Chemical constituents from the stems and leaves of Amomum villosum Lour. and their anti-inflammatory and antioxidant activities

Gao, Chengfeng; Zhu, Man; Xu, Wei; Wang, Yali; Xiong, Liangliang; Sun, Dejuan; Sun, Minge; Yang, Lin; Li, Hua; Chen, Lixia

doi:10.1016/j.bioorg.2022.106281

Cited by 11 publications

(8 citation statements)

References 36 publications

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“…Our study revealed that A. villosum can increase GSH and GSH-Px levels, thereby restoring oxidative equilibrium and suggesting a potential therapeutic approach for alcoholic liver injury. These findings are consistent with those of Gao et al, whose study demonstrated that a notable compound from A. villosum markedly increased GSH levels in BV-2 cells by activating the nuclear factor erythroid-2 related factor 2/heme oxygenase 1 (NRF2/HO-1) pathways, indicating its efficacy in oxidative regulation (Gao et al, 2023).…”

Section: Discussionsupporting

confidence: 93%

Network medicine‐based analysis of the hepatoprotective effects of Amomum villosum Lour. on alcoholic liver disease in rats

Wei,

Wang,

Huang

et al. 2024

Food Science & Nutrition

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Alcoholic liver disease (ALD) is characterized by high morbidity and mortality, and mainly results from prolonged and excessive alcohol use. Amomum villosum Lour. (A. villosum), a well‐known traditional Chinese medicine (TCM), has hepatoprotective properties. However, its ability to combat alcohol‐induced liver injury has not been fully explored. The objective of this study was to investigate the hepatoprotective effects of A. villosum in a rat model of alcohol‐induced liver disease, thereby establishing a scientific foundation for the potential preventive use of A. villosum in ALD. We established a Chinese liquor (Baijiu)‐induced liver injury model in rats. Hematoxylin and eosin (HE) staining, in combination with biochemical tests, was used to evaluate the protective effects of A. villosum on the liver. The integration of network medicine analysis with experimental validation was used to explore the hepatoprotective effects and potential mechanisms of A. villosum in rats. Our findings showed that A. villosum ameliorated alcohol‐induced changes in body weight, liver index, hepatic steatosis, inflammation, blood lipid metabolism, and liver function in rats. Network proximity analysis was employed to identify 18 potentially active ingredients of A. villosum for ALD treatment. These potentially active ingredients in the blood were further identified using mass spectrometry (MS). Our results showed that A. villosum plays a hepatoprotective role by modulating the protein levels of estrogen receptor 1 (ESR1), anti‐nuclear receptor subfamily 3 group C member 1 (NR3C1), interleukin 6 (IL‐6), and tumor necrosis factor‐α (TNF‐α). In conclusion, the results of the current study suggested that A. villosum potentially exerts hepatoprotective effects on ALD in rats, possibly through regulating the protein levels of ESR1, NR3C1, IL‐6, and TNF‐α.

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Section: Discussionsupporting

confidence: 93%

Network medicine‐based analysis of the hepatoprotective effects of Amomum villosum Lour. on alcoholic liver disease in rats

Wei,

Wang,

Huang

et al. 2024

Food Science & Nutrition

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“…Apart from compounds 1-3, 7 known diterpenoids were isolated and identified as (12Z,14R)-labda-8(17),12-diene-14,15,16-triol (4), [6] (12S)-hydroxy-15ξ-methoxy-labda-8(17),13( 14)-dien-15,16-olide (5), [24] isocoronarin D (6), [25] (+)-(5S,9S,10S)-(E)-labda-8(17),12-diene-15,16-dioic acid (7), [26] longpene A (8), [27] coronadiene (9) [28] and amomum C (10), [20] by comparing their chemical evidences and NMR data with those reported in the literatures.…”

