Chemical constituents from the stem bark of Symplocos paniculata Thunb. with antimicrobial, analgesic and anti-inflammatory activities

Semwal, Ruchi Badoni; Semwal, Deepak Kumar; Singh, Randhir; Rawat, Mahiraj Singh

doi:10.1016/j.jep.2011.02.021

Cited by 12 publications

(9 citation statements)

References 26 publications

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“…Ethanolic extract of leaves showed activity against Entamoeba histolytica strain STA Ascardia galli 18,34 . S. paniculata plant has been used in bacterial infections 25 . The ethanolic extract of stem bark as well the compounds isolated from the fractional distillation showed anti-bacterial activity against Staphylococcus aureus, Bacillus subtilis, Pseudomonas auroginosa and Escherichia coli 25 .…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…S. paniculata plant has been used in bacterial infections 25 . The ethanolic extract of stem bark as well the compounds isolated from the fractional distillation showed anti-bacterial activity against Staphylococcus aureus, Bacillus subtilis, Pseudomonas auroginosa and Escherichia coli 25 . The compounds 3 and 5 isolated from stem bark showed a good antimicrobial agent and could be an alternate to the antibiotics in the treatment of infections caused by these microorganisms since most of them have developed resistance against the known antibiotics 50 .…”

Section: Antimicrobial Activitymentioning

confidence: 99%

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Symplocos paniculata Miq. - A Review

Chitra¹

2018

Int. J. Curr. Res. Biosci. Plant Biol.

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Historically plants have played an important role in medicine. Medicinal herbs are moving from fringe to mainstream use with a greater number of people seeking remedies. Through observation and experimentation, human beings have learnt that plants promote health. The use of these herbal remedies is not only cost effective but also safe and almost free from serious side effects. The genus Symplocos has been reviewed for its chemical constituents and biological activities including traditional importance of some common species. Symplocos paniculata is an evergreen Ayurvedic plant, with wide range of ethno medicinal uses including treatment for dysentery, bowel complaints, inflammations, snake bites, vaginal discharges and miscarriages. From various literatures the crude extracts of S. paniculata possess different kinds of biological functions studied by researchers through phytochemical, pharmacological and biochemical investigations. K e y w o r d sBiological activity Chemical constituents Medicinal plant Symplocos paniculata

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Section: Antimicrobial Activitymentioning

confidence: 99%

Section: Antimicrobial Activitymentioning

confidence: 99%

Symplocos paniculata Miq. - A Review

Chitra¹

2018

Int. J. Curr. Res. Biosci. Plant Biol.

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“…Cyclopropanic oleanane triterpenoids have infrequently been found in the plant kingdom. Up to now, about 15 of them have been identified in plants as polyhydroxylated acids (Kojima et al, 1988;Wang et al, 1988;Lin, 1998;Lee et al, 2008;Semwal et al, 2011;Djoumessi et al, 2012). According to previous reports, terpenoid cores have the ability to express anti-inflammatory activity (Recio et al, 1995;Yap and Lim, 2015).…”

Section: Introductionmentioning

confidence: 99%

ESI‐MS² and Anti‐inflammatory Studies of Cyclopropanic Triterpenes. UPLC‐ESI‐MS and MS² Search of Related Metabolites from Donella ubanguiensis

Sandjo

Nascimento

Silva

et al. 2016

Phytochemical Analysis

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“…The test samples were selected for investigating their analgesic activity in acetic acid induced writhing response in mice by following the method described earlier [14,15]. The mice were divided into eleven groups (I-XI) and placed in separate cages, each group consisting of 6 mice.…”

Section: Analgesic Activitymentioning

confidence: 99%

“…The anti-inflammatory activity was performed by following the modified methods described earlier [15,16]. The rats were divided into eleven groups of six animals each, named negative control (I), test group 1-9 (II-X) and positive control (XI).…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Analgesic and Anti-Inflammatory Activities of Extracts and Fatty Acids from Celtis australis L

Semwal¹,

Semwal²

2012

NPJ

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Context: Celtis australis L. (Ulmaceae) is a deciduous tree distributed to mountainous and sub-mountainous Himalaya. This plant has been used as traditional medicine in bone fracture, pimples, contusions, sprains and joint pains in India. Objectives: This is the first evaluation of C. australis extracts (bark and fruits) and fatty acids (fruits) for acute toxicity, analgesic, and anti-inflammatory activities. Materials and methods: The ethanol extracts of air dried stem bark and fruits were prepared at 30-50°C with 95% EtOH for 15h. The solvent was evaporated under reduced pressure and the powdery extracts so obtained were used for present study along with crude fatty acids obtained from column elution of n-C 6 H 12-CHCl 3 (6:4) of EtOAc fruit extract. Crude extracts and fatty acids were screened for analgesic and anti-inflammatory activities by oral administration of three different doses at 100, 250 and 500 mg/kg of each text sample on Swiss albino mice and Sprague-Dawley rats, respectively. Results: All doses (i.e. 100, 250, and 500 mg/kg) of test samples were found active when compared with negative control. Crude extracts and fatty acids at higher concentration (i.e. 500 mg/kg) showed analgesic activity protection of 59.28, 63.22, and 45.79%, respectively, whereas at the same concentration, the anti-inflammatory inhibition was 44.26, 45.90, and 42.62%, respectively. Paracetamol and phenylbutazone were used as positive controls for analgesic and antiinflammatory activities, respectively. Discussion and conclusion: Present study concludes that extracts (stem bark and fruits) and fatty acids (fruits) of C. australis have significant (p<0.05) analgesic and anti-inflammatory activities.

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Chemical constituents from the stem bark of Symplocos paniculata Thunb. with antimicrobial, analgesic and anti-inflammatory activities

Cited by 12 publications

References 26 publications

Symplocos paniculata Miq. - A Review

Symplocos paniculata Miq. - A Review

ESI‐MS² and Anti‐inflammatory Studies of Cyclopropanic Triterpenes. UPLC‐ESI‐MS and MS² Search of Related Metabolites from Donella ubanguiensis

Analgesic and Anti-Inflammatory Activities of Extracts and Fatty Acids from Celtis australis L

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Chemical constituents from the stem bark of Symplocos paniculata Thunb. with antimicrobial, analgesic and anti-inflammatory activities

Cited by 12 publications

References 26 publications

Symplocos paniculata Miq. - A Review

Symplocos paniculata Miq. - A Review

ESI‐MS2 and Anti‐inflammatory Studies of Cyclopropanic Triterpenes. UPLC‐ESI‐MS and MS2 Search of Related Metabolites from Donella ubanguiensis

Analgesic and Anti-Inflammatory Activities of Extracts and Fatty Acids from Celtis australis L

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Product

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ESI‐MS² and Anti‐inflammatory Studies of Cyclopropanic Triterpenes. UPLC‐ESI‐MS and MS² Search of Related Metabolites from Donella ubanguiensis