Melia azedarach extract exhibits a broad spectrum of
                    antiviral effect in vitro and in
                    vivo

Nethmini, N. A. Nadeeka; Kim, Myun Soo; Chathuranga, Kiramage; Yeul, Jin; Kim, Hongik; Lee, Jong-Soo

doi:10.12729/jbtr.2020.21.3.125

Cited by 7 publications

(3 citation statements)

References 38 publications

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“…The tree Melia azedarach (Family: Meliaceae) is locally recognized as a bakain or drek (Hindi), Persian lilac or China tree (English), and Fleurs lilas (French). In South America, it is generally known as “paraiso” or paradise, and in the US as the Indian lilac or white cedar [ 16 ]. The whole plant or its specific parts (leaves, stems, and roots) are known to have medicinal properties and an extended history of use by indigenous and tribal people in India.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Melia azedarach extract-loaded poly (vinyl alcohol)/pectin hydrogel for burn wound healing

2022

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Background In this study, a hydrogel comprising poly (vinyl alcohol)/pectin (PVA/PET) was prepared by the addition of Melia azedarach extract for epithelial restoration. M. azedarach extract (MAE) contains volatile organic plant-derived compounds with antimicrobial properties. MAE has a variety of physiological properties, including antimicrobial, insecticidal, and anti-inflammatory activity. This study aimed to investigate whether MAE-loaded PVA/PET hydrogels have protective effects against burn wound healing. Methods and findings To mix M. azedarach with the gel, nanoparticles containing M. azedarach were prepared using chitosan/maltodextrin as the wall material. A PVA/PET hydrogel containing M. azedarach was developed and its applicability as a wound dressing was evaluated. In the in vitro scratch assay, MAE treatment showed a scratch recovery-promoting effect comparable to that of the positive control TGF-β1. The MAE-PVA/PET hydrogel was found to be non-toxic, and the antibacterial activity of the hydrogel was excellent against both gram-positive and gram-negative bacteria. Furthermore, as the formulated hydrogel demonstrated strong antimicrobial activity, its wound-healing efficacy was investigated in vivo using a rat model. Conclusion MAE was found to be effective against burn wounds and to have antimicrobial activity in vitro and in vivo.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Melia azedarach extract-loaded poly (vinyl alcohol)/pectin hydrogel for burn wound healing

2022

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“…In this study, we explored the in vitro viral inhibitory activity of M. azedarach L. leaves extract against SARS-CoV-2 which is so far not studied. Nethmini et al found that M. azedarach L. could turn off the replication of herpes simplex virus, coxsackie virus, enterovirus, influenza A virus, and bovine rhinovirus in both epithelial and macrophage cell lines [46].…”

Section: Plos Onementioning

confidence: 99%

Bioactive Azadirachta indica and Melia azedarach leaves extracts with anti-SARS-CoV-2 and antibacterial activities

et al. 2023

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The leaves of Azadirachta indica L. and Melia azedarach L., belonging to Meliaceae family, have been shown to have medicinal benefits and are extensively employed in traditional folk medicine. Herein, HPLC analysis of the ethyl acetate fraction of the total methanolic extract emphasized the enrichment of both A. indica L., and M. azedarach L. leaves extracts with phenolic and flavonoids composites, respectively. Besides, 4 limonoids and 2 flavonoids were isolated using column chromatography. By assessing the in vitro antiviral activities of both total leaves extracts against Severe Acute Respiratory Syndrome Corona virus 2 (SARS-CoV-2), it was found that A. indica L. and M. azedarach L. have robust anti-SARS-CoV-2 activities at low half-maximal inhibitory concentrations (IC50) of 8.451 and 6.922 μg/mL, respectively. Due to the high safety of A. indica L. and M. azedarach L. extracts with half-maximal cytotoxic concentrations (CC50) of 446.2 and 351.4 μg/ml, respectively, both displayed extraordinary selectivity indices (SI>50). A. indica L. and M. azedarach L. leaves extracts could induce antibacterial activities against both Gram-negative and positive bacterial strains. The minimal inhibitory concentrations of A. indica L. and M. azedarach L. leaves extracts varied from 25 to 100 mg/mL within 30 min contact time towards the tested bacteria. Our findings confirm the broad-spectrum medicinal value of A. indica L. and M. azedarach L. leaves extracts. Finally, additional in vivo investigations are highly recommended to confirm the anti-COVID-19 and antimicrobial activities of both plant extracts.

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“…Melia species can grow rapidly, and they are widely grown in China, especially M. azedarach , because of the mechanical properties of their wood, which makes them resistant to insects, pathogens, and corrosion [ 1 ]. Melia species are also often used as medicinal plants for the treatment of various diseases, including diarrhea, diabetes, rheumatic diseases, and hypertension [ 5 ]. Several studies have examined the chemical constituents (e.g., limonoids and triterpenoids) extracted from the fruits, stem bark, and leaves of M. azedarach and M. toosendan [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Climate-Driven Adaptive Differentiation in Melia azedarach: Evidence from a Common Garden Experiment

Liao

Que

et al. 2022

Genes

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Studies of local adaptation in populations of chinaberry (Melia azedarach L.) are important for clarifying patterns in the population differentiation of this species across its natural range. M. azedarach is an economically important timber species, and its phenotype is highly variable across its range in China. Here, we collected M. azedarach seeds from 31 populations across its range and conducted a common garden experiment. We studied patterns of genetic differentiation among populations using molecular markers (simple sequence repeats) and data on phenotypic variation in six traits collected over five years. Our sampled populations could be subdivided into two groups based on genetic analyses, as well as patterns of isolation by distance and isolation by environment. Significant differentiation in growth traits was observed among provenances and families within provenances. Geographic distance was significantly correlated with the quantitative genetic differentiation (QST) in height (HEIT) and crown breadth. Climate factors were significantly correlated with the QST for each trait. A total of 23 climatic factors were examined. There was a significant effect of temperature on all traits, and minimum relative humidity had a significant effect on the survival rate over four years. By comparing the neutral genetic differentiation (FST) with the QST, the mode of selection acting on survival rate varied, whereas HEIT and the straightness of the main trunk were subject to the same mode of selection. The variation in survival rate was consistent with the variation in genetic differentiation among populations, which was indicative of local adaptation. Overall, our findings provide new insights into the responses of the phenological traits of M. azedarach to changes in the climate conditions of China.

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Melia azedarach extract exhibits a broad spectrum of antiviral effect in vitro and in vivo

Cited by 7 publications

References 38 publications

Evaluation of Melia azedarach extract-loaded poly (vinyl alcohol)/pectin hydrogel for burn wound healing

Evaluation of Melia azedarach extract-loaded poly (vinyl alcohol)/pectin hydrogel for burn wound healing

Bioactive Azadirachta indica and Melia azedarach leaves extracts with anti-SARS-CoV-2 and antibacterial activities

Climate-Driven Adaptive Differentiation in Melia azedarach: Evidence from a Common Garden Experiment

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