Chemical Constituents from the Barks of Swietenia macrophylla

Tian, Liwen; Xi-feng, Teng; Cheng, Zhong; Xie, Yang

doi:10.21127/yaoyigc20150002

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…20 This data is in agreement with previous works showing the presence of phragmalin limonoids in species collected in Asia. [21][22][23][24] According to Moghadamtousi et al, 11 there seems not to be much variety in the class of compounds in S. macrophylla, since, among the 93 compounds listed in a phytochemical review, 77 of them belong to the limonoid class, among which 38 are phragmalin type.…”

Section: Introductionmentioning

confidence: 99%

Phragmalin Limonoids from Swietenia macrophylla and Their Antifeedant Assay against Mahogany Predator

Pamplona¹,

Arruda²,

Castro³

et al. 2018

J. Braz. Chem. Soc.

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The purification of the hexanic extract from the leaves of a native variety of mahogany collected in Santarém (Pará, Brazil) afforded eight new phragmalin limonoids along with eight known compounds. This variety, according to field observations, should be considered resistant against the specialist insect Hypsipyla grandella, that attacks the terminal shoots only of juvenile mahogany and not of matured ones. After observing that four phragmalin limonoids were present just in mature leaves, we carried out two bioassays, one of them using a fraction from hexanic extract of mature leaves and another using a mix of four limonoids. The results of the bioassay using the isolated limonoids showed a direct effect on the larvae of H. grandella, suggesting that these limonoids act as inhibitors of larvae growth. This should be the reason why larvae choose the young leaves for their development.

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Section: Introductionmentioning

confidence: 99%

Phragmalin Limonoids from Swietenia macrophylla and Their Antifeedant Assay against Mahogany Predator

Pamplona¹,

Arruda²,

Castro³

et al. 2018

J. Braz. Chem. Soc.

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show abstract

“…The drug discovery from natural products possess several advantages such as timeliness, faster and better methods for bioassay screening, and compound isolation. [30] Currently, naturally occurring phenols with antithrombotic activities have been reported in the recent literature or patents, which would provide many clues to find the novel agents. This progress holds a considerable promise to the development of alternative, highly effective and secure therapeutics agents and ultimately the eradication of thrombosis disease.…”

Section: Introductionmentioning

confidence: 99%

Natural Products Phenols as Novel Antithrombotic Agents

Zhou¹,

Guo²

2018

Med. Res.

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“…Thus, substances that can accelerate its activation has promising applications for the treatment of thrombosis or arteriosclerosis [7]. Natural products with various structures offer more opportunities to discover lead compounds or drugs [8,9]. An isoindolone derivative, Fungi fibrinolytic compound (R)-2,5-bis((2R,3R)-2-((E)-4,8-dimethylnona-3,7-dien-1-yl)-3,5-dihydroxy-2-methyl-7-oxo-3,4,7,9-tetr ahydropyrano [2,3-e]isoindol-8(2H)-yl)pentanoic acid (FGFC1, Fungi fibrinolytic compound 1, Figure 2), was isolated from a rare marine microorganism strain Stachybotrys longispora FG216.…”

Section: Introductionmentioning

confidence: 99%

A Marine Fibrinolytic Compound FGFC1 Stimulating Enzymatic Kinetic Parameters of a Reciprocal Activation System Based on a Single Chain Urokinase-Type Plasminogen Activator and Plasminogen

Guo¹,

Duan²,

Hong³

et al. 2017

Preprint

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A marine fibrinolytic compound FGFC1 enhancing fibrinolysis was obtained involving enzymatic kinetic parameters of a reciprocal activation system with a single chain urokinase type plasminogen activator and plasminogen. FGFC1, a kind of bisindole alkaloid from a metabolite of the rare marine fungi Starchbotrys longispora FG216, modulated enzymatic kinetic parameters including the fibrinolytic reaction rate and fibrin degradation characteristics. The enzymatic kinetics of fibrinolysis was described based on the enzymatic reaction of a chromogenic-substrate associated with p-nitroaniline (p-NA). While the single chain urokinase-type plasminogen activator (pro-uPA) activated plasminogen, kcat and kcat/Km increased significantly with an increase of FGFC1 concentration. Moreover, kcat and kcat/Km exhibited 26.5-fold and 22.8-fold enhanced activity at the concentration of 40 μg·mL −1 of FGFC1, respectively. The results suggested that FGFC1 significantly improved the maximum catalytic efficiency and the total catalytic activity of fibrinolysis base on the reciprocal activation of pro-uPA and plasminogen. Km increased with increasing FGFC1 concentration, which indicated that FGFC1 slightly decreased the affinity activity of the pro-uPA and plasminogen versus the enzyme substrate. The marine bisindole alkaloid FGFC1 enhanced fibrinolysis, which was taken on enzymatic kinetic characteristics.

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Chemical Constituents from the Barks of Swietenia macrophylla

Cited by 6 publications

References 12 publications

Phragmalin Limonoids from Swietenia macrophylla and Their Antifeedant Assay against Mahogany Predator

Phragmalin Limonoids from Swietenia macrophylla and Their Antifeedant Assay against Mahogany Predator

Natural Products Phenols as Novel Antithrombotic Agents

A Marine Fibrinolytic Compound FGFC1 Stimulating Enzymatic Kinetic Parameters of a Reciprocal Activation System Based on a Single Chain Urokinase-Type Plasminogen Activator and Plasminogen

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