Chemical Constituents from Swartzia oblata and Antitumoral Activity Evaluation

Abstract

First phytochemical study from Swartzia oblata resulted of the hexane fraction from wood, the isolation of a mixture of macrolides Lasiodiplodin (1) and O-methyl-lasiodiplodin (2) isolated for the first time in the genus and the mixture of phytosterols campesterol (3) and sitosterol (4). The structures were established after analysis of 1 H and 13 C NMR (1D and 2D), MS and comparison with literature data. The study of this fraction was oriented after phytochemical prospecting and analysis by 1 H NMR of leaf and wood fractions besides the analysis of the antitumor activity of fractions against U937 histiocytic lymphoma cells. The results indicated the hexane fractions of leaves (EC50 = 276 ± 1.2 mg / mL) and wood (EC50 = 230 ± 1.1 mg / mL) as the most active.