Chemical composition of essential oils of<i>Croton hirtus</i>L’Her from Piauí (Brazil)

Lima, Sidney Gonçalo de; Medeiros, Lídia B. P.; Cunha, César; Silva, D. da; Andrade, Nilza Campos de; Neto, José Machado Moita; Lopes, José Arimateia Dantas; Steffen, Rafael Augusto; Araújo, Bruno Quirino; Reis, Fabiano

doi:10.1080/10412905.2012.692908

Cited by 9 publications

(9 citation statements)

References 14 publications

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“…As significant toxicity was observed for BECF, it should be considered as an interesting characteristic to utilize this vegetal extract in further studies involving cytotoxicity. This is the first report of activity against A. salina for C. floribundus, however, the same activity has already been described for essential oils of other Croton species: fresh leaves of C. hirtus (Lima et al, 2012), the bark of C. niveus and C. monteverdensis (Werka et al, 2007). Moreover, several studies have reported a series of Croton species and their secondary metabolites with cytotoxicity on cancer cell lines (Liu et al, 2014;Wang et al, 2015;Zhang et al, 2015;Qiu et al, 2016), including C. floribundus (Uchoa et al, 2013), here it was observed that a compound (ent-kaur-16-en-6α,19-diol) isolated from hexane extract of root bark showed moderate effect against three cancer cell lines: MDA-MB-435 (melanoma), HCT-8 (colorectal adenocarcinoma) and HCT-116 (colorectal adenocarcinoma).…”

Section: Resultssupporting

confidence: 74%

Biological screening of extracts from leaf and stem bark of Croton floribundus Spreng. (Euphorbiaceae)

et al. 2018

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This work describes the preliminary evaluation of cytotoxic, antimicrobial, molluscicidal, antioxidant and anticholinesterase activities from leaf (LECF) and stem bark alcoholic extracts (BECF) of the species Croton floribundus Spreng. (Euphorbiaceae), popularly known as capixingui or tapixingui. BECF presented significant toxicity (LC50 = 89.6 μg/ml) in the Artemia salina Leach, 1819 (Crustacea: Branchiopoda) bioassay, whereas LECF did not show activity (LC50 > 1000 μg/ml). From DPPH method, the values of IC50 for the LECF and BECF were 61.2 μg/ml and 62.2 μg/ml, respectively, showing that C. floribundus has an expressive antioxidant activity. Antimicrobial susceptibility was evaluated by microdilution technique and only BECF was active against Staphylococcus aureus (MIC = 39.6 μg/ml). The extracts did not present molluscicidal activity against snail Biomphalaria glabrata Say, 1818 (Gastropoda: Planorbidae). Both extracts revealed the presence of several components with an inhibiting capacity of acetylcholinesterase enzyme on the bioautographic assay. C. floribundus showed to be a promising species considering that it exhibited good biological activity in the most assays performed.

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Section: Resultssupporting

confidence: 74%

Biological screening of extracts from leaf and stem bark of Croton floribundus Spreng. (Euphorbiaceae)

et al. 2018

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“…These data and the signals largely observed in the sugar region supported the MS identification of compound dehydro α ionol-O-[arabinosil (1)(2)(3)(4)(5)(6) glucoside]. Diagnostic signals for the isomer dehydro β ionol-O-[arabinosil (1)(2)(3)(4)(5)(6) glucoside] are the CH sp2 and by the HMBC with the CH at δ 72 and the secondary methyl group. A diffusion order spectroscopy experiment (DOSY) was also performed to observe different behavior of the various extracted phytochemicals present in the mixture.…”

