Chemical constituents from the fruits of Melia azedarach (Meliaceae)

Wang, Wenqi; Xia, Zhen‐Zhen; Tian, Zhenhua; Jiang, Haiqiang; Zhan, Yanfei; Liu, Changxin; Li, Chuanhou; Zhou, Honglei

doi:10.1016/j.bse.2020.104094

Cited by 11 publications

(7 citation statements)

References 24 publications

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“…Investigation of cytotoxic concentration and effective concentration of MAE in different cell lines and different viruses respectively is in our future study plan. Previously reported phytochemical studies on Melia azedarach have identified more than 300 chemical compounds, such as hydroxycoumarin [40], β-carotene, tocopherol and saqulene [41] lignans [40,42,43], steroids [44], flavonoids (quercetin), steroids, terpenoids [45,46]. Among them, relationship between antiviral effects and known or unknown component must be studied further.…”

Section: Discussionmentioning

confidence: 99%

Melia azedarach extract exhibits a broad spectrum of antiviral effect in vitro and in vivo

Nethmini¹,

Kim²,

Chathuranga³

et al. 2020

J Biomed Transl Res

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Melia azedarach is commonly used in traditional and folk medicine in Korea and China to treat a variety of diseases including diarrheal, diabetic, rheumatic, and hypertensive disease. The aim of this study was to determine the potential prophylactic and therapeutic effects of Melia azedarach against a broad spectrum of viruses in in vitro cell culture model and the protective effect against different influenza A subtypes in BALB/c mice model. An effective dose of pre-treatment, co-treatment, and post-treatment of Melia azedarach significantly reduced the replication of coxsackievirus, herpes simplex virus, influenza A virus, enterovirus, and bovine rhinovirus in both epithelial and macrophage cell lines. Melia azedarach treatment remarkably promoted the phosphorylation of the key molecules associated with the type-1 interferon and NF-κB signaling pathways. Furthermore, it induced the secretion of type-1 interferon and pro-inflammatory cytokines and the subsequent stimulation of the antiviral state in both epithelial and macrophage cells. Interestingly, oral inoculation of an effective dose of herb extract significantly improved viral clearance in the lungs of BALB/c mice, thus exhibiting protection against several subtypes of influenza A virus. Together with our results indicate that an extracts of Melia azedarach and its components could exhibit a potential natural source of an antiviral drug candidate for a broad spectrum of viruses in animal and humans.

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Section: Discussionmentioning

confidence: 99%

Melia azedarach extract exhibits a broad spectrum of antiviral effect in vitro and in vivo

Nethmini¹,

Kim²,

Chathuranga³

et al. 2020

J Biomed Transl Res

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“…Lepidotrichilin A ( 109) is C21 carbonyl analog of Dysorone D. Compound ( 112) is C3 tigloyl analog of previously reported Sapelin D 98 . The tigloyl group at C3 in compound (112) is displaced by the benzoyl group in 3α-benzoate triterpenoid A (113). Dysohainanin E/Mesendanin U ( 115) is C7 acetyl analog of compound (114).…”

Section: Apoprotolimonoid/apotirucallanetriterpenoidmentioning

confidence: 99%

Chemistry and Biology of Novel Meliaceae Limonoids

Mulani

Nandikol

Thulasiram

2022

Preprint

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Nature has bestowed us with abundant bioactive/drug molecules for various uses in our everyday life. One such group of plant specialized molecules is limonoids, which are structurally characterized as 4,4,8-trimethyl-17-furanyl steroidal skeleton. Limonoids are well known for their various biological activities such as potent anti-feedent, anti-cancer, anti-inflammatory, insecticidal, anti-diabetic, anti-viral, anti-microbial etc. These tetranortriterpenes are highly oxygenated and structurally diversified molecules majorly found in Meliaceae and Rutaceae and less frequently in the Cneoraceae families in the plant kingdom. Many of these plants have been used in traditional medicine from ages. One of the well-known limonoid, azadirachtin A is highly valued and widely popular for its outstanding insecticidal properties. Till date, nearly 2500 limonoids with over 35 unique carbon frameworks have been observed. In recent times, these molecules have dig a great interest among researchers due to their myriad biological properties. With the advancement of analytical techniques, the limonoid research is aced to explore more different molecules from their sources. In our review we cover all the Meliaceous limonoids isolated during July 2010 to Dec 2020. We found over 1502 new limonoids, which are reported from various Meliaceae plants after Jun 2010. We have classified them based on their skeletal structure rearrangements and functional groups into various classes such as protolimonoids, Apoprotolionoid, Azadirone, Vilasinin, Cedrelone, Havanensin, Trichilin, Nimbin, Salannin, Azadirachtin, Nimbolidin, Nimbolinin, Obacunol, Evodulone, Trijugin, Cipadesin, Andirobin, Mexicanolide, Phragmalin, Khayanolide, Preieurianin, Aphanamixoid, Nor Limonoid and N-containing derivatives. Further we have discussed their biological activities in detail.

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“…M. azedarach that is also known as Chinaberry is a tree native to Asia and Australia (Neycee et al, 2012). The studies on the fruit of M. azedarach have stated more than 300 compounds, including polyphenols, limonoids, steroids, terpenoids, anthraquinones, and lignans (Wang et al, 2020). Recently, several polyphenolic compounds have been identified in the fruit of the plant (M'rabet et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Ultrasound‐assisted extraction optimization of polyphenols, flavonoids, and antioxidant compounds from fruit of Melia azedarach using a glycerol‐based green deep eutectic solvent

Jamshed

Ahmed

Aydar

2022

Food Processing Preservation

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Plants (herbs, shrubs, and trees) are a major source of bioactive and industrially important chemical compounds such as polyphenols including flavonoids having medicinal importance (Efferth & Koch, 2011). The natural products generally have complex structures with many functional groups and several chiral centers.Consequently, it is often difficult to synthesize these substances in the laboratory. To synthesize such compounds is also a costly affair as often the synthesis involves many steps each with its own problems. Due to these and other difficulties, it is generally more viable to extract the desired natural products from plants having good amounts of these substances. In the last decades, a wide research work has been done on process and techniques used for extraction. Efficacy, cost, and environment-responsiveness are some of the main desirable attributes that a viable extraction process or technique should have (Aydar, 2019).The plant Melia azedarach Linn (family: Meliaceae) is widely distributed in tropical and subtropical regions of Asia. The fruit of the plant is a drupe, marble-sized, having four to five seeds grooved in the shell. The genus Melia includes around 20 species. M. azedarach

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Chemical constituents from the fruits of Melia azedarach (Meliaceae)

Cited by 11 publications

References 24 publications

Melia azedarach extract exhibits a broad spectrum of antiviral effect in vitro and in vivo

Melia azedarach extract exhibits a broad spectrum of antiviral effect in vitro and in vivo

Chemistry and Biology of Novel Meliaceae Limonoids

Ultrasound‐assisted extraction optimization of polyphenols, flavonoids, and antioxidant compounds from fruit of Melia azedarach using a glycerol‐based green deep eutectic solvent

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