Chemical Composition Profiling and Biological Activities of Phenolic Compounds in Eleven Red Sorghums

Li, Yanfang; Li, Ming; Liu, Jiaping; Zheng, Wenhao; Zhang, Yaqiong; Xu, Tao; Gao, Boyan; Yu, Liangli

doi:10.1021/acs.jafc.1c03115

Cited by 12 publications

(8 citation statements)

References 47 publications

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“…Similarly, the associations of TTC to DPPH • scavenging activity (r = 0.95), ABTS •+ scavenging activity (r = 0.97), and FRAP (r = 0.98) were strong and significant ( p < 0.001). The positive and significant correlations of TTC and TPC to each of the antioxidant activities demonstrate the roles of tannins and phenols in regulating ROS and RNS, which corroborate multiple other studies ( 4 , 11 , 39 ). In contrast, TTC, TPC, and antioxidant activities showed negative and/or weak correlations with individual fatty acids which could be the result of their distinct biosynthesis routes ( 54 , 59 ).…”

Section: Resultssupporting

confidence: 89%

“…In a typical way, IS8017 simultaneously displayed the highest levels of both luteolin (1.67 mg/g) and apigenin (6.35 mg/g). High concentrations of 3-deoxyanthocyanidins and flavonoids in sorghum seeds have attracted attention for their pronounced health benefits and disease protection, as well as for their potential use as food colorants ( 4 , 9 , 14 , 27 ). The breeding lines with high 3-deoxyanthocyanidins contents, particularly Gangwonsususu 6, JN69, JN 36, IS8089, and IS8123, may therefore be valuable resources.…”

Section: Resultsmentioning

confidence: 99%

“…Luteolinidin, apigeninidin, luteolin, and apigenin, were quantified using the corresponding external standards. 5-methoxyluteolinidin and 7-methoxyapigeninidin, with no available standards, were quantified as luteolinidin and apigeninidin equivalents, respectively multiplied by the appropriate correction factors ( 4 ). In each case, calibration curves were plotted at seven concentration levels of the standards (0.005–1 mg/mL) and the target metabolites were quantified from peak-area responses acquired from the UPLC-chromatograms.…”

Section: Methodsmentioning

confidence: 99%

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Exploring the potentials of sorghum genotypes: a comprehensive study on nutritional qualities, functional metabolites, and antioxidant capacities

et al. 2023

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IntroductionSorghum, long regarded as one of the most underutilized crops, has received attention in recent years. As a result, conducting multidisciplinary studies on the potential and health benefits of sorghum resources is vital if they are to be fully exploited. In this study, the nutritional contents, functional metabolites, and antioxidant capacities of 23 sorghum breeding lines and three popular cultivars were assessed.Materials and methodAll of the sorghum genotypes were grown under the same conditions, and mature seeds were hand-harvested. The metabolite contents and antioxidant capacities of sorghum seeds were assessed using standard protocols. Fatty acids were quantified using a gas chromatography-flame ionization detector, whereas flavonoids and 3-deoxyanthocyanidins were analyzed using a liquid chromatography-tandem mass spectrometry method. The data were analyzed using both univariate and multivariate statistical approaches.Results and discussionTotal protein (9.05–14.61%), total fat (2.99–6.91%), crude fiber (0.71–2.62%), dietary fiber (6.72–16.27%), total phenolic (0.92–10.38 mg GAE/g), and total tannin (0.68–434.22 mg CE/g) contents varied significantly across the sorghum genotypes (p < 0.05). Antioxidant capacity, measured using three assays, also differed significantly. Five fatty acids, including palmitic, stearic, oleic, linoleic, and linolenic acids, were found in all the sorghum genotypes with statistically different contents (p < 0.05). Furthermore, the majority of the sorghum genotypes contained four 3-deoxyanthocyanidins, including luteolinidin, apigeninidin, 5-methoxyluteolinidin, and 7-methoxyapigeninidin, as well as two dominant flavonoids, luteolin and apigenin. Compared to the cultivars, some breeding lines had significantly high levels of metabolites and antioxidant activities. On the other hand, statistical analysis showed that total tannin, total phenolic, and antioxidant capacities varied significantly across white, yellow, and orange genotypes. Principal component analysis was used to differentiate the sorghum genotypes based on seed color and antioxidant index levels. Pearson’s correlation analysis revealed strong links between biosynthetically related metabolites and those with synergistic antioxidant properties.ConclusionThis research demonstrated the diversity of the sorghum resources investigated. Those genotypes with high levels of nutritional components, functional metabolites, and antioxidant activities could be used for consumption and breeding programs.

