Chemical Constituents of the Whole Plants of Houttuynia cordata

Dong, Lixin; Liu, Jinping; Han, Xue; Wang, Yuefei; Wang, Chunhua; Li, Zheng; Wang, Guo‐Cai

doi:10.1007/s10600-017-1991-6

Cited by 10 publications

(4 citation statements)

References 7 publications

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“…Additionally, the 34 known compounds isolated were assigned as gnaphaliin C ( 2 ), acacetin-7 -O -[6″″- O -acetyl-β- d -glucopyranosyl(1″″→2″)-α- l -rhamnopyranosyl(1‴→6″)] - β- d -glucopyranoside ( 4 ), acacetin-7 -O -[6″″- O -acetyl-β- d -glucopyranosyl(1″″→2″)-4‴- O -acetyl-α- l -rhamnopyranosyl(1‴→6″)] - β- d -glucopyranoside ( 6 ), linarin ( 8 ), acacetin-7 -O -[4‴- O -acetyl-α- l -rhamnopyranosyl(1‴→6″)] - β- d -glucopyranoside ( 9 ), apigenin ( 10 ), apigetrin ( 11 ), diosmetin ( 12 ), 5-hydroxy-6,7-dimethoxyflavone ( 13 ), 5-hydroxy-7,8-dimethoxyflavone ( 14 ), 6-hydroxy-5,7,8-trimethoxyflavone ( 15 ), butin ( 16 ), isookanin ( 17 ), 3,2′,4′-trihydroxy-4-methoxychalcone ( 18 ), 4′- O -β- d -glucopyranosyl-3,2′-dihydroxy-4-methoxychalcone ( 19 ), okanin-4-methoxy-4′- O -β- d -glucopyranoside ( 20 ), neoisoliquiritin ( 21 ), sulfuretin ( 22 ), rosmarinic acid ( 23 ), N - trans -feruloyloctopamine ( 24 ), 3,5-di- O -caffeoylquinic acid ( 25 ), everlastoside L ( 26 ), 1-(3′,4′-dihydroxycinnamoyl)cyclopentane-2,3-diol ( 27 ), ethyl caffeate ( 28 ), ( E )- p -coumaric acid ( 29 ), caffeic acid ( 30 ), osmundacetone ( 31 ), ( Z )- p -coumaric acid ( 32 ), p -hydroxybenzaldehyde ( 33 ), p -hydroxybenzoic acid ( 34 ), 3,4-dihydroxybenzoic acid ( 35 ), vanillic acid ( 36 ), benzyl-β- d -glucopyranoside ( 37 ), and neryl-β- d -glucopyranoside ( 38 ) . Overall, 22 compounds ( 2 , 9 , 15 – 22 , 24 – 28 , 31 , and 33 – 38 ) were isolated and identified from E. ciliata for the first time.…”

Section: Results and Discussionmentioning

confidence: 99%

Chemical Constituents from the Aerial Parts of Elsholtzia ciliata and Their Protective Activities on Glutamate-Induced HT22 Cell Death

et al. 2020

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A new phenolic glucoside, (7E,9E)-3-hydroxyavenalumic acid-3-O-[6′-O-(E)-caffeoyl]-β-D-glucopyranoside (1), and three new acetylated flavone glycosides, acacetin-7 7), as well as 34 known compounds (2, 4, 6, and 8−38) were isolated from the aerial parts of Elsholtzia ciliata. The chemical structures of the new compounds were determined by spectroscopic/spectrometric data interpretation using NMR and HRESIMS. The neuroprotective effect of the isolated compounds was evaluated by a cell viability assay on HT22 murine hippocampal neuronal cells. Among them, 23 compounds, including new substances 1 and 3, exhibited neuroprotective effects against glutamate-induced HT22 cell death. In

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Section: Results and Discussionmentioning

confidence: 99%

Chemical Constituents from the Aerial Parts of Elsholtzia ciliata and Their Protective Activities on Glutamate-Induced HT22 Cell Death

et al. 2020

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“…Flavonoids are widely recognized as a molecule with good antioxidant activity and beneficial effects in the treatment of neurological disorders [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ,…”

