Chemical composition of PM10 and its effect on in vitro hemolysis of human red blood cells (RBCs): a comparison study during dust storm and inversion

Faraji, Maryam; Pourpak, Zahra; Naddafi, Kazem; Nabizadeh, Ramin; Nicknam, Mohammad Hossein; Shamsipour, Mansour; Osornio-Vargas, Álvaro; Hassanvand, Mohammad Sadegh; Alizadeh, Zahra; Rezaei, Soheila; Mazinani, Marzieh; Soleimanifar, Narjes; Mesdaghinia, Alireza

doi:10.1007/s40201-018-00327-w

Cited by 11 publications

(6 citation statements)

References 43 publications

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“…PM 2.5 in Beijing during a pollution episode had a TD 10 value ranging from 1803.27 µg/mL to 3224.48 µg/mL, with an average of 2432.48 µg/mL. The TD 10 of PM 2.5 in this study was significantly higher than that in a previous study in Tehran, which concluded that the mean value TD 10 of PM 10 during a dust storm was 150 µg/mL and the mean value TD 10 of PM 10 during a weather inversion was 220 µg/mL [26]. This indicated that thanks to the implementation of a series of pollution prevention and control measures from 2013 to 2017, the source structure of PM 2.5 in Beijing has changed, and its chemical composition has also changed, resulting in a decrease in toxicity.…”

Section: Dose-response Relationship Between Hemolysis and Pm 25contrasting

confidence: 72%

“…Many methods have been used to assess the toxicity of particles, incorporating both in vivo [ 20 , 21 ] and in vitro methods [ 22 , 23 , 24 ]. Due to complicated experimental processes, long test periods, and high costs of in vivo methods, researchers are now utilizing in vitro protocols for rapid toxicological analysis of atmospheric PM, such as the hemolysis assay [ 25 , 26 ], plasmid scission assay (PSA) [ 27 ], and apoptosis assay [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Hemolytic Properties of Fine Particulate Matter (PM2.5) in In Vitro Systems

Bai,

Zhang,

Shao

et al. 2024

Toxics

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Epidemiological studies have suggested that inhalation exposure to particulate matter (PM) air pollution, especially fine particles (i.e., PM2.5 (PM with an aerodynamic diameter of 2.5 microns or less)), is causally associated with cardiovascular health risks. To explore the toxicological mechanisms behind the observed adverse health effects, the hemolytic activity of PM2.5 samples collected during different pollution levels in Beijing was evaluated. The results demonstrated that the hemolysis of PM2.5 ranged from 1.98% to 7.75% and demonstrated a clear dose–response relationship. The exposure toxicity index (TI) is proposed to represent the toxicity potential of PM2.5, which is calculated by the hemolysis percentage of erythrocytes (red blood cells, RBC) multiplied by the mass concentration of PM2.5. In a pollution episode, as the mass concentration increases, TI first increases and then decreases, that is, TI (low pollution levels) < TI (heavy pollution levels) < TI (medium pollution levels). In order to verify the feasibility of the hemolysis method for PM toxicity detection, the hemolytic properties of PM2.5 were compared with the plasmid scission assay (PSA). The hemolysis results had a significant positive correlation with the DNA damage percentages, indicating that the hemolysis assay is feasible for the detection of PM2.5 toxicity, thus providing more corroborating information regarding the risk to human cardiovascular health.

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Section: Dose-response Relationship Between Hemolysis and Pm 25contrasting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Hemolytic Properties of Fine Particulate Matter (PM2.5) in In Vitro Systems

Bai,

Zhang,

Shao

et al. 2024

Toxics

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“…Rats that were experimentally stressed using electric shock had lower RBC and hemoglobin in comparison with a non-stressed control group (Wei et al, 2008). Further, PM from dust and from coal-burning environments have increased hemolytic effects on RBC (Faraji et al, 2019;Zhang et al, 2022). The heavy metal portion of PM, specifically, appears to play a large role in determining the severity of the hemolytic effect (Zhang et al, 2022).…”

Section: Hematology and The Acute Phase Responsementioning

confidence: 99%

Effects of wildfire smoke exposure on innate immunity, metabolism, and milk production in lactating dairy cows

