Chemical composition, potential toxicity, and quality control procedures of the crude drug of Cyrtopodium macrobulbon

Morales-Sánchez, Viridiana; Rivero‐Cruz, Isabel; Laguna-Hernández, Guillermo; Salazar, Gerardo A.; Mata, Rachel

doi:10.1016/j.jep.2014.05.006

Cited by 29 publications

(12 citation statements)

References 28 publications

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“…The alcoholic crude extract was suspended in water and sequentially extracted with cyclohexane, CH 2 Cl 2 and n-BuOH. The CH 2 Cl 2 extract was concentrated to dryness and subjected to silica gel column chromatography, Sephadex LH-20 and preparative thin layer chromatography (PTLC) to afford eight new compounds 1-8 ( Figure 1) together with 28 previously described compounds 9-35 which were identified as para-ethoxybenzyl alcohol (9) [18,19], 3,4,6-trimethoxyl-9,10-dihydrophenanthrene-2,7-diol (10) [20], confusarin (11) [21], erianthridin (12) [22], para-hydroxybenzaldehyde (13) [18], nudol (14) [23], cephathrene-B (15) [24], gigantol (16) [25], batatasin III (17) [26], ephemeranthoquinone (18) [27], coelonin (19) [28], 2,4-dimethoxy-phenanthrene-3,7-diol (20) [29], lusianthridin (21) [30], densiflorol B (22) [31], denthyrsinin (23) [32], bleformins A (24) and B (25) [33], chrysoeriol (26) [34,35], vanillic alcool (27) [36], gastrodigenin (28) [37,38], 1-(4-hydroxybenzyl)-4-methoxyl-9,10-dihydrophenanthrene-2,7-diol (29) [39], shancidin (30) …”

Section: Structure Elucidationmentioning

confidence: 99%

“…The phytochemical and biological investigations of this family has been mainly conducted in relation with their traditional uses and focused on a large number of Asian orchids from the genus Arundina, Bletilla, Dendrobium, Gastrodia and Pleione at the expense of the New World orchids In fact, the first report on a phytochemical study of South American orchids was in the late 1990s and was mainly focused on species in the genus Scaphyglottis [1-3], Maxillaria [4][5][6][7] and Cyrtopodium [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…G.A. Romero & Carnevali, a species traditionally used for treating urinary infections and whose stilbenoids are considered as its bioactive constituents [9]. C. paniculatum (Ruiz & Pav.)…”

Section: Introductionmentioning

confidence: 99%

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Chemical Constituents from the Aerial Parts of Cyrtopodium paniculatum

Auberon¹,

Olatunji²,

Herbette

et al. 2016

Molecules

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Abstract:We report the first phytochemical study of the neotropical orchid Cyrtopodium paniculatum. Eight new compounds, including one phenanthrene 1, one 9,10-dihydro-phenanthrene 2, one hydroxybenzylphenanthrene 3, two biphenanthrenes 4-5, and three 9,10 dihydrophenanthrofurans 6-8, together with 28 known phenolic compounds, mostly stilbenoids, were isolated from the CH 2 Cl 2 extract of its leaves and pseudobulbs. The structures of the new compounds were established on the basis of extensive spectroscopic methods.

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Section: Structure Elucidationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chemical Constituents from the Aerial Parts of Cyrtopodium paniculatum

Auberon¹,

Olatunji²,

Herbette

et al. 2016

Molecules

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show abstract

“…The monocot family Orchidaceae, which is evolutionarily more ancient than asterids and rosids, is one of the largest angiosperm families, including many medicinal, horticultural, and ornamental species. Orchid phytometabolites display antinociceptive, 35 antiangiogenic, 36 and antimycobacterial 37 activities, among others. In south Asia, orchid bulb is used for the treatment of asthma, bronchitis, throat infections, dermatological infections, and also as a blood purifier.…”

Section: Evolution Of Genome Gene and Genotypementioning

confidence: 99%

Genomics and Evolution in Traditional Medicinal Plants: Road to a Healthier Life

Hao

Xiao

2015

Evol Bioinform Online

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Medicinal plants have long been utilized in traditional medicine and ethnomedicine worldwide. This review presents a glimpse of the current status of and future trends in medicinal plant genomics, evolution, and phylogeny. These dynamic fields are at the intersection of phytochemistry and plant biology and are concerned with the evolution mechanisms and systematics of medicinal plant genomes, origin and evolution of the plant genotype and metabolic phenotype, interaction between medicinal plant genomes and their environment, the correlation between genomic diversity and metabolite diversity, and so on. Use of the emerging high-end genomic technologies can be expanded from crop plants to traditional medicinal plants, in order to expedite medicinal plant breeding and transform them into living factories of medicinal compounds. The utility of molecular phylogeny and phylogenomics in predicting chemodiversity and bioprospecting is also highlighted within the context of natural-product-based drug discovery and development. Representative case studies of medicinal plant genome, phylogeny, and evolution are summarized to exemplify the expansion of knowledge pedigree and the paradigm shift to the omics-based approaches, which update our awareness about plant genome evolution and enable the molecular breeding of medicinal plants and the sustainable utilization of plant pharmaceutical resources.

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“…Since the US Food and Drug Administration (FDA, Silver Spring, MD, USA) issued its Guidance for Industry , which initiated process analytical technology (PAT), various analytical technologies have been developed to guarantee the quality of the finished product. Chromatography/tandem mass spectrometry techniques are widely used for qualitative and quantitative detection, but they may be time‐consuming and information limited . In addition, imaging techniques have been exploited to examine tablet constitution, and these can provide both spectral and spatial information in the same assay.…”

Section: Introductionmentioning

confidence: 99%

In situ analysis of oxytetracycline tablets based on matrix‐assisted laser desorption/ionization mass spectrometry imaging

Xie

Zhao

et al. 2020

Rapid Comm Mass Spectrometry

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Rationale:A thorough understanding of the content and distribution of active ingredients in pharmaceuticals is essential for drug efficacy and safety.Technological advancements in mass spectrometry imaging present an opportunity for methodological innovation by providing qualification and quantification analysis, as well as spatial information, in the same assay, which has great potential for applications in the rapid analysis and quality control of drugs.Methods: Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was employed to directly analyze oxytetracycline tablets in order to map the distribution of the active constituent within the whole tablet. Quantitative analysis was capable of differentiating tablets containing various doses of the active pharmaceutical ingredient. Results:To establish the methodology, detailed factors that influence matrix spraying and spatial resolution during sample preparation and the data acquisition process were optimized systematically. Quantitative analysis could differentiate the tablets containing various doses of the active compound. The proposed method was successfully applied to analyze real commercial tablets. Conclusions:The developed method could successfully achieve the spatial location of oxytetracycline in actual tablet samples. These results could contribute to pharmaceutical tracing technology, especially the formulation process of tablets, which is helpful for monitoring the quality of pharmaceutical products and guaranteeing drug security.

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Chemical composition, potential toxicity, and quality control procedures of the crude drug of Cyrtopodium macrobulbon

Cited by 29 publications

References 28 publications

Chemical Constituents from the Aerial Parts of Cyrtopodium paniculatum

Chemical Constituents from the Aerial Parts of Cyrtopodium paniculatum

Genomics and Evolution in Traditional Medicinal Plants: Road to a Healthier Life

In situ analysis of oxytetracycline tablets based on matrix‐assisted laser desorption/ionization mass spectrometry imaging

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