“…Significantly, they have been used as traditional Chinese folk herbs to treat many sorts of illnesses . Phytochemical studies in the past decades provided a large group of polycyclic diterpenes (around 1000 members), namely, Euphorbia diterpenes, which have displayed broad-spectrum and promising therapeutically relevant biological activities like antitumor, antiviral, anti-inflammatory, and multidrug-resistance reversing (MDR) . A typical example is the FDA-approved marketed pharmaceutical ingenol mebutate (Picato), used as a first-in-class treatment for actinic keratosis, a precancerous skin condition …”