Chemical Constituents and Biological Properties of the Marine Soft Coral &lt;em&gt;Nephthea&lt;/em&gt;: A Review (Part 2)

Amir, F; Koay, YC; Yam, Wan Sinn

doi:10.4314/tjpr.v11i3.20

Cited by 9 publications

(8 citation statements)

References 14 publications

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“…Similarly, the mass ion peak at m/z 240.172 for the predicted molecular formula C 14 H 24 O 3 , was dereplicated as the sesquiterpenes; chabranol (19), which was formerly characterized from Nephthea chabrolii [23]. Moreover, the mass ion peak at m/z 250.193 in agreement with the molecular formula C 16 H 26 O 2 was dereplicated as the sesquiterpenes; Methoxycolorenone (20) and/or 2-deoxy-7-O-methyllemnacarnol (21), the former was previously reported from Nephthea chabrolii [27], while the other was previously reported from Nephthea sp. [28].…”

Section: Metabolomic Analysismentioning

confidence: 81%

“…Likewise, the mass ion peak at m/z 204.187 for the predicted molecular formula C 15 H 24 was also dereplicated as the sesquiterpene; 4,15-dihydro guaian-6,10-diene (2), which was previously obtained from Nephthea chabrolii [19]. Additionally, the mass ion peak at m/z 220.183 in accordance with the molecular formula C 15 H 24 O, was dereplicated as eudesma-4,7(11)-diene-8β-ol (3) and/or guaianediol (4) and/or 1S,4R,5S-guia-6,9-dien-4-ol (5) and/or 3,4-epoxyguaia-10(12)-ene (6) and/or guaian-4,6-dien-10α-ol (7) and/or 8β-hydroxyprespatane (8) and/or capillosanol (9), all of these sesquiterpenes were previously obtained from Nephthea chabrolii [20] [21] [19], except sesquiterpenes (6) and (8) were obtained from Nephthea sp. and Nephthea erecta respectively [22] [23].…”

Section: Metabolomic Analysismentioning

confidence: 99%

See 1 more Smart Citation

Anti-Trypanosomal Potential of The Red Sea Soft Coral Nephthea Mollis Supported by Metabolomic Profiling and Molecular Docking Studies

Allam

Mostafa

Abdelmohsen

et al. 2021

Preprint

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The total ethanol extract and its derived ethyl acetate fraction of the soft coral Nephthea mollis displayed remarkable in-vitro anti-trypanosomal potential against Trypanosoma brucei with IC50 value of 6.4 and 3.7 (µg/ml, 72 h respectively. Consequently, the total ethanol extract was subjected to LC-HR-ESI-MS metabolomic profiling to discover the constituents that possibly underlie their bioactivities. Therefore, thirty-three secondary metabolites were characterized, among them, sesquiterpenes and diterpenes were found to prevail. In silico modeling was carried out on the dereplicated compounds to provide an insight into their anti-trypanosomal mechanism of action with docking study on ornithine decarboxylase (ORD) which illustrated that five of the dereplicated compounds (‎2-deoxy-12-ethoxy-7-O-methyl lemnacarnol, Nephthenol, ‎4α-O-acetyl-selin-11-en, Eudesma-4,7(11)-diene-8β-ol, and Chabrolidione A) have the highest affinity to the ornithine decarboxylase enzyme. These results highlight the valuable chemical profile of Nephthea mollis as a lead source for anti-trypanosomal natural products.

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Section: Metabolomic Analysismentioning

confidence: 81%

Section: Metabolomic Analysismentioning

confidence: 99%

Anti-Trypanosomal Potential of The Red Sea Soft Coral Nephthea Mollis Supported by Metabolomic Profiling and Molecular Docking Studies

Allam

Mostafa

Abdelmohsen

et al. 2021

Preprint

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“…The chemical and structural diversity of soft corals sterols and triterpenoids is well known and has been documented in several review articles in the literature [128,130,[257][258][259][260][261]. PASS analysis shows that the steroids in Figure 21 synthesized by soft corals are indeed of interest due to their high anticholesterol activity.…”

Section: Comparison Of Biological Activities Of Soft Coral Steroidsmentioning

confidence: 92%

In Silico Prediction of Steroids and Triterpenoids as Potential Regulators of Lipid Metabolism

Dembitsky

2021

Marine Drugs

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This review focuses on a rare group of steroids and triterpenoids that share common properties as regulators of lipid metabolism. This group of compounds is divided by the type of chemical structure, and they represent: aromatic steroids, steroid phosphate esters, highly oxygenated steroids such as steroid endoperoxides and hydroperoxides, α,β-epoxy steroids, and secosteroids. In addition, subgroups of carbon-bridged steroids, neo steroids, miscellaneous steroids, as well as synthetic steroids containing heteroatoms S (epithio steroids), Se (selena steroids), Te (tellura steroids), and At (astatosteroids) were presented. Natural steroids and triterpenoids have been found and identified from various sources such as marine sponges, soft corals, starfish, and other marine invertebrates. In addition, this group of rare lipids is found in fungi, fungal endophytes, and plants. The pharmacological profile of the presented steroids and triterpenoids was determined using the well-known computer program PASS, which is currently available online for all interested scientists and pharmacologists and is currently used by research teams from more than 130 countries of the world. Our attention has been focused on the biological activities of steroids and triterpenoids associated with the regulation of cholesterol metabolism and related processes such as anti-hyperlipoproteinemic activity, as well as the treatment of atherosclerosis, lipoprotein disorders, or inhibitors of cholesterol synthesis. In addition, individual steroids and triterpenoids were identified that demonstrated rare or unique biological activities such as treating neurodegenerative diseases, Alzheimer’s, and Parkinson’s diseases with a high degree of certainty over 95 percent. For individual steroids or triterpenoids or a group of compounds, 3D drawings of their predicted biological activities are presented.

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“…Cnidarians are the second largest source (aer sponges) of new marine natural products reported each year, with a predominance of terpenoid metabolites [80][81][82] and are also well represented in the deep sea. 83,84 Anthozoans are the most abundant class of cnidarians with over 6500 species known. 83,84 Anthozoans are the most abundant class of cnidarians with over 6500 species known.…”

Section: Cnidariamentioning

confidence: 99%

Recent advances in deep-sea natural products

2014

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Covering: 2009 to 2013. This review covers the 188 novel marine natural products described since 2008, from deep-water (50->5000 m) marine fauna including bryozoa, chordata, cnidaria, echinodermata, microorganisms, mollusca and porifera. The structures of the new compounds and details of the source organism, depth of collection and country of origin are presented, along with any relevant biological activities of the metabolites. Where reported, synthetic studies on the deep-sea natural products have also been included. Most strikingly, 75% of the compounds were reported to possess bioactivity, with almost half exhibiting low micromolar cytotoxicity towards a range of human cancer cell lines, along with a significant increase in the number of microbial deep-sea natural products reported.

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Chemical Constituents and Biological Properties of the Marine Soft Coral <em>Nephthea</em>: A Review (Part 2)

Abstract: Abstract

Cited by 9 publications

References 14 publications

Anti-Trypanosomal Potential of The Red Sea Soft Coral Nephthea Mollis Supported by Metabolomic Profiling and Molecular Docking Studies

Anti-Trypanosomal Potential of The Red Sea Soft Coral Nephthea Mollis Supported by Metabolomic Profiling and Molecular Docking Studies

In Silico Prediction of Steroids and Triterpenoids as Potential Regulators of Lipid Metabolism

Recent advances in deep-sea natural products

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