Chemical Constituents of <i>Cordyceps cicadae</i>

Chu, Zhi-Bo; Chang, Jun; Zhu, Ying

doi:10.1177/1934578x1501001233

Cited by 9 publications

(9 citation statements)

References 12 publications

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“…In contrast to other Cordyceps fungi, the caterpillar fungus O. sinensis has a highly repetitive genome with a limited number of genes and BGCs ( Figure 3 A) [ 24 ]. Besides the reported bioactive constituents like nucleosides, sterols and polysaccharides [ 18 , 67 , 68 , 69 ], a few compounds have been identified from this fungus with different activities such as the aurantiamides cordyceamides A and B with unclear activity/toxicity [ 70 ], the cyclodipeptide cordycedipeptide A with cytotoxicity [ 71 ], and the cyclodipeptide cordysinins with antioxidant activity [ 69 , 72 ]. Overall, the reputed health benefits of this fungus are still unclear [ 73 ].…”

Section: Unknown Mycotoxins May Be Produced By Cordycepsmentioning

confidence: 99%

Bioactive Metabolites and Potential Mycotoxins Produced by Cordyceps Fungi: A Review of Safety

Chen

Sun

Luo

et al. 2020

Toxins

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Ascomycete Cordyceps fungi such as C. militaris, C. cicadae, and C. guangdongensis have been mass produced on artificial media either as food supplements or health additives while the byproducts of culture substrates are largely used as animal feed. The safety concerns associated with the daily consumption of Cordyceps fungi or related products are still being debated. On the one hand, the known compounds from these fungi such as adenosine analogs cordycepin and pentostatin have demonstrated different beneficial or pharmaceutical activities but also dose-dependent cytotoxicities, neurological toxicities and or toxicological effects in humans and animals. On the other hand, the possibility of mycotoxin production by Cordyceps fungi has not been completely ruled out. In contrast to a few metabolites identified, an array of biosynthetic gene clusters (BGCs) are encoded in each genome of these fungi with the potential to produce a plethora of as yet unknown secondary metabolites. Conservation analysis of BGCs suggests that mycotoxin analogs of PR-toxin and trichothecenes might be produced by Cordyceps fungi. Future elucidation of the compounds produced by these functionally unknown BGCs, and in-depth assessments of metabolite bioactivity and chemical safety, will not only facilitate the safe use of Cordyceps fungi as human food or alternative medicine, but will also benefit the use of mass production byproducts as animal feed. To corroborate the long record of use as a traditional medicine, future efforts will also benefit the exploration of Cordyceps fungi for pharmaceutical purposes.

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Section: Unknown Mycotoxins May Be Produced By Cordycepsmentioning

confidence: 99%

Bioactive Metabolites and Potential Mycotoxins Produced by Cordyceps Fungi: A Review of Safety

Chen

Sun

Luo

et al. 2020

Toxins

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“…Cordyceps cicadae, a Chinese traditional food fungus, has antioxidation, anti-inflammation [1], blood sugar regulation (Li et al, 2018), renal function improvement [2,3], liver protection [4], and neuroprotection [5] properties. The functional components of C. cicadae are adenosine, N(6)-(2-Hydroxyethyl) adenosine (HEA), and polysaccharides [6,7], which are proven to have antioxidation, anti-inflammatory, and anti-aging properties [8].…”

Section: Introductionmentioning

confidence: 99%

Cordyceps cicadae NTTU 868 Mycelium with The Addition of Bioavailable Forms of Magnesium from Deep Ocean Water Prevents the Aβ40 and Streptozotocin-Induced Memory Deficit via Suppressing Alzheimer’s Disease Risk Factors and Increasing Magnesium Uptake of Brain

