Chemical constituents from Sonneratia ovata Backer and their in vitro cytotoxicity and acetylcholinesterase inhibitory activities

Nguyen, Thi-Hoai-Thu; Pham, Huu-Viet-Thong; Pham, Nguyen-Kim-Tuyen; Quach, Ngo-Diem-Phuong; Pudhom, Khanitha; Hansen, Poul Erik; Nguyen, Kim‐Phi‐Phung

doi:10.1016/j.bmcl.2015.04.017

Cited by 34 publications

(13 citation statements)

References 23 publications

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“…One of the compounds, namely Rhodolatouchol (Fig. 15A) suppressed AChE activity and the growth of NCI-H460 cells in cell culture models (Nguyen, et al, 2015). 3-alkyl pyridium polymers (poly-APS), a class of compounds isolated from marine sponge extracts displayed potent AChE-inhibitory activity (Zovko, Specici, & Turk, 2009).…”

Section: Cholinesterases (Ches)mentioning

confidence: 99%

Acetylcholine signaling system in progression of lung cancers

Friedman

Richbart

Merritt

et al. 2019

Pharmacology & Therapeutics

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The neurotransmitter acetylcholine (ACh) acts as an autocrine growth factor for human lung cancer. Several lines of evidence show that lung cancer cells express all of the proteins required for the uptake of choline (choline transporter 1, choline transporter-like proteins) synthesis of ACh (choline acetyltransferase, carnitine acetyltransferase), transport of ACh (vesicular acetylcholine transport, OCTs, OCTNs) and degradation of ACh (acetylcholinesterase, butyrylcholinesterase). The released ACh binds back to nicotinic (nAChRs) and muscarinic receptors on lung cancer cells to accelerate their proliferation, migration and invasion. Out of all components of the cholinergic pathway, the nAChR-signaling has been studied the most intensely. The reason for this trend is due to genome-wide data studies showing that nicotinic receptor subtypes are involved in lung cancer risk, the relationship between cigarette smoke and lung cancer risk as well as the rising popularity of electronic cigarettes considered by many as a "safe" alternative to smoking. There are a small number of review articles which review the contribution of the other cholinergic proteins in the pathophysiology of lung cancer. The primary objective of this review article is to discuss the function of the acetylcholine-signaling proteins in the progression of lung cancer. The investigation of the role of cholinergic network in lung cancer will pave the way to novel molecular targets and drugs in this lethal malignancy.

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Section: Cholinesterases (Ches)mentioning

confidence: 99%

Acetylcholine signaling system in progression of lung cancers

Friedman

Richbart

Merritt

et al. 2019

Pharmacology & Therapeutics

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“…The cytotoxicity of all compounds against human tumor cell lines of HL-60, HeLa, HCT15, A459, HepG2, PC-3, CNE-2 and BCG-823 was assayed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method in vitro. The assay protocol was conducted by previous published paper [ 24 , 39 ]. The tested compounds 1 – 10 were dissolved in DMSO and adjusted to the final concentrations from 1.0 μM to 300 μM by diluting with the growth medium.…”

Section: Methodsmentioning

confidence: 99%

The Antitumor Constituents from Hedyotis Diffusa Willd

et al. 2017

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As a TCM, Hedyotis diffusa Willd. has been using to treat malignant tumors, and many studies also showed that the extracts from Hedyotis diffusa Willd. possessed evident antitumor activities. Therefore, we carried out chemical study on Hedyotis diffusa Willd. and investigated the cytotoxicity of the obtained compounds on a panel of eight tumor cell lines. As a result, four new compounds were isolated from Hedyotis diffusa Willd., including three iridoid glycosides of Shecaoiridoidside A–C (1–3) and a cerebroside of shecaocerenoside A (4). Also, six known iridoid compounds (5–10) were also obtained. The cytotoxicity of all compounds against human tumor cell lines of HL-60, HeLa, HCT15, A459, HepG2, PC-3, CNE-2, and BCG-823 were also evaluated in vitro. New compound 3 exhibited evident cytotoxicity to all tumor cell lines except the Hela, and the IC50 values are from 9.6 µM to 62.2 µM, while new compound 4 showed moderate cytotoxicity to all the cell lines, and the IC50 values are from 33.6 µM to 89.3 µM. By contrast, new compound 1 and known compound 9 showed moderate cytotoxicity to HCT15, A459, and HepG2 selectively. Known compound 7 also exhibited moderate cytotoxicity to HCT15 and A459 selectively.

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“…Berbagai bagian tumbuhan Sonneratia sp, seperti buah, kulit kayu, dan daun telah dimanfaatkan oleh masyarakat dalam pengobatan tradisional seperti untuk pengobatan asma, untuk menurunkan panas, pengobatan ambeien, keseleo, bisul, hepatitis, dan menghentikan pendarahan (Nguyen et al, 2015). Soeroyo et al, (1989) melaporkan bubur buah pedada digunakan untuk mengatasi kejang-kejang atau salah urat, ekstrak air buah untuk mengobati batuk, dan air buahnya yang telah difermentasi dipakai untuk menghentikan pendarahan.…”

Section: Pendahuluanunclassified

ANALISIS PROKSIMAT DAN FITOKIMIA BUAH PEDADA (Sonneratia ovata Back.)

Astuti

Wulandari

Rosyidah

et al. 2021

JSTK

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Analisis proksimat dan fitokimia buah pedada (Sonneratia ovata Back.) telah dilakukan. Analisis proksimat meliputi penetapan kadar air, abu, protein, lemak dan karbohidrat. Analisis fitokimia meliputi skrining fitokimia dan penetapan kadar saponin dan flavonoid. Hasil penelitian menunjukkan buah pedada memiliki kadar air 64,28%, abu 1,04%, lemak 1,80%, protein 9,33%, dan karbohidrat 2,19%. Skrining fitokimia menunjukkan buah pedada mengandung flavonoid, saponin, karotenoid dan steroid. Kadar saponin sebesar 0,99% dan kadar flavonoid sebesar 23,077 mgEQ/g.

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Chemical constituents from Sonneratia ovata Backer and their in vitro cytotoxicity and acetylcholinesterase inhibitory activities

Cited by 34 publications

References 23 publications

Acetylcholine signaling system in progression of lung cancers

Acetylcholine signaling system in progression of lung cancers

The Antitumor Constituents from Hedyotis Diffusa Willd

ANALISIS PROKSIMAT DAN FITOKIMIA BUAH PEDADA (Sonneratia ovata Back.)

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