nanorobots [3][4][5] (recognition of microbiological objects in biological environments; the aimed delivery of drugs to target cells and organs using an external magnetic field and deposition; complex chemo-, immuno-, neutron capture, real-time hyperthermic therapy and diagnostics).…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and properties of magnetite/hydroxyapatite/doxorubicin nanocomposites and magnetic liquids based on them

et al. 2016

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Core-shell magnetosensitive nanocomposites (NC) based on single-domain magnetite (Fe 3 O 4 , core), with a shell consisting of hydroxyapatite (HA) and cytotoxic drug doxorubicin (DOX) layers have been synthesized. The processes of DOX adsorption on Fe 3 O 4 /HA surface from physiologic solution have been studied. DOX release into saline was found to decrease with growing of its quantity on NC surface. It has been determined that cytotoxic influence and antiproliferative activity of Fe 3 O 4 /HA/DOX NC with respect to Saccharomyces cerevisiae cells are characteristic for interaction of these cells with a free form of doxorubicin. Magnetic liquids containing Fe 3 O 4 /HA/ DOX NC stabilized by sodium oleate and polyethylene glycol were prepared and investigated. It is shown that using the ensemble of Fe 3 O 4 carriers as a superparamagnetic probe, the Langevin's paramagnetism theory, and the values of density of nanocomposite constituents, one can evaluate the size parameters of their shell, which has been corroborated by independent measurements of specific surface area of nanostructures and kinetic stability of the corresponding magnetic liquids. The obtained results may be useful for development and optimization of novel forms of magnetocarried medical remedies of targeted delivery and adsorbents based on nanocomposites of superparamagnetic core-shell type with multilevel nanoarchitecture, as well as for determination and control of the size parameters of its components.

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Section: Biocompatibility and Bioactivity Of Nanocompositesmentioning

confidence: 99%

Section: Study Of Magnetic and Structural Properties Of Nanocompositementioning

confidence: 99%

Section: Study Of Magnetic and Structural Properties Of Nanocompositementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis and properties of magnetite/hydroxyapatite/doxorubicin nanocomposites and magnetic liquids based on them

et al. 2016

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Dextran Coatings for Aggregation Control of Layer-by-Layer Assembled Polyelectrolyte Microcapsules

Usov

Sukhorukov

2010

Langmuir

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We propose dextran and dextran polyaldehyde (DPA) coatings for modification of layer-by-layer (LbL) assembled polyelectrolyte microcapsules which provide stability against aggregation in 0.75 M aqueous solutions of mono- and bivalent ions (Na(+), Cl(-), Ca(2+), HPO(4)(2-)). The microcapsules were prepared of three bilayers of poly(4-styrenesulfonate) (PSS) and poly(allylamine) (PAH). Dextran and its derivatives were attached to amino-terminated surface of the microcapsules via three types of chemical bonds of subsequently increasing strength: (1) hydrogen bonds, (2) hydrolyzable covalent cross-links resulting from aldehydes and primary amines coupling, and (3) nonhydrolyzable covalent C-N single bonds of secondary amines. Attachment of the DPA materials via the latter two types of bonds resulted in strengthening the capsules' walls which preserved a fraction of the microcapsules from disintegration upon electrostatic swelling in 0.1 M NaOH. The non-disintegrated fraction of the DPA-coated microcapsules restored their initial size after pH was decreased back to neutral. The microcapsules coated with the original dextran immobilized via hydrogen bonds and the bare microcapsules were fully dissolved under the alkaline conditions. The preserved fraction of the microcapsules was higher for the DPA materials with higher contents of the aldehyde groups and after conversion of the hydrolyzable covalent cross-links to the nonhydrolyzable secondary amines via reduction with NaBH(4). The higher contents of the aldehyde groups and the reduction led to the lower limiting swelling degree of the DPA-coated microcapsules at alkaline pH. The proposed coatings can be used for colloid stabilization of polyelectrolyte microcapsules in aqueous medium, encapsulation of pH-insensitive macromolecules at the postpreparation stage, and pH-triggered release of encapsulated material.

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Immobilization of boronic acid derivative onto the magnetic Gd-containing composites

Pylypchuk

Kovach

Іatsyshyn

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

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Aiming to develop new magnetic materials for neutron shielding applications, B- and Gd-containing magnetic nanoparticles were synthesized. Following bottom-up synthetic approach, core-shell Fe 3 O 4/Gd 2 O 3 nanocomposite particles were synthesized at the first stage. In the next stage, magnetic core-shell particles were modified with amino groups followed by grafting onto their surface of the boronic acid derivative. Such a multifunctional material, containing both boron (B) and gadolinium (Gd) atoms is a promising candidate for developing films and membranes, strongly interacting with neutrons. Due to the presence of boronic acids and bound to the indicator (Alizarin Red S), the material can induce color changes while immersed in sugar-containing solutions. Such a feature enables a possibility to estimate the number of boron atoms left after interaction with neutrons, thus allowing to check composite neutron-capture recourse.

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Chemical Construction of Polyfunctional Nanocomposites and Nanorobots for Medico-biological Applications

Cited by 10 publications

References 3 publications

Synthesis and properties of magnetite/hydroxyapatite/doxorubicin nanocomposites and magnetic liquids based on them

Synthesis and properties of magnetite/hydroxyapatite/doxorubicin nanocomposites and magnetic liquids based on them

Dextran Coatings for Aggregation Control of Layer-by-Layer Assembled Polyelectrolyte Microcapsules

Immobilization of boronic acid derivative onto the magnetic Gd-containing composites

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