Chemical constituents of Chinese red ginseng

Liú, Dan; Pu, She-Ban; Qian, Shan; Zhang, Jingyan

doi:10.4268/cjcmm20110418

Cited by 9 publications

(13 citation statements)

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“…By comparing the NMR data with those reported in the literature, the other known analogues were identified as simiarenol ( 6 ) [9], simiarenone ( 7 ) [10], 24-methylenecycoartanol ( 8 ) [11], cycloartenol ( 9 ) [12], lanosta-7,24-dien-3 β -ol ( 11 ) [13], lanosta-8,24-dien-3 β -ol ( 11 ) [14], and lupeol ( 12 ) [15].…”

Section: Resultsmentioning

confidence: 99%

New e:b-Friedo-Hopane Type Triterpenoids from Euphorbia peplus with Simiarendiol Possessing Significant Cytostatic Activity against HeLa Cells by Induction of Apoptosis and S/G2 Cell Cycle Arrest

et al. 2019

Molecules

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Seven rare e:b-friedo-hopane-type triterpenoids including four new (1–4) and three known (5–7) ones with 5 being first reported as a natural product, together with five other known triterpenoids (8–12), were isolated from the nonpolar fractions of the ethanolic extract of Euphorbia peplus. Structural assignments for these compounds were based on spectroscopic analyses and quantum chemical computation method. The structural variations for the C-21 isopropyl group, including dehydrogenation (1 and 3) and hydroxylation at C-22 (simiarendiol, 2), were the first cases among e:b-friedo-hopane-type triterpenoids. Simiarendiol (2) bearing a 22-OH showed significant cytostatic activity against HeLa and A549 human tumor cell lines with IC50 values of 3.93 ± 0.10 and 7.90 ± 0.31 μM, respectively. The DAPI staining and flow cytometric analysis revealed that simiarendiol (2) effectively induced cell apoptosis and arrested cell cycle at the S/G2 phases in a dose-dependent manner in HeLa cells.

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Section: Resultsmentioning

confidence: 99%

New e:b-Friedo-Hopane Type Triterpenoids from Euphorbia peplus with Simiarendiol Possessing Significant Cytostatic Activity against HeLa Cells by Induction of Apoptosis and S/G2 Cell Cycle Arrest

et al. 2019

Molecules

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“…The peak biomass was reached at a treatment time of 120 h and a concentration of 3 g/L. The results of Liu et al showed that the traditional Chinese medicine red ginseng treated with CA has better anti-fatigue properties and regulates immunity better than untreated varieties due to significant improvement in T-SOD, IL-2, and IgG and a decrease in MDA [ 28 ]. To increase the biomass content of P. igniarius , naphthalene AA and oleic acid were used as exogenous inducers by Zhu et al The authors screened the optimal compounds of media and significantly increased the mass of polysaccharides, causing them to reach the maximum values at concentrations of 0.2 mg/L and 1 g/L, respectively [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Citric Acid Changes the Fingerprint of Flavonoids and Promotes Their Accumulation in Phellinus igniarius (L.) Quél

Dong

Chen

et al. 2022

Life

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Phellinus igniarius is a valuable medicinal fungus. P. igniarius is rich in a variety of chemical compounds with medicinal value, among which are flavonoids. Therefore, increasing the content of flavonoids in P. igniarius is beneficial for its potential use in medicinal applications. This study demonstrated that exogenous treatment with citric acid (CA) could significantly increase flavonoid accumulation in P. igniarius. Additionally, we found that CA induced the biosynthesis of flavonoids in a concentration- and time-dependent manner. The flavonoid content could be increased up to 60.96 mg/g when using the treatment with 2.77 mM citric acid for 69.74 h, which was determined by using the response surface method. The changes in the fingerprint profiles of P. igniarius flavonoids with the treatment of CA as an exogenous inducer were also analyzed. In this study, the effect of citric acid as the exogenous inducer on the flavonoid content of P. igniarius was studied, and the processing conditions were optimized through the surface response curve. This approach provides novel insights and a theoretical basis for the production of high-quality P. igniarius.

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“…Ancient and modern physicians have used it not only to improve the mental malaise, fatigue, and hypoimmunity of subhealthy individuals but also to treat severe diseases with a sharp decline in immunity, such as malignant tumors. Further study on the molecular mechanism of PG–AM in an immunosuppressed mouse model combining immunology and HPLC–ESI (electrospray ionization)–Q‐TOF–MS–based metabolomics (Liu, 2018a) has indicated that the scientific principle of metabolomics after the compatibility of PG–AM is that the metabolic pathways in the body are more likely to involve sphingolipids and glycerophospholipids and that the metabolism of bone marrow is more conservative than that of plasma. In another study (Liu et al, 2020), accumulating evidence of PG–AL on propafenone hydrochloride–induced acute heart failure rats has indicated that the absorption and bioavailability of four alkaloids, uracil, salsolinol, guanosine, and higenamine, increased and the residence time was prolonged after AL was combined with PG.…”

Section: Application Of Metabolomics In the Clinical Study Of Ginsengmentioning

confidence: 99%

“…Compared with the traditional product ion scan (PIS)‐based survey scanning strategy, high‐precision MS data can identify ginsenosides more reliably, laying a foundation to classify non‐targeted identification of ginsenosides. In addition, further study on the roots, leaves, and flower buds of PG, PQ, and PN revealed that LTQ–Orbitrap MS coupled to UHPLC could provide an effective analytical strategy to directly and effectively screen modified metabolites (Shi et al, 2018), with potential broad applications in the fields of metabolomics, drug metabolism, and natural product research (Li, 2020). These results will be helpful for the quality evaluation and species certification of ginseng in the future.…”

Section: Application Of Metabolomics In the Quality Evaluation Of Gin...mentioning

confidence: 99%

Research progress on metabolomics in the quality evaluation and clinical study ofPanax ginseng

Xia

Sun

Wen

et al. 2022

Biomedical Chromatography

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Panax ginseng, an essential component of traditional medicine and often referred to as the king of herbs, has played a pivotal role in medicine globally for several millennia. Previously, traditional phytochemical methods were mainly used for quality evaluation and pharmacological mechanism studies of ginseng, resulting in the lack of systematicness and innovation and hindering the development and utilization of ginseng resources. Since the beginning of the new century, systems biology technology represented by metabolomics has shown unique advantages in the modernization and internationalization of herbal medicine, establishing a bridge for communication between traditional medicine and modern medicine. P. ginseng, a special herb used in medicine and food, is one of the main research objects for qualitative and quantitative analysis of metabolomics and has gradually become the focus of researchers globally. Here, we conducted a comprehensive summary and analysis of numerous studies published in ginseng metabolomics. This review aims to provide more novel ideas for the quality evaluation, development, and clinical application of ginseng in the future and offer more useful technical references for the modernization and internationalization of herbal medicine based on metabolomics.

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Chemical constituents of Chinese red ginseng

Cited by 9 publications

References 0 publications

New e:b-Friedo-Hopane Type Triterpenoids from Euphorbia peplus with Simiarendiol Possessing Significant Cytostatic Activity against HeLa Cells by Induction of Apoptosis and S/G2 Cell Cycle Arrest

New e:b-Friedo-Hopane Type Triterpenoids from Euphorbia peplus with Simiarendiol Possessing Significant Cytostatic Activity against HeLa Cells by Induction of Apoptosis and S/G2 Cell Cycle Arrest

Citric Acid Changes the Fingerprint of Flavonoids and Promotes Their Accumulation in Phellinus igniarius (L.) Quél

Research progress on metabolomics in the quality evaluation and clinical study ofPanax ginseng

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