Section: Ginkgetin For the Treatment Of Neurodegenerative Diseasesmentioning

confidence: 99%

Neuroprotective Potential of Biflavone Ginkgetin: A Review

Cankaya

Devkota

Zengin

et al. 2023

Life

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Neurological disorders are becoming more common, and there is an intense search for molecules that can help treat them. Several natural components, especially those from the flavonoid group, have shown promising results. Ginkgetin is the first known biflavonoid, a flavonoid dimer isolated from ginkgo (Ginkgo biloba L.). Later, its occurrence was discovered in more than 20 different plant species, most of which are known for their use in traditional medicine. Herein we have summarized the data on the neuroprotective potential of ginkgetin. There is evidence of protection against neuronal damage caused by ischemic strokes, neurotumors, Alzheimer’s disease (AD), and Parkinson’s disease (PD). Beneficial effects in ischemic strokes have been demonstrated in animal studies in which injection of ginkgetin before or after onset of the stoke showed protection from neuronal damage. AD protection has been the most studied to date. Possible mechanisms include inhibition of reactive oxygen species, inhibition of β-secretase, inhibition of Aβ fibril formation, amelioration of inflammation, and antimicrobial activity. Ginkgetin has also shown positive effects on the relief of PD symptoms in animal studies. Most of the available data are from in vitro or in vivo animal studies, where ginkgetin showed promising results, and further clinical studies should be conducted.

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“…H.cordata has various functions such as anti-inflammatory, antibacterial, antiviral, and immune enhancing (Hemalatha et al, 2014). It is rich in volatile oil, alkaloids, flavonoids and other bioactive substances (Li et al, 2017;Chou et al, 2009). Among the components, the volatile oil of H. cordata has the highest medicinal value.…”

Section: Introductionmentioning

confidence: 99%

2-Methyl Nonyl Ketone From Houttuynia Cordata Thunb Alleviates LPS-Induced Inflammatory Response and Oxidative Stress in Bovine Mammary Epithelial Cells

Wang

Zhu

et al. 2022

Front. Chem.

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Mastitis is one of the most common diseases in dairy cows, causing huge economic losses to the dairy industry every year. Houttuynia Cordata Thunb (H.cordata) is a traditional Chinese herbal medicine that is widely used in clinical treatment. However, the therapeutic effect of 2-methyl nonyl ketone (MNK), the main volatile oil component in the aqueous vapor extract of H. cordata, on mastitis has been less studied. The purpose of this study was to investigate the protective effect and mechanism of MNK against lipopolysaccharide (LPS)-induced mastitis in vitro. The results showed that MNK pretreatment of the bovine mammary epithelial cell line (MAC-T) enhanced cell viability and inhibited LPS-induced reactive oxygen species (ROS) production and inflammatory response. MNK reduced the production of pro-inflammatory cytokines such as interleukin (IL) and tumor necrosis factor-α (TNF-α) by repressing LPS-induced activation of Toll-like receptor 4-nuclear factor-κB (TLR4-NF-κB) signaling pathway. In addition, MNK protected cells from inflammatory responses by blocking the downstream signaling of inflammatory factors. MNK also induced Heme Oxygenase-1 (HO-1) production by Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway through AKT and extracellular signal-regulated kinase (ERK) pathways, thereby reducing LPS-induced oxidative damage for MAC-T cells. In conclusion, MNK played a protective role against LPS-induced cell injury. This provides a theoretical basis for the research and development of MNK as a novel therapeutic agent for mastitis.

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Chemical Constituents of the Whole Plants of Houttuynia cordata

Cited by 10 publications

References 7 publications

Chemical Constituents from the Aerial Parts of Elsholtzia ciliata and Their Protective Activities on Glutamate-Induced HT22 Cell Death

Chemical Constituents from the Aerial Parts of Elsholtzia ciliata and Their Protective Activities on Glutamate-Induced HT22 Cell Death

Neuroprotective Potential of Biflavone Ginkgetin: A Review

2-Methyl Nonyl Ketone From Houttuynia Cordata Thunb Alleviates LPS-Induced Inflammatory Response and Oxidative Stress in Bovine Mammary Epithelial Cells

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