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Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Exploring the potentials of sorghum genotypes: a comprehensive study on nutritional qualities, functional metabolites, and antioxidant capacities

et al. 2023

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“…As shown in Table 1, the TPC of SPs in FF and FP was 8.721 and 17.679 µmol FAE/g DS, respectively, and the TPC of IBPs in FF and FP was 7.544 and 12.903 µmol FAE/g DS, respectively. It can be observed that the TPC values of soluble fraction were higher than those of the insoluble fraction, whether in FF or FP of CFG, which is in agreement with previous studies of mistletoes [9] and red sorghums [17]. In addition, these results suggest that polyphenol molecules were more enriched in the FP than in the FF.…”

Section: Total Phenolic Content (Tpc) and Total Flavonoid Content (Tfc)supporting

confidence: 91%

UPLC–Q–TOF–MS/MS Analysis of Phenolic Compounds from the Fruit of Cephalostachyum fuchsianum Gamble and Their Antioxidant and Cytoprotective Activities

Wang

et al. 2022

Molecules

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Bamboo is a widely distributed graminaceous plant in China and is a potential source of bioactive substances. Incidentally, bamboo’s fruit is rich in phytochemicals such as polyphenols and flavonoids, which are significant to human health. In this study, we identified the phenolic compounds of the fruit and investigated the antioxidant activities of Cephalostachyum fuchsianum Gamble (CFG) fruit polyphenols with in vitro and in vivo tests for the first time. UPLC–Q–TOF–MS/MS analysis results showed that the fruit contained 43 phenolic compounds, including 7 hydroxybenzoic acids, 12 flavonoids, 7 coumarins, 10 hydroxycinnamic acids, 1 terpenoid, and 5 lignans. The TPC of SP extracts was higher than that of IBPs extracts in FP and FF. The SP extracts in FP showed better antioxidant activities in vitro compared to those in FF. In addition, polyphenols from CFG fruits protected against H2O2-induced oxidative damage in HepG2 cells, and the protective effect of polyphenols in FP was superior to that in FF. The analysis results showed that CFG fruit has great potential in exploiting natural chemical substances, which can provide valuable pieces of information for the further development and utilization of CFG.

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“…Flavonoids are the main compounds related to the sorghum pericarp color variation, especially anthocyanins and condensed tannins subclasses . Li et al found that the antioxidant capacity and total phenolic and flavonoid contents were similar among 11 genotypes of red sorghums. They also found that condensed tannins were significantly higher in soluble (free) fractions than in insoluble (bound) ones.…”

Section: Resultsmentioning

confidence: 99%

Overview of the Metabolite Composition and Antioxidant Capacity of Seven Major and Minor Cereal Crops and Their Milling Fractions

Ribeiro da Silva Lima,

Barros Santos,

P. Gomes

et al. 2024

J. Agric. Food Chem.

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Cereal grains play an important role in human health as a source of macro-and micronutrients, besides phytochemicals. The metabolite diversity was investigated in cereal crops and their milling fractions by untargeted metabolomics ultra-high-performance liquid chromatography−tandem mass spectrometry (UHPLC−MS/MS) of 69 samples: 7 species (barley, oat, pearl millet, rye, sorghum, triticale, and wheat), 23 genotypes, and 4 milling fractions (husk, bran, flour, and wholegrain). Samples were also analyzed by in vitro antioxidant activity. UHPLC−MS/MS signals were processed using XCMS, and metabolite annotation was based on SIRIUS and GNPS libraries. Bran and husk showed the highest antioxidant capacity and phenolic content/ diversity. The major metabolite classes were phenolic acids, flavonoids, fatty acyls, and organic acids. Sorghum, millet, barley, and oats showed distinct metabolite profiles, especially related to the bran fraction. Molecular networking and chemometrics provided a comprehensive insight into the metabolic profiling of cereal crops, unveiling the potential of coproducts and super cereals such as sorghum and millet as sources of polyphenols.

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Chemical Composition Profiling and Biological Activities of Phenolic Compounds in Eleven Red Sorghums

Cited by 12 publications

References 47 publications

Exploring the potentials of sorghum genotypes: a comprehensive study on nutritional qualities, functional metabolites, and antioxidant capacities

Exploring the potentials of sorghum genotypes: a comprehensive study on nutritional qualities, functional metabolites, and antioxidant capacities

UPLC–Q–TOF–MS/MS Analysis of Phenolic Compounds from the Fruit of Cephalostachyum fuchsianum Gamble and Their Antioxidant and Cytoprotective Activities

Overview of the Metabolite Composition and Antioxidant Capacity of Seven Major and Minor Cereal Crops and Their Milling Fractions

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