Chemical Constituents and Biological Activities of Galinsoga parvifl ora Cav. (Asteraceae) from Egypt

Abstract

The phytochemical investigation of an aqueous ethanolic extract of Galinsoga parviflora Cav. (Asteraceae) resulted in the isolation and identification of eleven compounds namely: triacontanol, phytol, β-sitosterol, stigmasterol, 7-hydroxy-β-sitosterol, 7-hydroxystigmasterol, β-sitosterol-3-O-β-D-glucoside, 3,4-dimethoxycinnamic acid, protocatechuic acid, fumaric acid, and uracil. Furthermore, 48 volatile constituents were identified in the hydrodistilled oil of the aerial parts. The ethanolic extract at a content of 400 mg/kg body weight (BW) exerted 87% reduction in the alanine aminotransferase enzyme level in cirrhotic rats compared with the standard silymarin (150 mg/kg BW) and also exerted a reduction in the blood glucose level equivalent to that of glibenclamide (5 mg/kg BW) in diabetic rats. The ethanolic extract, light petroleum and ethyl acetate fractions exhibited substantial antimicrobial activity against Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli, Aspergillus niger, and Candida albicans. The ethyl acetate fraction showed strong antioxidant activity at a concentration of 150 mg/mL as compared with 0.1 M ascorbic acid. The cytotoxic effect against the MCF-7 cell line was found to be weak

Galinsoga parviflora (Cav.): A comprehensive review on ethnomedicinal, phytochemical and pharmacological studies

“…Most of the identified bioactive compounds possess remarkable medicinal qualities for the management of medical conditions such as malaria, flu, cold, colorectal cancer, liver ailments and skin diseases. The investigation of plant extracts revealed the presence eleven bioactive compounds including compounds 7, 9,12, 13, 14, 15, and 22 [ 14 ]. Similar study identified 48 bioactive compounds from hydrodistilled oil of the aerial parts of G. parviflora , where compound 29 being the most abundant component (45.66%), followed by compounds 27 (4.99%), 30 (4.95%), and 22 (4.39%) [ 14 ].…”

“…It is commonly employed for the management of both infectious and non-infectious diseases. Phytochemicals such as quercetin, beta sitosterol, gallic acid, kaempferol and hydrobenzoic acid have been identified from G. parviflora [ 14 ]. It has potential pharmacological properties including antibacterial [ 15 ], antimalarial [ 16 ], anti-oxidant [ 17 ], antidiabetic [ 14 ] and anti-inflammatory [ 18 ].…”

“…Phytochemicals such as quercetin, beta sitosterol, gallic acid, kaempferol and hydrobenzoic acid have been identified from G. parviflora [ 14 ]. It has potential pharmacological properties including antibacterial [ 15 ], antimalarial [ 16 ], anti-oxidant [ 17 ], antidiabetic [ 14 ] and anti-inflammatory [ 18 ]. However, the general audience needs to be explored by the information on its medical utilization as so far the availability of the collective information is limited regardless that it is widely studied.…”

Phytochemical Screening, Antioxidant, Anti-Cytotoxic and Anticancer Effects of Galinsoga Parviflora and Vernonia Polyanthes (Asteraceae) Extracts

“…Other studies indicate that G. parviflora exhibits a diversity of flavonoids derived from caffeic acid, steroids, among others [8], [55], [56] which is in accordance to the study of Bazylko et al [57], with ethanolic extract, that identified phenolic acids, such as caffeic, caffeoylquinic and dicafeoylquinic acid, using HPTLC; and also in accordance to the results of Dudek et al [55], with hydrophilic extract of aerial parts, that identified substances derived from caffeic acid, such as 5-O-caffeoylquinic acid (chlorogenic acid), 1, 3-O-dicaffeoylquinic acid, 3, 5-Odicafeoilquin, using spectrometric techniques. Meanwhile, the findings presented in our study (Table 5) corroborate those reported by Mostafa et al [56] and Anwar et al [58] that indicate the presence of stigmasterol, β-sitosterol and β-sitosterol in G. parviflora extracts. In addition, caffeic acid derivatives found in G. parviflora has been identified as an important protective factor for dermal fibroblasts against oxidative stress induced by ultraviolet radiation (UVA), by activating the cellular antioxidant system in a study by Parzonko and Kiss [59].…”

Synthesis, characterization, and antimicrobial properties of novel dual drug loaded electrospun mat for wound dressing applications

“…Moreover, the oral consumption of this extract treat symptoms of common cold, flu, and cold sores. 16,17 It also exhibits significant antibacterial, 18 antifungal, 19 and antiviral 20 properties. On the other hand, CQ belongs to Vitaceae and is spread throughout India.…”