Chemical Constituents of the Plants in the GenusAchillea

Tang, X.; Zhang, Man Li; Shi, Qing; Kiyota, Hiromasa

doi:10.1002/cbdv.200690119

Cited by 103 publications

(51 citation statements)

References 59 publications

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“…This confirms that A. ligustica presents several chemotypes, reflected in the strong variability in the essential oil compositions from different areas, and supports the hypothesis that the chemical compositions of Achillea species are complex and susceptible to variation [23].…”

supporting

confidence: 77%

Antimicrobial Efficacy of Achillea ligusticaAll. (Asteraceae) Essential Oils against Reference and Isolated Oral Microorganisms

Cecchini

Silvi

Cresci

et al. 2012

Chemistry & Biodiversity

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The aim of this study was to verify the effectiveness of Achillea ligustica essential oils against several oral microorganisms in comparison with a commercial essential oil-containing mouthrinse (Listerine(®)) and clove oil (containing 89% eugenol). The inhibition efficacy of A. ligustica essential oils alone and in combination with Listerine(®) was evaluated by the micro-dilution method. The most susceptible microorganisms were Bacillus cereus, Streptococcus pyogenes, and Candida albicans. The efficacy was similar to that of the clove oil. The antiseptic mouthwash Listerine(®) did not exert a strong inhibition on microbial strains tested, whereas its effectiveness increased significantly when essential oil was added. The study provides additional evidence for the in vitro inhibitory activity of A. ligustica essential oils on several pathogens, suggesting their usefulness in mouthrinse formulations as an adjunct to mechanical oral hygiene regimens. Essential oil-containing mouthrinses can be beneficial, safe components of daily oral health routines, representing an efficient and without side effect alternative to prevent and control oral infections.

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supporting

confidence: 77%

Antimicrobial Efficacy of Achillea ligusticaAll. (Asteraceae) Essential Oils against Reference and Isolated Oral Microorganisms

Cecchini

Silvi

Cresci

et al. 2012

Chemistry & Biodiversity

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“…Given the widespread nature of this genus, Achillea species are used as medicinal plants against diarrhea, flatulence, emmenagogue, wound healing purposes (Honda et al, 1996) fever, common cold and digestive complaints (Si et al, 2006;Akkol et al, 2011). The herb has a strong smell and a bitter taste, for this reason it is usually mixed with sugar when used orally.…”

Section: Introductionmentioning

confidence: 99%

Ameliorating Effect of Achillea fragrantissima Against Benzene-Induced Skin Irritation: Histological Study

Al-Shathly¹,

Alqahtani²

2017

Adv. Pharm. Ethnomed

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| Organic solvents such as car fuel, which contains benzene and other solvents were known to cause skin irritation and contact dermatitis. Although anti-inflammatory steroids topical medications were used, they may result in side effects in susceptible persons. Herbal preparation was tried in literature. In the present study, Achillea fragrantissima, a wild plant in some areas of Saudi Arabia was used to speed slow-healing wounds. Thus, the study was designed to investigate its efficacy to treat experimentally induced benzene-dermatitis in mice skin. Twenty-five adult mice were shaved and animals were divided into GI as control and GII as benzene painted. The later was further divided into four subgroups; untreated, steroidal medicinal cream treated, a group treated with olive oil extract of Achillea (dried plant soaked in olive oil) and a group treated with olive oil only. Gross and histopathological observation were used to evaluate the treatment effects. Benzene painting produced skin hardening, scaling, epidermal hyperplasia and inflammatory reaction in skin dermis. Decrease in the hypodermal adipose tissue thickness was observed, those pathological changes were much improved or even absent in treated mice. Such results are similar to that observed in the group treated by medicinal cream. Achillea plant could be a source of future effective anti-dermatitis cream medicinal formulation against benzene-induced dermatitis. Olive oil extract of Achillea will be tested and compared to olive oil alone to prove the hypothesis.

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“…[2] Phytochemical investigations of over 60 Achillea species pointed out terpenoids and flavonoids as the main constituents, whereas lignans, alkamides, coumarins, sesquiterpene-coumarin ethers, and some other compounds were sporadically identified. [3,4] Although guaianolides are the most frequently occurring sesquiterpene lactones in the genus Achillea, bis-1,2 : 3,4-epoxyguaianolides and guaianolide-1,2-epoxychlorohydrins occurred only in few species, but also in some Artemisia and Tanacetum species (all belonging to family Asteraceae). [4] Here we present a detailed structural and conformational analysis of bis-1,2 : 3,4-epoxyguaianolides 1-4 and guaianolide-1,2-epoxychlorohydrins 5-12 ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Stereochemistry and conformations of natural 1,2‐epoxy‐guaianolides based on 1D and 2D NMR data and semiempirical calculations

Trifunović¹,

Milosavljević²,

Vajs³

et al. 2008

Magnetic Reson in Chemistry

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From detailed study of 1D and 2D NMR spectra of ten natural 1,2-epoxyguaianolides (bis-1,2:3,4-epoxyguaianolides and guaianolide-1,2-epoxychlorohydrins), we identified general spectral traits helpful for stereochemical assignment of such sesquiterpene lactones. We found that the chemical shifts of certain (1)H and (13)C nuclei are consistently dependent on the configuration of 1,2-epoxy-ring which could be used as a simple rule for establishing this configuration. Then, from 1D and 2D (COSY, NOESY, HMQC, HMBC) NMR data, applying the observed rule, the structure and stereochemistry of two new, diastereomeric guaianolide-1,2-epoxychlorohydrins, isolated from Achillea serbica, are determined. The NMR data, namely, nuclear overhauser enhancement (NOE) correlations, pointed out two conformations of guaianolide's cycloheptane ring. The semiempirical calculations (AM1 and PM3 methods), performed in order to gain additional information regarding conformations, resulted in three geometries of investigated lactones. Even so, the conformations derived from the NMR data agreed well with those calculated by semiempirical methods.

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Chemical Constituents of the Plants in the GenusAchillea

Cited by 103 publications

References 59 publications

Antimicrobial Efficacy of Achillea ligusticaAll. (Asteraceae) Essential Oils against Reference and Isolated Oral Microorganisms

Antimicrobial Efficacy of Achillea ligusticaAll. (Asteraceae) Essential Oils against Reference and Isolated Oral Microorganisms

Ameliorating Effect of Achillea fragrantissima Against Benzene-Induced Skin Irritation: Histological Study

Stereochemistry and conformations of natural 1,2‐epoxy‐guaianolides based on 1D and 2D NMR data and semiempirical calculations

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