Section: Resultsmentioning

confidence: 99%

“…In continuation of phytochemical study on A. villosum, [20] herein we reported the isolation and characterization of three new labdane-type diterpenoids, calcaratarin E (1), villosumtriol (2), 12-epi-villosumtriol (3) and 7 known diterpenoids (4-10) (Figure 1). We also tested their inhibitory effects on NO production in LPS-induced RAW264.7 cells.…”

Section: Introductionmentioning

confidence: 94%

Three New Labdane‐Type Diterpenoids from the Fruits of Amomum villosum and Their Anti‐Inflammatory Activities

Zhang

Liu

et al. 2023

Chemistry & Biodiversity

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Three new labdane‐type diterpenoids, calcaratarin E, villosumtriol, and 12‐epi‐villosumtriol (1‐3) were isolated from the fruits of Amomum villosum, along with seven known diterpenoids (4‐10). Through comprehensive analysis of chemical evidence and spectral data including UV, 1D and 2D NMR, HR‐ESI‐MS, IR, and X‐ray crystallography, the structures of these novel compounds were successfully determined. Additionally, the inhibitory effects of compounds 2‐10 on NO production in lipopolysaccharide (LPS)‐induced RAW264.7 cells were evaluated. Notably, compound 6 exhibited the most significant inhibitory effect with an IC50 value of 1.74 ± 0.69 μM.

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“…Liao et al (2023) isolated and identified the specific binding components of Huanglian Jiedu Decoction to human umbilical vein endothelial cells by a combination of UPLC-Orbitrap-MS and found 13 active components such as geniposide, thapsigin, baicalin, and berberine as pharmacodynamic components that promote angiogenesis. Gao et al (2023) isolated and identified 45 compounds from the leaves of Amomumvillosum Lour., with the help of HPLC-QTOF-MS technology and further experimented that 14 compounds (one unknown compound and thirteen known compounds) could prevent and treat diseases caused by inflammation and oxidative stress. Liu et al (2023b) analyzed the components of Danshen decoction by UHPLC-Q-Orbitrap-MS technology, combined with network pharmacology, to elucidate that 35 compounds in its active components are potential pharmacodynamic materials for the treatment of cardiovascular diseases.…”

Section: Pharmacophoric Substance Discoverymentioning

confidence: 99%

Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine

et al. 2023

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Natural products derived from herbal medicine are a fruitful source of lead compounds because of their structural diversity and potent bioactivities. However, despite the success of active compounds derived from herbal medicine in drug discovery, some approaches cannot effectively elucidate the overall effect and action mechanism due to their multi-component complexity. Fortunately, mass spectrometry-based metabolomics has been recognized as an effective strategy for revealing the effect and discovering active components, detailed molecular mechanisms, and multiple targets of natural products. Rapid identification of lead compounds and isolation of active components from natural products would facilitate new drug development. In this context, mass spectrometry-based metabolomics has established an integrated pharmacology framework for the discovery of bioactivity-correlated constituents, target identification, and the action mechanism of herbal medicine and natural products. High-throughput functional metabolomics techniques could be used to identify natural product structure, biological activity, efficacy mechanisms, and their mode of action on biological processes, assisting bioactive lead discovery, quality control, and accelerating discovery of novel drugs. These techniques are increasingly being developed in the era of big data and use scientific language to clarify the detailed action mechanism of herbal medicine. In this paper, the analytical characteristics and application fields of several commonly used mass spectrometers are introduced, and the application of mass spectrometry in the metabolomics of traditional Chinese medicines in recent years and its active components as well as mechanism of action are also discussed.

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Chemical constituents from the stems and leaves of Amomum villosum Lour. and their anti-inflammatory and antioxidant activities

Cited by 11 publications

References 36 publications

Network medicine‐based analysis of the hepatoprotective effects of Amomum villosum Lour. on alcoholic liver disease in rats

Network medicine‐based analysis of the hepatoprotective effects of Amomum villosum Lour. on alcoholic liver disease in rats

Three New Labdane‐Type Diterpenoids from the Fruits of Amomum villosum and Their Anti‐Inflammatory Activities

Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine

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