Chemical constituents of Abies fabri

Li, Yongli; Gao, Youguang; Jin, Hui‐Zi; Shan, Lei; Chang, Wanlin; Yang, Xian‐Wen; Zeng, Hua‐Wu; Wang, Ning; Steinmetz, André; Zhang, Guoqing

doi:10.1016/j.phytochem.2015.06.012

Cited by 26 publications

(15 citation statements)

References 22 publications

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“…149 Juniperigiside (406) was reported from the CHCl 3 soluble fraction of the methanol extract of stem and leaves of the medicinal plant Juniperus rigida (Cupressaceae) 150 while compound 407 was obtained from Abies fabri (Pinaceae). 151 The dihydrobenzofuranoid neolignan bearing a 1,3,4,5-tetrasubstituted benzene ring ococymosin (408) was characterized from the stem or bark of the Madagascan plant Ocotea cymosa (Lauraceae). 152 It exhibited antiparasitic activity against the Dd2 strain of Plasmodium falciparum with an IC 50 of 0.45 mM.…”

Section: Benzofuransmentioning

confidence: 99%

Recent advances in research on lignans and neolignans

2016

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Covering: 2009 to 2015Lignans and neolignans are a large group of natural products derived from the oxidative coupling of two C6-C3 units. Owing to their biological activities ranging from antioxidant, antitumor, anti-inflammatory to antiviral properties, they have been used for a long time both in ethnic as well as in conventional medicine. This review describes 564 of the latest examples of naturally occurring lignans and neolignans, and their glycosides in some cases, which have been isolated between 2009 and 2015. It comprises the data reported in more than 200 peer-reviewed articles and covers their source, isolation, structure elucidation and bioactivities (where available), and highlights the biosynthesis and total synthesis of some important ones.

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Section: Benzofuransmentioning

confidence: 99%

Recent advances in research on lignans and neolignans

2016

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“…The absolute configuration of C-17 and C-23 has an important bearing on chemical shifts of C-20, C-22, and C-24 due to the anisotropic effect of the lactone oxygen atom. The 13 C NMR chemical shifts of C-20, C-22, and C-24 for (17 S ,23 S )-isomer were almost equal, however, those of (17 S ,23 R ), (17 R ,23 S ), and (17 R ,23 R )-isomers showed dramatical differences larger than 5 ppm [ 12 , 13 ]. Therefore, the absolute configurations of C-17 and C-23 for 1 were highly close to that of (17 S ,23 S )-isomer reported in the literature [ 12 ], and both determined to be S -configuration based on comparison of NMR spectroscopic data (C-20 ( δ C 43.4), C-22 ( δ C 44.6), and C-24 ( δ C 44.9)) with those of similar structures.…”

Section: Resultsmentioning

confidence: 99%

“…The 13 C NMR chemical shifts of C-20, C-22, and C-24 for (17 S ,23 S )-isomer were almost equal, however, those of (17 S ,23 R ), (17 R ,23 S ), and (17 R ,23 R )-isomers showed dramatical differences larger than 5 ppm [ 12 , 13 ]. Therefore, the absolute configurations of C-17 and C-23 for 1 were highly close to that of (17 S ,23 S )-isomer reported in the literature [ 12 ], and both determined to be S -configuration based on comparison of NMR spectroscopic data (C-20 ( δ C 43.4), C-22 ( δ C 44.6), and C-24 ( δ C 44.9)) with those of similar structures. The Me-21 and Me-27 were assigned as α - and β -orientation, respectively, based on the ROESY correlations of H-18 ( δ H 1.15) with H-20 ( δ H 2.14), H-24 α ( δ H 2.36) with H-21 ( δ H 0.91) and H-25 ( δ H 3.02), and H-24 β ( δ H 1.96) with H-27 ( δ H 1.23).…”

Section: Resultsmentioning

confidence: 99%

“…It is rare that such an oxaspirolactone moiety ring occurred in the lanostane-type triterpenoids. At present, no more than 40 lanostane-type triterpenoids isolated from natural products possessed such an oxaspirolactone moiety [ 12 , 13 , 21 ]. We proposed that compounds 1 – 4 and 8 were biogenetically derived from lanosterol derived by the mevalonic acid pathway.…”

