Chemical Constituents of the Leaves of Heritiera littoralis

Ge, Li; Li, Yuejuan; Yang, Kun; Pan, Zheng‐Hong

doi:10.1007/s10600-016-1747-8

Cited by 6 publications

(6 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The isolation and characterization of the chemical constituents from H. littoralis have yielded a range of classes of natural products, such as triterpenoid, flavonoid, phenylpropanoid-glycerol, etc. [ 19 , 20 , 21 , 22 , 23 ]. However, there have been few reports on the biologically active constituents of H .…”

Section: Introductionmentioning

confidence: 99%

Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand

Liang

Niu

et al. 2023

Molecules

View full text Add to dashboard Cite

Two new triterpenoid glucosides, Heritiera A (1) and Heritiera B (2), and six known triterpenoid analogs (3–8) were isolated from Heritiera littoralis Dryand. Their structures were identified by comprehensive spectroscopic analyses and comparisons with the literature. The anti-inflammatory activity of the isolates from H. littoralis was evaluated using a lipopolysaccharide (LPS) stimulated RAW 264.7 cells model. The result showed that four triterpenoids exhibited potent anti-inflammatory activity. Among these compounds, compound 2 substantially inhibits the release of nitric oxide (NO) with an IC50 value of 10.33 μM. The triterpenoids from H. littoralis could be used as potential candidates for the development of new anti-inflammatory agents.

show abstract

Section: Introductionmentioning

confidence: 99%

Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand

Liang

Niu

et al. 2023

Molecules

View full text Add to dashboard Cite

show abstract

“…Existing literature had reported that the Heritiera littoralis bark exerted its anti-inflammatory effects by reducing the release of NO, PGE2, and TNF- α , as well as by downregulating iNOS and COX-2 [ 6 ]. In addition, Heritiera littoralis leaf extracts have exhibited obvious antibacterial and anticancer activities [ 7 , 8 ]. The pharmacodynamics of the Heritiera littoralis fruit has not been clearly reported in publications, but the fruit does contain anti-inflammatory chemicals, such as flavonoids and triterpenoids [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effects of Heritiera littoralis Fruits on Dextran Sulfate Sodium- (DSS-) Induced Ulcerative Colitis in Mice by Regulating Gut Microbiota and Suppressing NF-κB Pathway

Lin

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

Aim of the Study. This study is aimed at exploring the effects and pharmacological mechanisms of the extracts from the Heritiera littoralis fruit (EFH) on dextran sulfate sodium- (DSS-) induced ulcerative colitis (UC) in mice. Materials and Methods. The chemical compositions of EFH were identified using LC-ESI-MS. The mice with 3% DSS-induced UC were administered EFH (200, 400, and 800 mg/kg), sulfasalazine (SASP, 200 mg/kg), and azathioprine (AZA, 13 mg/kg) for 10 days via daily gavage. The colonic inflammation was evaluated by the disease activity index (DAI), colonic length, histological scores, and levels of inflammatory mediators. The gut microbiota was characterized by 16S rRNA gene sequencing and analysis. Results. LC-ESI-MS analysis showed that EFH was rich in alkaloids and flavones. The results indicated that EFH significantly improved the DAI score, relieved colon shortening, and repaired pathological colonic variations in colitis. In addition, proteins in the NF-κB pathway were significantly inhibited by EFH. Furthermore, EFH recovered the diversity and balance of the gut microbiota. Conclusions. EFH has protective effects against DSS-induced colitis by keeping the balance of the gut microbiota and suppressing the NF-κB pathway.

show abstract

“…H. littoralis comes from the Sterculiaceae family similar to H. fomes and reaches a height of 25 m. It forms pneumatophore root and has dark green leaves with acute apex which are generally 10–23 cm long and 4–10 cm wide [51]. This species is broadly distributed in Asia mainly in China, Taiwan, Guangdong, Guangxi, Fujian, and Philippines [92]. In Philippines, the sap is traditionally used to counteract fish, arrowhead, and spearhead poisoning and the seed is used to treat diarrhea, dysentery, and hematuria [92].…”

Section: Resultsmentioning

confidence: 99%

“…This species is broadly distributed in Asia mainly in China, Taiwan, Guangdong, Guangxi, Fujian, and Philippines [92]. In Philippines, the sap is traditionally used to counteract fish, arrowhead, and spearhead poisoning and the seed is used to treat diarrhea, dysentery, and hematuria [92]. Wang et al [126] studied the antioxidant activities on the leaves and roots using three different assays, namely DPPH, HOm and SO.…”

Section: Resultsmentioning

confidence: 99%

“…The IC 50 value for the leaf extracts for all the three methods are 0.028, 0.600, and 0.606 mg/mL, respectively. Ge et al [92] also conducted phytochemical screening and isolated four compounds namely 3,5,7-trihydroxychromone-3- O -α- l -rhamnopyranoside ( 245 ), quercetin-3- O -α- l -rhamnopyranoside ( 246 ), (2 R ,3 R )-dihydroquercetin-3- O -α- l -rhamnopyranoside ( 247 ), and kaempferol-3- O -α- l -rhamnopyranoside ( 248 ) from the ethanolic leaf extract and Revathi et al [88] reported the presence of alkaloids, tannins, polyphenols, and saponins in the stem, bark, fruit, and leaf extract.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Ethnopharmacology, Phytochemistry, and Global Distribution of Mangroves―A Comprehensive Review

et al. 2019

View full text Add to dashboard Cite

Mangroves are ecologically important plants in marine habitats that occupy the coastlines of many countries. In addition to their key ecological importance, various parts of mangroves are widely used in folklore medicine and claimed to effectively manage a panoply of human pathologies. To date, no comprehensive attempt has been made to compile and critically analyze the published literature in light of its ethnopharmacological uses. This review aims to provide a comprehensive account of the morphological characteristics, ethnobotany, global distribution, taxonomy, ethnopharmacology, phytochemical profiles, and pharmacological activities of traditionally used mangroves. Out of 84 mangrove species, only 27 species were found to be traditionally used, however not all of them are pharmacologically validated. The most common pharmacological activities reported were antioxidant, antimicrobial, and antidiabetic properties. Mangroves traditionally reported against ulcers have not been extensively validated for possible pharmacological properties. Terpenoids, tannins, steroids, alkaloids, flavonoids, and saponins were the main classes of phytochemicals isolated from mangroves. Given that mangroves have huge potential for a wide array of medicinal products and drug discovery to prevent and treat many diseases, there is a dire need for careful investigations substantiated with accurate scientific and clinical evidence to ensure safety and efficient use of these plants and validate their pharmacological properties and toxicity.

show abstract

Chemical Constituents of the Leaves of Heritiera littoralis

Cited by 6 publications

References 6 publications

Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand

Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand

Anti-Inflammatory Effects of Heritiera littoralis Fruits on Dextran Sulfate Sodium- (DSS-) Induced Ulcerative Colitis in Mice by Regulating Gut Microbiota and Suppressing NF-κB Pathway

Ethnopharmacology, Phytochemistry, and Global Distribution of Mangroves―A Comprehensive Review

Contact Info

Product

Resources

About