Recent advances in deep-sea natural products

Skropeta, Danielle; Wei, Liangqian

doi:10.1039/c3np70118b

Cited by 186 publications

(153 citation statements)

References 215 publications

(392 reference statements)

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“…The author would also like to thank Danielle Skropeta for deep-sea natural products data in Fig.1 (Skropeta, 2008, Skropeta andWei, 2014). This paper is based on a presentation by the author to the 14th Deep-Sea Biology Symposium (Aveiro, 01 September 2015), the author gratefully acknowledges funding support from the University of Wollongong Global Challenges Program to attend at this conference.…”

Section: Resultsmentioning

confidence: 99%

“…1). Furthermore, 75% of the novel deep-sea natural products described between 2009 and 2013 were found to be biologically active with almost half showing anti-cancer potential (Skropeta and Wei, 2014). The deep-sea is recognised as a significant source of genetic resources.…”

Section: Lack Of Definition Of Mgr and Unclear Legal Status In Abnjmentioning

confidence: 99%

“…For example, enzymes from heat tolerant hyperthermophiles have been used in the production of DNA polymerase (Atomi, 2005). Deep-sea genetic resources research is still at a relatively early stage in comparison to other genetic resources research, but is recognised as a potential growth area (EU, 2014, Martins et al, 2014, Rogers et al, 2015, Skropeta and Wei, 2014. Areas for further deep-sea genetic resources research that have been identified, include organisms adapted to high pressure, oxygen minimum zones, chemosynthetic environments and pelagic environments (Robison, 2009, Rogers et al, 2015.…”

Section: Lack Of Definition Of Mgr and Unclear Legal Status In Abnjmentioning

confidence: 99%

“…Of the more than 1 million novel natural products described overall (Martins et al, 2014), more than 30,000 derive from marine origin and 600 derive from depths exceeding 50m (Skropeta and Wei, 2014). The majority of deep-sea natural products described originate in areas within national jurisdiction, with almost one quarter emanating from Australian waters (Skropeta and Wei, 2014). Few of the described deep-sea natural products originate from ABNJ.…”

Section: Lack Of Definition Of Mgr and Unclear Legal Status In Abnjmentioning

confidence: 99%

“…The rich biological diversity of the deep-sea is a source of vast genetic and biochemical diversity with a range of potential applications, from advancing scientific knowledge to developing new commercial products (Martins et al, 2014, Skropeta andWei, 2014). These so-called "marine genetic resources" 2 (MGR) are one of the ecosystem services provided by the deep-sea (Armstrong et al, 2012.…”

Section: Introductionmentioning

confidence: 99%

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Deep-sea genetic resources: New frontiers for science and stewardship in areas beyond national jurisdiction

Harden‐Davies

2017

Deep Sea Research Part II: Topical Studies in Oceanography

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The deep-sea is a large source of marine genetic resources (MGR), which have many potential uses and are a growing area of research. Much of the deep-sea lies in areas beyond national jurisdiction (ABNJ), including 65% of the global ocean. MGR in ABNJ occupy a significant gap in the international legal framework. Access and benefit sharing of MGR is a key issue in the development of a new international legally-binding instrument under the United Nations Convention on the Law of the Sea (UNCLOS) for the conservation and sustainable use of marine biological diversity in ABNJ. This paper examines how this is relevant to deep-sea scientific research and identifies emerging challenges and opportunities. There is no internationally agreed definition of MGR, however, deep-sea genetic resources could incorporate any biological material including genes, proteins and natural products. Deep-sea scientific research is the key actor accessing MGR in ABNJ and sharing benefits such as data, samples and knowledge. UNCLOS provides the international legal framework for marine scientific research, international science cooperation, capacity building and marine technology transfer. Enhanced implementation could support access and benefit sharing of MGR in ABNJ. Deep-sea scientific researchers could play an important role in informing practical new governance solutions for access and benefit sharing of MGR that promote scientific research in ABNJ and support deep-sea stewardship. Advancing knowledge of deep-sea biodiversity in ABNJ, enhancing open-access to data and samples, standardisation and international marine science cooperation are significant potential opportunity areas. There is no internationally agreed definition of MGR, however, deep-sea genetic resources could incorporate any biological material including genes, proteins and natural products.Deep-sea scientific research is the key actor accessing MGR in ABNJ and sharing benefits such as data, samples and knowledge. UNCLOS provides the international legal framework for marine scientific research, international science cooperation, capacity building and marine technology transfer. Enhanced implementation could support access and benefit sharing of MGR in ABNJ. Deep-sea scientific researchers could play an important role in informing practical new governance solutions for access and benefit sharing of MGR that promote scientific research in ABNJ and support deep-sea stewardship. Advancing knowledge of 2 deep-sea biodiversity in ABNJ, enhancing open-access to data and samples, standardisation and international marine science cooperation are significant potential opportunity areas. 1 KEYWORDS: Law of the sea; international law; marine resources; ocean policy; marine genetic resources; areas beyond national jurisdiction; high seas; access and benefit sharing.

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Section: Resultsmentioning

confidence: 99%

Section: Lack Of Definition Of Mgr and Unclear Legal Status In Abnjmentioning

confidence: 99%

Section: Lack Of Definition Of Mgr and Unclear Legal Status In Abnjmentioning

confidence: 99%

Section: Lack Of Definition Of Mgr and Unclear Legal Status In Abnjmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Deep-sea genetic resources: New frontiers for science and stewardship in areas beyond national jurisdiction

Harden‐Davies

2017

Deep Sea Research Part II: Topical Studies in Oceanography

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A New Fusicoccane‐Type Norditerpene and a New Indone from the Marine‐Derived Fungus Aspergillus aculeatinus WHUF0198

Hong

et al. 2021

Chemistry & Biodiversity

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A new norditerpene named aculeaterpene A (1) and a new indone named aculeaindone A (2), along with eight known compounds 3–10 were isolated from the culture extract of Aspergillus aculeatinus WHUF0198. The structural characterization of compounds 1 and 2 were performed by spectroscopic analysis, including 1D and 2D NMR and HR‐ESI‐MS experiments, whereas the absolute configurations were determined by comparing their experimental or calculated ECD spectra. Compound 1 was the first report of fusicoccane‐based norditerpene, in which the C‐20 was degraded and tured into a hydroxy group.

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Cladosporioles A and B, Two New Indole Derivatives from the Deep‐Sea‐Derived Fungus Cladosporium cladosporioides 170056

Zou

Chen

et al. 2022

Chemistry & Biodiversity

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Two new (cladosporioles A and B, 1 and 2) and fourteen known (3–16) compounds were isolated from the deep‐sea‐derived fungus Cladosporium cladosporioides 170056. The relative structures of the new compounds were elucidated mainly by detailed analysis of their NMR and HR‐ESI‐MS spectroscopic data. Their absolute configurations were determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. All isolates were tested for antimicrobial activity against Vibrio parahaemolyticus. Compound 15 exhibited weak effect with the MIC value of 156.25 μg/mL.

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Recent advances in deep-sea natural products

Cited by 186 publications

References 215 publications

Deep-sea genetic resources: New frontiers for science and stewardship in areas beyond national jurisdiction

Deep-sea genetic resources: New frontiers for science and stewardship in areas beyond national jurisdiction

A New Fusicoccane‐Type Norditerpene and a New Indone from the Marine‐Derived Fungus Aspergillus aculeatinus WHUF0198

Cladosporioles A and B, Two New Indole Derivatives from the Deep‐Sea‐Derived Fungus Cladosporium cladosporioides 170056

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