Lee

2021

Fermentation

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Alzheimer’s disease (AD) is a common neurodegenerative disease characterized by continuous accumulation of β-amyloid (Aβ) in the brain. Deep ocean water (DOW) with rich inorganic salts and minerals was proven to promote fungi growth and metabolism. Cordyceps cicada, a functional food fungus, can produce higher anti-oxidant and anti-inflammatory compounds including adenosine, polysaccharide, and N(6)-(2-Hydroxyethyl) adenosine (HEA). This study used DOW as the culture water of C. cicadae NTTU 868 for producing DOW-cultured C. cicadae (DCC), and further investigated the effects and mechanisms on improving the memory deficit and repressing risk factors expressions in Aβ40 and streptozotocin (STZ)-induced Alzheimer’s disease rats model. In the results, DCC including mycelium and filtrate had adenosine, HEA, polysaccharide, and intracellular Mg2+ after fermentation with DOW. DCC had more effect on the improvement of memory deficit because it suppressed Aβ40 and streptozotocin (STZ) infusion caused BACE, pro-inflammatory factors expressions, and Aβ40 accumulation by increasing sRAGE expression in the brain. Furthermore, DCC enhanced the MAGT1 expression due to high organic magnesium, which can reverse Aβ40-induced cortex magnesium deficiency and further repress Aβ40 accumulation.

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“…As a noted traditional Chinese medicine, cicada flowers have been applied in therapies for fatigue, night perspiration, fever, childish convulsion, palpitation, and dizziness for a long time. In addition, modern pharmacological research has demonstrated that cicada flowers possess antitumor, antifatigue, anti-inflammatory, immunomodulatory, analgesic, , renoprotective, and sedative properties. , Many bioactive compounds, including polysaccharides, , myriocin, ergosterol peroxide, and nucleosides, have been isolated from cicada flowers.…”

Section: Introductionmentioning

confidence: 99%

“…The wild cicada flowers are in great market demand nowadays because of their potent bioactivities, but they are expensive because of their rarity in nature and the difficulty of artificial cultivation. To satisfy the large consumption demand of cicada flowers, two major artificial culture techniques, solid-state fermentation and submerged fermentation, have been developed . However, several studies have reported that constituent differences exist between the fermented products of Isaria cicadae and wild cicada flowers .…”

Section: Introductionmentioning

confidence: 99%

Promotion of Metabolite Synthesis in Isaria cicadae, a Dominant Species in the Cicada Flower Microbiota, by Cicada Pupae

Chunyu

Lü

Luo

et al. 2019

J. Agric. Food Chem.

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Cicada flowers, which are edible and medicinal mushrooms, are the fruiting bodies of Isaria cicadae, a fungus that is parasitic on the larvae of cicada pupae. We hypothesize that host factors might possess stimulatory activity on metabolite synthesis in Isaria cicadae. Here, we first compared the microbial community structures of different wild cicada flowers across geographical regions, compartments, and growth stages via high-throughput sequencing. Isaria cicadae TZC-3, an isolate of the most abundant operational taxonomic unit (OTU6782) in all the fungal communities, was isolated from wild cicada flowers. Furthermore, the effects of cicada pupae on metabolite synthesis in Isaria cicadae TZC-3 were studied in submerged culture. The contents of intercellular polysaccharides, adenosine, N6-(2-hydroxyethyl)-adenosine, free amino acids, and hydrolyzed monosaccharides in the mycelia cultured with cicada pupa powder (4%) were significantly increased as compared with the contents in the control group. This indicates that a cicada pupa can act as an elicitor for metabolite synthesis in Isaria cicadae.

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Chemical Constituents of Cordyceps cicadae

Cited by 9 publications

References 12 publications

Bioactive Metabolites and Potential Mycotoxins Produced by Cordyceps Fungi: A Review of Safety

Bioactive Metabolites and Potential Mycotoxins Produced by Cordyceps Fungi: A Review of Safety

Cordyceps cicadae NTTU 868 Mycelium with The Addition of Bioavailable Forms of Magnesium from Deep Ocean Water Prevents the Aβ40 and Streptozotocin-Induced Memory Deficit via Suppressing Alzheimer’s Disease Risk Factors and Increasing Magnesium Uptake of Brain

Promotion of Metabolite Synthesis in Isaria cicadae, a Dominant Species in the Cicada Flower Microbiota, by Cicada Pupae

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