Chemical constituents of Cardiospermum corindum L. and their distribution in Sapindaceae

Silva, Fabiana Lima; Moreno, Paulo Roberto Hrihorowitsch; Braz-Filho, Raimundo; Tavares, Josean Fechine; Barbosa-Filho, José Maria

doi:10.1016/j.bse.2014.07.021

Cited by 13 publications

(6 citation statements)

References 24 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4d). Besides, all the isolated compounds (1)(2)(3)(4)(5)(6) and CCE showed a very mild degree of specificity against NHME which indicates that the samples are non-toxic to normal human cells.…”

Section: Anticancer Activitymentioning

confidence: 99%

“…Biologically, the whole plant of C. canescens reported for arthritis, lumbago, neuropathy, fever, stiffness of limbs, piles, nervous disorders, neuropathy, diaphoretic, snake bites, laxative, diuretic, emmenagogue, and mucilaginous [4]. Earlier, a series of phytochemical constituents, namely flavonoids, triterpenoids, saponins, carbohydrates, proteins, alkaloids, and tannins was identified from C. canescens [4,5]. To date, antioxidant, antibacterial, hepatoprotective effects, and cytotoxicity activities were investigated on C. canescens [1,3,5,6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In vitro antioxidant, anti-inflammatory, and anticancer activities of methanolic extract and its metabolites of whole plant Cardiospermum canescens Wall

2020

View full text Add to dashboard Cite

Background: Traditionally, the whole plant of Cardiospermum canescens has wide applications in the management of oxidative stress and inflammation in Africa and Asia. The present study investigated the antioxidant, antiinflammatory, xanthine oxidase (XO) inhibitory, and anticancer activities of metabolites present in the crude methanolic extract of whole plant C. canescens (CCE). Results: Chemical examination of CCE revealed the presence of six known compounds (1-6). From the results of in vitro studies, it can confirm that CCE exhibited notably inhibition of DPPH and superoxide free radicals, along with COX-1, COX-2, 5-LOX, and XO enzymes. Compounds 2 and 3 showed significant inhibition of DPPH and superoxide free radicals. Also, compound 2 exhibited good inhibition of COX-1 and COX-2 enzyme with IC 50 of 87.0 and 88.0 μg/mL. Furthermore, CCE exhibited significant inhibition of 5-LOX and XO enzymes with IC 50 of 42.5 and 56.0 μg/mL, respectively, while standard with IC 50 of 42.5 and 56.0 μg/mL, respectively. Among the test series of cancer cell lines, compounds 2, 3, and CCE showed a significant percentage of cell growth lysis of DLD-1 with IC 50 values of 52.5, 72.5, and 32.5 μg/mL, respectively. Besides, all the metabolites and CCE showed a very weak degree of specificity against NHME, indicates less toxicity to normal cells. Conclusion: To conclude, the results of the present study indicated that the methanolic extract from the whole plant of C. canescens displayed antioxidant activity by inhibiting DPPH and superoxide free radicals; antiinflammatory effects by regulating enzymes COX-1, COX-2, 5-LOX, and XO; and anticancer activity by inhibiting the growth of MCF-7, DLD-1, HeLa, and A549. These activities can link to natural active compounds 2 and 3. This study supports the traditional uses of the root of C. canescens. These data findings suggest that C. canescens can be a promising natural source of biological medicines for oxidative stress, inflammation, gout, and cancer.

show abstract

Section: Anticancer Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro antioxidant, anti-inflammatory, and anticancer activities of methanolic extract and its metabolites of whole plant Cardiospermum canescens Wall

2020

View full text Add to dashboard Cite

show abstract

“…However, this is the first report of the isolation of quercetin 3-O-arabinopyranoside, kaempferol 3-O-arabinopyranoside, and quercetin 3-O-β-D-glucoside from the plant leaves. Chemosystematics of the Sapindaceae shows that the family is rich in flavonoids [21,22]. The leaves of plants belonging to the Sapindaceae have been reported to contain flavones, flavonols, including Oand C-glycosides, and proanthocyanidins [21,23].…”

