Chemical Constituents of Ficus drupacea Leaves and Their α-Glucosidase Inhibitory Activities

Kiệm, Phan Văn; Minh, Châu Văn; Nhiệm, Nguyễn Xuân; Yến, Phạm Hải; Anh, Hoang Le Tuan; Cường, Nguyễn Xuân; Tài, Bùi Hữu; Quang, Trần Hồng; Hải, Trương Nam; Kim, Seung Hyun; Kwon, Se Uk; Lee, Young Mi; Kim, Young Ho

doi:10.5012/bkcs.2013.34.1.263

Cited by 14 publications

(13 citation statements)

References 17 publications

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“…Epilupeol ( 5 ), however, has been less studied, although its anti-inflammatory [37], antitubercular [38], and cytotoxic [39] activities have been described. 3-epilupeol acetate ( 3 ) has been reported to have α-glucosidase inhibitory activity [40]. 3-epilupeol formiate ( 1 ), was reported as constituent of Boswellia carterii [18], and until now there is not reports about its biological activity.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and antioxidative effects of six pentacyclic triterpenes isolated from the Mexican copal resin of Bursera copallifera

Romero-Estrada

Maldonado-Magaña

González-Christen

et al. 2016

BMC Complement Altern Med

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Background Bursera copallifera (Burseraceae) releases a resin known as “copal ancho” which has been used, since pre-Colombian times, as ceremonially burned incense and to treat tooth ache, tumors, arthritis, cold, cough, and various inflammatory conditions; however, its anti-inflammatory potential is poorly studied. The aim of the present study was to isolate, quantify, and to investigate the anti-inflammatory activity of triterpene compounds isolated from the copal resin of B. copallifera.MethodsThe constituents present in the total resin of B. copallifera were obtained by successive chromatographic procedures, and quantitative analysis was performed by High Performance Liquid Chromatography (HPLC). Anti-inflammatory effects of the isolated triterpenes were investigated to determine their inhibitory effects on phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced edema in mice, viability and nitric oxide (NO) production inhibition on lipopolysaccharide (LPS)-activated RAW 264.7 macrophages, and inhibition of cyclooxygenase (COX)-1, COX-2 and secretory Phospholipase A2 (sPLA2) activities in vitro.ResultsQuantitative phytochemical analysis of the copal resin showed the presence of six pentacyclic triterpenes of which, 3-epilupeol (59.75 % yield) and α-amyrin (21.1 % yield) are the most abundant. Among the isolated triterpenes, 3-epilupeol formiate (Inhibitory Concentration 50 % (IC50) = 0.96 μmol), α.amyrin acetate (IC50 = 1.17 μmol), lupenone (IC50 = 1.05 μmol), and 3-epilupeol (IC50 = 0.83 μmol) showed marked inhibition of the edema induced by TPA in mice. α-amyrin acetate and 3-epilupeol acetate, at 70 μM, also inhibited the activity of COX-2 by 62.85 and 73.28 % respectively, while α-amyrin and 3-epilupeol were the best inhibitors of the production of NO in LPS-activated RAW 264.7 cells with IC50 values of 15.5 and 8.98 μM respectively, and did not affected its viability. All compounds moderately inhibited the activity of PLA2.ConclusionsThis work supports the folk use of B. copallifera and provides the basis for future investigations about the therapeutic use of this resin in treating inflammation.

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and antioxidative effects of six pentacyclic triterpenes isolated from the Mexican copal resin of Bursera copallifera

Romero-Estrada

Maldonado-Magaña

González-Christen

et al. 2016

BMC Complement Altern Med

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“…Fractionation of a methanol extract from the leaves of F. microcarpa yielded a new C-glucosylflavone, ficuflavoside (108), and a new megastigmane glycoside, ficumegasoside (109). 68) Megastigmane dihydroalangionoside A (110) was also isolated for the first time from natural sources. 68) The isolation of a megastigmane, sodium 4′-dihydrophaseate (111) was reported from F. drupacea, together with a new benzenediol glucoside, 1,4-di-O-β-glucopyranosyl-2-(1,1-dimethylporpenyl) benzene (112).…”

Section: The Genus Ficus (Moraceae Family)mentioning

confidence: 99%

“…68) Megastigmane dihydroalangionoside A (110) was also isolated for the first time from natural sources. 68) The isolation of a megastigmane, sodium 4′-dihydrophaseate (111) was reported from F. drupacea, together with a new benzenediol glucoside, 1,4-di-O-β-glucopyranosyl-2-(1,1-dimethylporpenyl) benzene (112). 69) Another new megastigmane glycoside, ficalloside (113) was isolated from a methanol extract of the leaves of F. callosa.…”

Section: The Genus Ficus (Moraceae Family)mentioning

confidence: 99%

“…68) The isolation of a megastigmane, sodium 4′-dihydrophaseate (111) was reported from F. drupacea, together with a new benzenediol glucoside, 1,4-di-O-β-glucopyranosyl-2-(1,1-dimethylporpenyl) benzene (112). 69) Another new megastigmane glycoside, ficalloside (113) was isolated from a methanol extract of the leaves of F. callosa. 70) New compounds obtained from F. elastica include sodium (1′S,6′R)-8-O-β-D-glucopyranosyl abscisate (114) and ficuselastic acid (115).…”

Section: The Genus Ficus (Moraceae Family)mentioning

confidence: 99%

“…25) Ficuflavoside (108) exhibited potent peroxyl radical-scavenging activity at the concentrations of 2.0 µM compared with the positive control, Trolox. 68) 3.7. Osteoblast Differentiation Assay Direct stimulatory effect on osteoblast differentiation is an assay used to identify potential therapeutic molecules against bone diseases such as osteoporosis.…”

Section: Potential Candidates For Drug Discoverymentioning

confidence: 99%

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New Compounds and Potential Candidates for Drug Discovery from Medicinal Plants of Vietnam

Giang

Otsuka

2018

Chem. Pharm. Bull.

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The study of natural products introduces interesting new bioorganic structures and potential candidates for the drug discovery stage in the development of innovative drugs. Vietnam enjoys a broad biodiversity of native plant species, microorganisms, marine organisms, and a long tradition of using herbal remedies. Thus, the study of medicinal plants in determining the basis of their efficacy and safety is an important task for modern researchers in Vietnam. The present review covers literature on new compounds elucidated from the systematic study of medicinal plants within some popular genera in Vietnam, as well as their significant biological activities.

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Plant Secondary Metabolites with α-Glucosidase Inhibitory Activity

Gao

Qin

et al. 2021

Structure and Health Effects of Natural Products on Diabetes Mellitus

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Chemical Constituents of Ficus drupacea Leaves and Their α-Glucosidase Inhibitory Activities

Cited by 14 publications

References 17 publications

Anti-inflammatory and antioxidative effects of six pentacyclic triterpenes isolated from the Mexican copal resin of Bursera copallifera

Anti-inflammatory and antioxidative effects of six pentacyclic triterpenes isolated from the Mexican copal resin of Bursera copallifera

New Compounds and Potential Candidates for Drug Discovery from Medicinal Plants of Vietnam

Plant Secondary Metabolites with α-Glucosidase Inhibitory Activity

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