Section: Introductionsupporting

confidence: 56%

“…The genus, Croton (Euphorbiaceae) comprises of about 1300 species, mostly widespread in tropical and subtropical regions of both hemispheres [ 1 ]. Several members of the genus are popular in folk medicine as they are commonly used against a range of illnesses such as inflammatory conditions, pain, diabetes, hypertension, malaria, gastrointestinal disturbances, and ulcers, amongst others [ 1 , 2 , 3 ]. Croton cajucara Benth., C. celtidifolius Baill., C. eluteria Bennett, C. zambesicus Müll.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, Daouda et al [ 2 ] have reported the antimicrobial action of C. hirtus essential oil, which was found to contain 93.49% of terpene derivatives, with 15.55% monoterpenes and 77.94% sesquiterpenes. In a study by de Lima, Medeiros, Cunha, da Silva, de Andrade, Neto, Lopes, Steffen, Araújo, and Reis [ 3 ], the presence of spathulenol (26.7%), E -caryophyllene (10.0%), bicyclogermacrene (9.5%), α-cadinol (7.7%), and cubenol (7.0%) as main constituents of the essential oils extracted from C. hirtus leaves was reported. In 2019, Rosandy, Azman, Khalid, Othaman, Lazim, Choudary, Syah, Latip, Said, and Bakar [ 4 ] identified two new diterpenoids from the roots of C. hirtus.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Antioxidant and Enzyme Inhibition Properties of Croton hirtus L’Hér. Extracts Obtained with Different Solvents

et al. 2021

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Croton hirtus L’Hér methanol extract was studied by NMR and two different LC-DAD-MSn using electrospray (ESI) and atmospheric pressure chemical ionization (APCI) sources to obtain a quali-quantitative fingerprint. Forty different phytochemicals were identified, and twenty of them were quantified, whereas the main constituents were dihydro α ionol-O-[arabinosil(1-6) glucoside] (133 mg/g), dihydro β ionol-O-[arabinosil(1-6) glucoside] (80 mg/g), β-sitosterol (49 mg/g), and isorhamnetin-3-O-rutinoside (26 mg/g). C. hirtus was extracted with different solvents—namely, water, methanol, dichloromethane, and ethyl acetate—and the extracts were assayed using different in vitro tests. The methanolic extracts presented the highest 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS), and ferric reducing antioxidant power (FRAP) values. All the tested extracts exhibited inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with a higher activity observed for dichloromethane (AChE: 5.03 and BChE: 16.41 mgGALAE/g), while the methanolic extract showed highest impact against tyrosinase (49.83 mgKAE/g). Taken together, these findings suggest C. hirtus as a novel source of bioactive phytochemicals with potential for commercial development.

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“…Nonterpenoid was isolated such as alkaloids, flavonoids, lignans and megastigmane glycosides [18]. Work on Brazilian C. hirtus has mainly concentrated on diterpenes [19] and essential oils [20]. So, with this background information, the aim of this present study are to analyse and characterize two new diterpenoid that have been isolated from root of genus using the spectroscopy NMR (1D and 2D), FT-IR and mass spectroscopy.…”

Section: Introductionmentioning

confidence: 99%

NEW DITERPENOIDS FROM THE ROOTS OF Croton hirtus (EUPHORBIACEAE)

Rosandy

Azman

Khalid³

et al. 2018

MJAS

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The root of Croton hirtus was collected at Tanjung Sepat, Banting for study of its chemical compounds. This sample was dried before being ground and extracted using the methanol solvent at room temperature for three days yielding 18.25 gram of crude extract. The crude extracts obtained were analysed using thin layer chromatography (TLC) then fractionated via vacuum column chromatography (VLC) and proceed the isolation using radial chromatography (RC) to get the pure compounds. The pure compounds obtained were elucidated by nuclear magnetic resonance (NMR), Fourier Transform Infrared (FT-IR) and mass spectroscopy to confirm their structures and from that analysis, the compounds were identified as two new compounds naming (-)-5,8-dihydroxyjatrophan-3-one (1) and (+)-14,16,17-trihydroxykauran-1-on (2) with total weight 4.9 mg and 4.5 mg respectively. This two compound were reported for this time on this genus.

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Chemical composition of essential oils ofCroton hirtusL’Her from Piauí (Brazil)

Cited by 9 publications

References 14 publications

Biological screening of extracts from leaf and stem bark of Croton floribundus Spreng. (Euphorbiaceae)

Biological screening of extracts from leaf and stem bark of Croton floribundus Spreng. (Euphorbiaceae)

Evaluation of Antioxidant and Enzyme Inhibition Properties of Croton hirtus L’Hér. Extracts Obtained with Different Solvents

NEW DITERPENOIDS FROM THE ROOTS OF Croton hirtus (EUPHORBIACEAE)

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