Section: Discussionmentioning

confidence: 99%

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Isolation, Structural Elucidation, and α-Glucosidase Inhibitory Activities of Triterpenoid Lactones and Their Relevant Biogenetic Constituents from Ganoderma resinaceum

et al. 2018

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Ganoderma resinaceum has been used as an ethnomedicine for lowering blood sugar. To clarify the bioactive chemical constituents contributing to lower blood sugar, chemical investigation on the fruiting bodies of Ganoderma resinaceum was conducted by chromatographic techniques, and led to the isolation of 14 compounds. Their structures were elucidated as triterpenoid lactones (1–4 and 8) and ganoderma acids (5–7 and 9–14) based on the analysis of extensive spectroscopy (mass spectrometry (MS), nuclear magnetic resonance (NMR), infrared (IR), and ultraviolet (UV)) and comparison with literature data. Compounds 3, 5, 6, and 9–14 were evaluated for α-glucosidase inhibitory activity. Compounds 1–7 are new compounds. Compounds 1–4 and 8 were characteristic of an oxaspirolactone moiety, consisting of a five-membered ether ring, a five-membered lactone ring, and a characteristic C-23 spiro carbon. It is rare for natural products that such an oxaspirolactone moiety occurred in the lanostane-type triterpenoids. Compounds 5–7 and 9–14 may be important intermediates of the biosynthetic pathways of 1–4 and 8. Compounds 1 and 2 showed more potent inhibitory activity against α-glucosidase compared with the positive control drug acarbose with IC50 value of 0.75 ± 0.018 mM and 1.64 ± 0.022 mM, respectively.

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“…Therefore, the use of medicinal plants implies a promising perspective for the treatment of MC. When determining the chemical composition and structure of active substances of medicinal plants and their medications by using modern high-precision methods (Makarova et al, 2013;Yong-Li et al, 2015), it was established that the essential oils of plants include various chemicals, for example, thymol, foams, and cineoles. A large number of terpenoids and terpenes provide oils with geroprotective properties and promote the regeneration of tissues (Kudryavtseva et al, 2016;Wenming et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Needles of Abies Sibirica in the Treatment of Subclinical Mastitis in Cows

Danilov¹,

Valitova²,

Vorobyov³

et al. 2019

Journal of Livestock Science

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Study of the therapeutic effectiveness of ''Abies-masti'', a medication based on Siberian fir needles, in the treatment of subclinical mastitis in cows. The therapeutic effectiveness of the medication was studied in cows with subclinical mastitis. ''Abies-masti'' was rubbed into the skin of the inflamed lobes twice a day after milking until the clinical recovery of the cows. Hematological blood tests, as well as the examination of milk samples from the affected parts of the udder before the treatment and in 5 and 12 days from the beginning of the treatment were carried out according to the methods generally accepted in veterinary practice. The authors of the research established that when using the medication ''Abiesmasti'' to treat cows with subclinical mustitis, the clinical recovery of animals under production conditions was achieved within 3.14 ± 0.26 days. The therapeutic effectiveness of ''Abies-masti'' was 91.4-92.6%. The authors proved that the normalization of the hematological parameters, as well as the organoleptic, physico-chemical, and microbiological indicators of milk occurs on the 5th day from the beginning of the treatment. The cost of the treatment amounted to $ 0.45 per animal. The restoration of the functional state of the mammary gland and the recovery of cows with the use of the given phytomedication is achieved within a shorter period than with the help of other anti-mastitis medications. 48 hours after the last application of the medication, the milk of the recovered animals fully meets the requirements of GOST. The result is achieved thanks to the composition of the medication and the properties of its components, which have a bactericidal effect against the causative agent, increase the protective forces of the macroorganism and ensure the stability of the therapeutic effect. The authors of the research prove the effectiveness and expediency of using this medication based on Siberian fir needles for the treatment of subclinical mastitis in cows.

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Chemical constituents of Abies fabri

Cited by 26 publications

References 22 publications

Recent advances in research on lignans and neolignans

Recent advances in research on lignans and neolignans

Isolation, Structural Elucidation, and α-Glucosidase Inhibitory Activities of Triterpenoid Lactones and Their Relevant Biogenetic Constituents from Ganoderma resinaceum

Needles of Abies Sibirica in the Treatment of Subclinical Mastitis in Cows

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