“…Thus, substances that can accelerate its activation has promising applications for the treatment of thrombosis or arteriosclerosis [7]. Natural products with various structures offer more opportunities to discover lead compounds or drugs [8,9]. An isoindolone derivative, Fungi fibrinolytic compound (R)-2,5-bis((2R,3R)-2-((E)-4,8-dimethylnona-3,7-dien-1-yl)-3,5-dihydroxy-2-methyl-7-oxo-3,4,7,9-tetr ahydropyrano [2,3-e]isoindol-8(2H)-yl)pentanoic acid (FGFC1, Fungi fibrinolytic compound 1, Figure 2), was isolated from a rare marine microorganism strain Stachybotrys longispora FG216.…”