Section: Chemistrymentioning

confidence: 99%

Antiplasmodial and Cytotoxic Flavonoids from Pappea capensis (Eckl. & Zeyh.) Leaves

et al. 2021

View full text Add to dashboard Cite

Ethnobotanical surveys indicate that the Masai and Kikuyu in Kenya, the Venda in South Africa, and the Gumuz people of Ethiopia use Pappea capensis for the treatment of malaria. The present study aimed to investigate the phytochemical and antiplasmodial properties of the plant leaves. The bioactive compounds were isolated using chromatographic techniques. The structures were established using NMR, HRMS, and UV spectroscopy. Antiplasmodial activity of P. capensis leaf extract and isolated compounds against chloroquine-sensitive 3D7 P. falciparum was evaluated using the parasite lactate dehydrogenase assay. Cytotoxicity against HeLa (human cervix adenocarcinoma) cells was determined using the resazurin assay. The extract inhibited the viability of Plasmodium falciparum by more than 80% at 50 µg/mL, but it was also cytotoxic against HeLa cells at the same concentration. Chromatographic purification of the extract led to the isolation of four flavonoid glycosides and epicatechin. The compounds displayed a similar activity pattern with the extract against P. falciparum and HeLa cells. The results from this study suggest that the widespread use of P. capensis in traditional medicine for the treatment of malaria might have some merits. However, more selectivity studies are needed to determine whether the leaf extract is cytotoxic against noncancerous cells.

show abstract

“…Cardiospermum genus belongs to the family Sapindaceae and comprises of about 16 species, which are widely distributed throughout the world. [ 1 ] Being a member of the Cardiospermum species, Cardiospermum halicacabum L., a climbing plant, is broadly developed in tropical and subtropical Africa and Asia. C. halicacabum is popularly employed in the treatment of fever, nervous, diuretic, gastroenteritis, rheumatism, and lumbago diseases.…”

Section: Introductionmentioning

confidence: 99%

Flavonoid from the aerial parts of Cardiospermum halicacabum L.

Linh,

Cham,

Anh

et al. 2023

Vietnam Journal of Chemistry

View full text Add to dashboard Cite

The first chemical investigation on Cardiospermum halicacabum L. growing in Vietnam led to the isolation and structural determination of nine flavonoid compounds, including quercetin 3‐O‐β‐D‐glucoside (1), quercetin 3‐O‐α‐L‐rhamnoside (2), quercetin (3), kaempferol 3‐O‐α‐L‐rhamnoside (4), kaempferol (5), apigenin 7‐O‐β‐D‐glucuronide butyl ester (6), apigenin 7‐O‐β‐D‐glucuronide methyl ester (7), apigenin (8), and luteolin (9). Their structures were established by using HR ESI MS, 1D and 2D NMR spectroscopic methods and comparison with those of the related published data. With exceptions to flavonoids 3 and 8, the rest seven compounds (1‐2, 4‐7, and 9) were found for the first time from this plant. Notably, two rare flavonoids (6 and 7) have not yet been reported from the Sapindaceae family before.

show abstract

Chemical constituents of Cardiospermum corindum L. and their distribution in Sapindaceae

Cited by 13 publications

References 24 publications

In vitro antioxidant, anti-inflammatory, and anticancer activities of methanolic extract and its metabolites of whole plant Cardiospermum canescens Wall

In vitro antioxidant, anti-inflammatory, and anticancer activities of methanolic extract and its metabolites of whole plant Cardiospermum canescens Wall

Antiplasmodial and Cytotoxic Flavonoids from Pappea capensis (Eckl. & Zeyh.) Leaves

Flavonoid from the aerial parts of Cardiospermum halicacabum L.

Contact Info

Product

Resources

About