α-Glucosidase Inhibitors from the Stems of <i>Knema globularia</i>

Le, Thi-Kim-Dung; Danova, Ade; Aree, Thammarat; Duong, Thuc‐Huy; Koketsu, Mamoru; Ninomiya, Masayuki; Sawada, Yoshiharu; Kamsri, Pharit; Pungpo, Pornpan; Chavasiri, Warinthorn

doi:10.1021/acs.jnatprod.1c00765

Cited by 22 publications

(14 citation statements)

References 46 publications

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“…α-Glucosidase is a carbohydrate hydrolyzing enzyme that maintains postprandial blood glucose and insulin levels [ 19 ]. The inhibition of this enzyme can delay intestinal carbohydrate digestion to control hyperglycemia in diabetes mellitus [ 20 ]. Exploration for new α-glucosidase inhibitors and other antidiabetic drugs from natural sources has increased in recent years [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

Alkaloids and Styryl lactones from Goniothalamus ridleyi King and Their α-Glucosidase Inhibitory Activity

et al. 2023

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Gonioridleylactam (1), a new compound, is a unique dimeric aristolactam isolated from the EtOAc extract of the twigs of Goniothalamus ridleyi King. The structure of gonioridleylactam (1) consists of two different aristolactams linked together with two methylenedioxy bridges at C–3/C–3′ and C–4/C–4′, generating a ten-membered ring of [1,3,6,8]tetraoxecine. A new natural product, gonioridleyindole (3-hydroxymethyl-1-methyl-1H-benz[f]indole-4,9-dione, 2), together with eight known compounds (3–10) were also isolated from this plant. Their structures were extensively characterized by spectroscopic methods and comparisons were made with the literature. Compounds 1–4, 7, and 9 were evaluated for their α-glucosidase inhibitory activity. Of these, 3,5-demethoxypiperolide (7) displayed the highest α-glucosidase inhibitory activity, with an IC50 value of 1.25 µM.

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Section: Resultsmentioning

confidence: 99%

Alkaloids and Styryl lactones from Goniothalamus ridleyi King and Their α-Glucosidase Inhibitory Activity

et al. 2023

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“…Le et al discovered six globunones A-F, two new flavonoids and nine other known compounds that displayed potent inhibition of α-glucosidase with IC 50 values between 0.4 and 26.6 μM. When compared to acarbose (IC 50 = 93.6 μM), the well-known flavonoid compound Calodenin A ( Figure 4 a) (IC 50 = 0.4 μM) had the greatest effect and exhibited a non-competitive mode of action during kinetic studies [ 114 ]. Similarly, Sgariglia et al [ 113 ] isolated five polyphenolic derivatives from the bark of Caesalpinia paraguariensis .…”

Section: Plant-derived Bioactive Compounds As Potential α-Glucosidase...mentioning

confidence: 99%

Recent Updates on Phytoconstituent Alpha-Glucosidase Inhibitors: An Approach towards the Treatment of Type Two Diabetes

Kashtoh

Baek

2022

Plants

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Diabetes is a common metabolic disorder marked by unusually high plasma glucose levels, which can lead to serious consequences such as retinopathy, diabetic neuropathy and cardiovascular disease. One of the most efficient ways to reduce postprandial hyperglycemia (PPHG) in diabetes mellitus, especially insulin-independent diabetes mellitus, is to lower the amount of glucose that is absorbed by inhibiting carbohydrate hydrolyzing enzymes in the digestive system, such as α-glucosidase and α-amylase. α-Glucosidase is a crucial enzyme that catalyzes the final stage of carbohydrate digestion. As a result, α-glucosidase inhibitors can slow D-glucose release from complex carbohydrates and delay glucose absorption, resulting in lower postprandial plasma glucose levels and control of PPHG. Many attempts have been made in recent years to uncover efficient α-glucosidase inhibitors from natural sources to build a physiologic functional diet or lead compound for diabetes treatment. Many phytoconstituent α-glucosidase inhibitors have been identified from plants, including alkaloids, flavonoids, anthocyanins, terpenoids, phenolic compounds, glycosides and others. The current review focuses on the most recent updates on different traditional/medicinal plant extracts and isolated compounds’ biological activity that can help in the development of potent therapeutic medications with greater efficacy and safety for the treatment of type 2 diabetes or to avoid PPHG. For this purpose, we provide a summary of the latest scientific literature findings on plant extracts as well as plant-derived bioactive compounds as potential α-glucosidase inhibitors with hypoglycemic effects. Moreover, the review elucidates structural insights of the key drug target, α-glucosidase enzymes, and its interaction with different inhibitors.

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“…Knema species have been used in the folk medicine to treat skin diseases, rheumatism and cancers [2]. Previous chemical investigations revealed the presence of phenol lipid derivatives, lignans, stilbenes and flavonoids from Knema plants [2][3][4]. Knema plant extracts and its active compounds showed many pharmacological effects such as anticancer, antidiabetic, antiinflammatory and acetylcholinesterase inhibitory activities [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Phenolic compounds from knema pachycarpa leaves

Giap

Hue

et al. 2023

Vietnam J. Sci. Technol.

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Knema (Myristicaceae family) is a large genus, comprising over 100 species found in of South East Asian countries, among that over 10 species was found in Vietnam. Knema pachycarpa is a native tree distributed in central provinces of Viet Nam. Until now, only few chemical studies of Knema species in Viet Nam have been reported. Phytochemical study of Knema pachycarpa leaves led to the isolation of seven known compounds including six flavonoids 5,7,3′-trihydroxy-5′-methoxy isoflavone (1), luteolin (2), (-)-narigenin (3), (+)-catechin (4), isoquercetrin (5), and nicotiflorin (6), and a biphenyl compound 3,3',4,4'-tetrahydroxybiphenyl (7). Their structures were elucidated by MS and NMR data analysis and compared with those previously reported. Compounds 3 and 6-7 were found from Knema genus for the first time. In the cytotoxic assay, biphenyl compound (7) exhibited strong cytotoxicity to KB cancer cell line with IC50 value of 2.38 ± 0.11 mg/mL. Compound 7 also displayed showed activity against HepG2, Lu and MCF7 cancer cell lines with IC50 ranges from 18.25 ± 0.92 mg/mL to 35.56 ± 1.17 mg/mL, whereas flavonoids 1-6 were weakly active or inactive against tested cell lines.

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α-Glucosidase Inhibitors from the Stems of Knema globularia

Cited by 22 publications

References 46 publications

Alkaloids and Styryl lactones from Goniothalamus ridleyi King and Their α-Glucosidase Inhibitory Activity

Alkaloids and Styryl lactones from Goniothalamus ridleyi King and Their α-Glucosidase Inhibitory Activity

Recent Updates on Phytoconstituent Alpha-Glucosidase Inhibitors: An Approach towards the Treatment of Type Two Diabetes

Phenolic compounds from knema pachycarpa leaves

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