Chemical constituents and biological activities of the fruits of <i>Knema pachycarpa</i> de Wilde

Giap, Tran Huu; Duc, Phan Minh; The, Nguyen Van; Popova, Milena; Bankova, Vassya; Hue, Cao Thi; Oanh, Vũ Thị Kim; Hang, Nguyen Thi Minh; Van, Hung Nguyen; Le, Thanh Nguyen

doi:10.1080/14786419.2019.1637868

Cited by 12 publications

(14 citation statements)

References 19 publications

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“…Phenolic compounds from natural sources have shown anticholinesterase activity in several studies [ 34 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 ]. Phenolic compounds whose anticholinesterase activities have been reported are given in the Supplementary Material ( Table S2 ).…”

Section: Discussionmentioning

confidence: 99%

Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources

et al. 2021

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Alzheimer’s disease (AD) is a severe neurodegenerative disorder of different brain regions accompanied by distresses and affecting more than 25 million people in the world. This progressive brain deterioration affects the central nervous system and has negative impacts on a patient’s daily activities such as memory impairment. The most important challenge concerning AD is the development of new drugs for long-term treatment or prevention, with lesser side effects and greater efficiency as cholinesterases inhibitors and the ability to remove amyloid-beta(Aβ) deposits and other related AD neuropathologies. Natural sources provide promising alternatives to synthetic cholinesterase inhibitors and many have been reported for alkaloids while neglecting other classes with potential cholinesterase inhibition. This review summarizes information about the therapeutic potential of small natural molecules from medicinal herbs, belonging to terpenoids, coumarins, and phenolic compounds, and others, which have gained special attention due to their specific modes of action and their advantages of low toxicity and high efficiency in the treatment of AD. Some show superior drug-like features in comparison to synthetic cholinesterase inhibitors. We expect that the listed phytoconstituents in this review will serve as promising tools and chemical scaffolds for the discovery of new potent therapeutic leads for the amelioration and treatment of Alzheimer’s disease.

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Section: Discussionmentioning

confidence: 99%

Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources

et al. 2021

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“…In Thailand, at least 12 different species have been identified . Previous investigations have reported the occurrence of diverse scaffolds: stilbenes, flavonoids, − lignans, , anacardic acid derivatives, , and alkyl/acyl resorcinols . These compounds exhibit antibacterial, antiviral, and acetylcholinesterase inhibitory activities …”

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confidence: 99%

α-Glucosidase Inhibitors from the Stems of Knema globularia

Danova

Aree

et al. 2022

J. Nat. Prod.

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Six new compounds, globunones A−F (1−6), and two new flavonoids (7 and 8) together with nine known compounds (9−17) were isolated from the stems of Knema globularia. The chemical structures of 1−8 were elucidated by an analysis of their NMR and high-resolution electrospray ionization mass spectrometry data as well as by comparison with literature values. The absolute configurations were determined using time-dependent density functional theory electronic circular dichroism (TD-DFT-ECD). Globunones A−E (1−5) represent the initial combined structures of a flavan-3-ol core and a 1,4-benzoquinone core. Globunone F (6) is the first flavanone-type compound bearing a 2-(2,4-dihydroxyphenyl)-2-oxoethyl group found to date in Nature. Compounds 1−3 and 6−17 were tested for their yeast α-glucosidase inhibitory activity. All compounds tested (except for 13 and 14) showed potent inhibition toward α-glucosidase with IC 50 values in the range 0.4−26.6 μM. Calodenin A (15) was the most active compound with an IC 50 value of 0.4 μM (the positive control, acarbose, IC 50 93.6 μM). A kinetic analysis of 15 revealed that it is a noncompetitive inhibitor with a K i value of 3.4 μM.

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“…Plant Knema pachycarpa de Wilde, that is called "Mau cho trai day", is a native tree in Viet Nam and only few chemical studies of this Knema species have been reported by our group [5][6][7]. In our biological activity screening of Vietnamese plants, the MeOH extract of leaves of K. pachycarpa showed cytotoxic activity against KB cell line with IC 50 of 78.21 ± 4.35 g/mL.…”

Section: Introductionmentioning

confidence: 86%

“…Cytotoxic activities of isolated metabolites against KB, HepG2, MCF7, and LU cancer cell lines were tested by the MTT assay, that was described in the previous paper [7]. The isolated compounds were diluted in dimethylsulfoxide (DMSO) at the following concentrations: 128, 32, 8, 2, and 0.5 μg/mL and used for the test.…”

Section: Cytotoxic Assaymentioning

confidence: 99%

“…In the continuation of our study on Knema plants, herein the chemical constituents of K. pachycarpa leaves were described. Seven phenolic compounds were isolated and elucidated as 5,7,3′-trihydroxy-5′-methoxy isoflavone (1), luteolin (2),(-)-narigenin (3), (+)-catechin (4), isoquercetrin (5), nicotiflorine (6), and 3,3',4,4'-tetrahydroxybiphenyl (7) by NMR and MS spectral data. The isolated compounds were evaluated for cytotoxicity against several cancer cell lines.…”

Section: Introductionmentioning

confidence: 99%

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Phenolic compounds from knema pachycarpa leaves

Giap

Hue

et al. 2023

Vietnam J. Sci. Technol.

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Knema (Myristicaceae family) is a large genus, comprising over 100 species found in of South East Asian countries, among that over 10 species was found in Vietnam. Knema pachycarpa is a native tree distributed in central provinces of Viet Nam. Until now, only few chemical studies of Knema species in Viet Nam have been reported. Phytochemical study of Knema pachycarpa leaves led to the isolation of seven known compounds including six flavonoids 5,7,3′-trihydroxy-5′-methoxy isoflavone (1), luteolin (2), (-)-narigenin (3), (+)-catechin (4), isoquercetrin (5), and nicotiflorin (6), and a biphenyl compound 3,3',4,4'-tetrahydroxybiphenyl (7). Their structures were elucidated by MS and NMR data analysis and compared with those previously reported. Compounds 3 and 6-7 were found from Knema genus for the first time. In the cytotoxic assay, biphenyl compound (7) exhibited strong cytotoxicity to KB cancer cell line with IC50 value of 2.38 ± 0.11 mg/mL. Compound 7 also displayed showed activity against HepG2, Lu and MCF7 cancer cell lines with IC50 ranges from 18.25 ± 0.92 mg/mL to 35.56 ± 1.17 mg/mL, whereas flavonoids 1-6 were weakly active or inactive against tested cell lines.

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Chemical constituents and biological activities of the fruits of Knema pachycarpa de Wilde

Cited by 12 publications

References 19 publications

Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources

Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources

α-Glucosidase Inhibitors from the Stems of Knema globularia

Phenolic compounds from knema pachycarpa leaves

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