Chemical constituents in the essential oil of the endemic plant Cotula cinerea (Del.) from the southwest of Algeria

Djellouli, Mohammed; Benmehdi, Houcine; Mammeri, Siham; Moussaoui, A.; Ziane, Laid; Hamidi, Noureddine

doi:10.1016/j.apjtb.2015.06.007

Cited by 22 publications

(24 citation statements)

References 14 publications

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“…In the last decades, there has been particular interest in the use of abundant naturally occurring antimicrobials (herbs, spices and plants). This result concurred with Tekwu et al [30] and Djellouli et al [31] who reported that chloroform fraction derived from the methanol extract of A. radiata was found to be most effective followed by ethyl acetate and butanol fractions. Some extracts showed weakly anticandidal activity [8].…”

Section: Antioxidant Activitysupporting

confidence: 91%

Antioxidant Activities, Phenolic, Flavonoid and Tannin Contents and Antibacterial Activity of Anvillea radiata (Coss. & Dur.) Flowers from Southeast Algeria

Mahdjar¹,

Dendougui²,

Hadjadj³

2019

Asian J. Chem.

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Anvillea garcinii subsp. radiata (Coss. & Dur.) are an endemic species of Sahara region especially in Morocco and Algeria. This plant is widely used in traditional medicine. The extraction of phenolic compounds from A. radiata flowers is carried out using solvents of different polarity (chloroform, ethyl acetate, butanol). The yields of extraction from the flowers were 19.34, 0.278, 0.149, 1.750 and 3.308 % for the crude, chloroform, ethyl acetate, butanol and aqueous extracts, respectively. The amount of total phenolics, flavonoids, tannins and in vitro antioxidant and antibacterial properties of extracts of A. radiata flowers. The antioxidant activities were evaluated by measuring the ability of the extracts to scavenge the DPPH, ferric reducing power FRAP and phosphomolybdenum assay. The maximum extractable total phenolics and flavonoids were recorded in ethyl acetate fraction, while the tannins were present in chloroform fraction. Among the five extracts of A. radiata flowers, the maximum DPPH free radical scavenging activity was shown in ethyl acetate and butanol fractions (IC50 = 0.20 ± 0.001 and 0.31 ± 0.004 mg/mL, respectively). The highest activity of FRAP assay and phosphomolybdenum reduction was observed in butanol fraction (358.58 ± 12.55 and 95.09 ± 0.67 mM, respectively). The results were compared with natural and synthetic antioxidants. In antibacterial properties, the chloroform extract has the highest activity. These results implied that these plant extracts may possess health promoting effects and might be potential sources of potent natural antioxidant and antimicrobial.

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Section: Antioxidant Activitysupporting

confidence: 91%

Antioxidant Activities, Phenolic, Flavonoid and Tannin Contents and Antibacterial Activity of Anvillea radiata (Coss. & Dur.) Flowers from Southeast Algeria

Mahdjar¹,

Dendougui²,

Hadjadj³

2019

Asian J. Chem.

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“…The physical properties of the essential oils have also been studied with respect to density, refractive index and rotatory power, resulting in values of 0.864, 1.4610 and +115°, respectively [24]. Moreover, numerous studies have been conducted on the composition of essential oils of C. cinerea essential oil from different geographical regions [24,[29][30][31][32][33]42]. The major chemical compounds present in C. cinerea essential oil from different regions are listed in Table 3 and Table 4.…”

Section: Phytochemistry Of C Cinereamentioning

confidence: 99%

Traditional uses, phytochemistry and biological activities of <i>Cotula cinerea</i> Del: A review

Lakhdar¹

2018

Trop. J. Pharm Res

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Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic, cough, diarrhea, digestive disorders, rheumatism, urinary and pulmonary infections, fever and headaches. Cotula cinerea contains a wide range of phytochemical compounds such as saponins, essential oils, tannins, flavonoids, steroids, and terpenoids. This paper reviews information pertaining its traditional uses, phytochemistry and biological activities such as antibacterial, antifungal, antioxidant, herbicidal, anti-diarrheal and analgesic properties. It is hoped that the information presented here might stimulate further studies that will possibly lead to development of therapeutic agents from this plant.

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“…Djellouli et al, 22 and Sieniawska et al, 28 have reported that trans-thujone (41.4%), cis-verbenyl acetate (24.7%), 1,8-cineole (8.2%) and camphor (5.5%) as the major components of the plants collected in Morocco, while Atef et al, 9 have reported that santolina triene (18.58%), thujone (21.73%), 3-carene (30.99%) and camphor (6.21%) as major constituents 24 . Current study has shown that the oil contains trans thujone (51.86%), santalina triéne (10.6%), α-pinéne (2.02%), sabinene (6.17%), cineole <1.8> (5.34%), δ -terpinene (1.57%), camphor (2.63%), β-terpineol (1.39%) and terpin-4-ol (1.73%) as the major constituents.…”

Section: Discussionmentioning

confidence: 98%

Phytochemical Characterization,In-VitroCytotoxic and Antibacterial Activity ofCotula cinerea(Delile) Vis Essential Oil

Larbi

Benchikha

Elsharkawy

et al. 2018

Journal of Natural Remedies

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Cotula cinerea is a traditional Algerian medicinal plant that has many biological properties, such as analgesic, antiseptic and antibacterial activities. Essential oil of Cotula cinerea was subjected to chromatographical and spectroscopical studies to determine the chemical composition. The analysis highlighted that the oil contains trans thujone (51.86%), santalina triéne (10.6%), α-pinéne (2.02%), sabinene (6.17%), cineole <1.8> (5.34%), δ-terpinene (1.57%), camphor (2.63%), β-terpineol (1.39 %) and terpin-4-ol (1.73%) as the major constituents. The essential oil was tested for antibacterial activity. The oil exhibited substantial antibacterial activity against both the tested Gram negative and Gram positive bacteria. In search of better anticancer agent the essential oil of Cotula cinerea was also subjected for in-vitro cytotoxic activity on two cancerous human cell lines; colon (HCT116) and hepatic (HePG2) cancer cell lines. The results indicates that the essential oil of Cotula cinerea has a significant cytotoxic activity on the tested colon cancer cell lines with a 66.9% inhibition and a minimal inhibition (33.9%) on liver cancer cell line.

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Chemical constituents in the essential oil of the endemic plant Cotula cinerea (Del.) from the southwest of Algeria

Cited by 22 publications

References 14 publications

Antioxidant Activities, Phenolic, Flavonoid and Tannin Contents and Antibacterial Activity of Anvillea radiata (Coss. & Dur.) Flowers from Southeast Algeria

Antioxidant Activities, Phenolic, Flavonoid and Tannin Contents and Antibacterial Activity of Anvillea radiata (Coss. & Dur.) Flowers from Southeast Algeria

Traditional uses, phytochemistry and biological activities of <i>Cotula cinerea</i> Del: A review

Phytochemical Characterization,In-VitroCytotoxic and Antibacterial Activity ofCotula cinerea(Delile) Vis Essential Oil

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