Anderson

Rezamand

Skibiel

2022

Journal of Dairy Science

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Wildfires are particularly prevalent in the Western United States, home to more than 2 million dairy cows that produce more than 25% of the nation's milk. Wildfires emit fine particulate matter (PM 2.5 ) in smoke, which is a known air toxin and is thought to contribute to morbidity in humans by inducing inflammation. The physiological responses of dairy cows to wildfire PM 2.5 are unknown. Herein we assessed the immune, metabolic, and production responses of lactating Holstein cows to wildfire PM 2.5 inhalation. Cows (primiparous, n = 7; multiparous, n = 6) were monitored across the wildfire season from July to September 2020. Cows were housed in freestall pens and thus were exposed to ambient air quality. Air temperature, relative humidity, and PM 2.5 were obtained from a monitoring station 5.7 km from the farm. Animals were considered to be exposed to wildfire PM 2.5 if daily average PM 2.5 exceeded 35 µg/m 3 and wildfire and wind trajectory mapping showed that the PM 2.5 derived from active wildfires. Based on these conditions, cows were exposed to wildfire PM 2.5 for 7 consecutive days in mid-September. Milk yield was recorded daily and milk components analysis conducted before, during, and after exposure. Blood was taken from the jugular vein before, during, and after exposure and assayed for hematology, blood chemistry, and blood metabolites. Statistical analysis was conducted using mixed models including PM 2.5 , temperature-humidity index (THI), parity (primiparous or multiparous), and their interactions as fixed effects and cow as a random effect. Separate models included lags up to 7 d to identify delayed and persistent effects from wildfire PM 2.5 exposure. Exposure to elevated PM 2.5 from wildfire smoke resulted in lower milk yield during exposure and for 7 d after last exposure and higher blood CO 2 concentration, which persisted for 1 d following exposure. We observed a positive PM 2.5 by THI interaction for eosinophil and basophil count and a negative PM 2.5 by THI interaction for red blood cell count and hemoglobin concentration after a 3-d lag.Neutrophil count was also lower with a combination of higher THI and PM 2.5 . We found no discernable effect of PM 2.5 on haptoglobin concentration. Effects of PM 2.5 and THI on metabolism were contingent on day of exposure. On lag d 0, blood urea nitrogen (BUN) was reduced with higher combined THI and PM 2.5 , but on subsequent lag days, THI and PM 2.5 had a positive interaction on BUN. Conversely, THI and PM 2.5 had a positive interacting effect on nonesterified fatty acids (NEFA) on lag d 0 but subsequently caused a reduction in circulating NEFA concentration. Our results suggest that exposure to high wildfire-derived PM 2.5 , alone or in concert with elevated THI, alters systemic metabolism, milk production, and the innate immune system.

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“…The pollutants in the dust combined with intensified desertification in China are resulting in more and longer DS events [ 12 , 13 ]. Particulate matter (PM) concentration levels also increase due to DS [ 13 , 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Dust Storms Increase the Risk of Age-Related Macular Degeneration

Chen

Liu

2022

IJERPH

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The main purpose of this study was to examine the association between dust storms (DSs) and age-related macular degeneration (AMD) using a 5 year representative national dataset with one million participants, according to information on DS, meteorology, and air pollution in Taiwan. There were 18,855 AMD outpatient cases and 1080 AMD inpatient cases during 2008–2012. A Poisson time-series model was used for the analysis. The results show that AMD cases are significantly associated with exposure to dust storm events. Average daily numbers of wet and dry AMD outpatient cases increased from 6.03 and 4.26 on no-event days to 8.25 and 6.67, 2 days after DSs. Average daily numbers of wet and dry AMD inpatient cases increased from 0.26 and 0.33 on no-event days to 0.58 and 0.75, 1 day after DSs. Both genders and different age groups are all affected by the occurrence of DSs, especially 1 and 2 days after DS events. Women are at a higher risk of outpatient visits and hospitalizations for relatively severe wet AMD. Although AMD highly correlated with age, this study also found that dry AMD outpatient visits in people under the age of 50 were also found to be significantly associated with DS events. In order to protect the health of eyes and avoid AMD, one should reduce or avoid outdoor activities when DS events occur.

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Chemical composition of PM10 and its effect on in vitro hemolysis of human red blood cells (RBCs): a comparison study during dust storm and inversion

Cited by 11 publications

References 43 publications

Hemolytic Properties of Fine Particulate Matter (PM2.5) in In Vitro Systems

Hemolytic Properties of Fine Particulate Matter (PM2.5) in In Vitro Systems

Effects of wildfire smoke exposure on innate immunity, metabolism, and milk production in lactating dairy cows

Dust Storms Increase the Risk of Age-Related Macular Degeneration

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