Chemical Composition, Biological and Cytotoxic Activities of Plant Extracts and Compounds Isolated from Ferula lutea

Znati, Mansour; Jannet, Hichem Ben; Cazaux, Sylvie; Bouajila, Jalloul

doi:10.3390/molecules19032733

Cited by 29 publications

(15 citation statements)

References 29 publications

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“…In previous reports, anti-AChE activities of the ethanolic extract of F. hermonis, the methanol extract of F. assafoetida, and the ethyl acetate and n-butanol extracts of F. lutea were studied, and all extracts showed low ability for inhibiting acetylcholinesterase. [37,41,50] There is no study about anti-BChE activity of the extracts from Ferula species, so this the first study about anti-BChE activity.…”

Section: Anticholinesterase Activitymentioning

confidence: 99%

“…Up to this time, antioxidant properties of various extracts (hexane, ethyl acetate, butanol, methanol, and ethanol) obtained from Ferula species (F. assafoetida, F. szowitsiana, F. microcolea, F. lutea, and F. hermonis) were investigated using different methods such as DPPH free and ABTS cation radical scavenging and metal chelating assays. [37][38][39][40][41] According to literature, generally the methanol extracts showed the highest antioxidant activity. The results are comparable to those of earlier studies.…”

Section: Antioxidant Activitymentioning

confidence: 99%

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Phenolic profile, antioxidant, anticholinesterase, and anti-tyrosinase activities of the various extracts ofFerula elaeochytrisandSideritis stricta

Deveci

Tel‐Çayan

Duru

2018

International Journal of Food Properties

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In this study, the antioxidant, anticholinesterase, and anti-tyrosinase properties of (hexane, acetone, methanol, and water) extracts of Ferula elaeochytris and Sideritis stricta were determined with the total phenolic and flavonoid contents. The phenolic profile of the methanol and water extracts was analysed using HPLC-DAD. Protocatechuic acid was found as the major phenolic compound in the methanol (116.3 ± 3.1 µg/g) and water extracts (69.4 ± 1.3 µg/g) of F. elaeochytris. Coumarins (253.9 ± 4.1 µg/g) and catechin hydrate (175.2 ± 2.9 µg/g) were the most abundant phenolic compounds in the methanol and water extracts of S. stricta. β-carotenelinoleic acid, DPPH • , ABTS •+ , CUPRAC, and metal-chelating assays were used to evaluate antioxidant properties of the extracts. The methanol and water extracts of F. elaeochytris and the acetone and methanol extracts of S. stricta containing the highest amount of total phenolic and flavonoid contents showed the highest antioxidant activities in β-carotene-linoleic acid, DPPH • , ABTS •+ , and CUPRAC assays. The enzyme inhibitory potential of extracts was investigated against key enzymes involved in neurodegenerative (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)) and skin (tyrosinase) disorders. In the cholinesterase inhibitory assays, the hexane extracts of two species exhibited the best activity against AChE, while the hexane extract of F. elaeochytris and the methanol extract of S. stricta observed to be the most active against BChE. As for anti-tyrosinase activity results of extracts, the only acetone and methanol extracts showed mild inhibitory activity for both species.

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Section: Anticholinesterase Activitymentioning

confidence: 99%

Section: Antioxidant Activitymentioning

confidence: 99%

Phenolic profile, antioxidant, anticholinesterase, and anti-tyrosinase activities of the various extracts ofFerula elaeochytrisandSideritis stricta

Deveci

Tel‐Çayan

Duru

2018

International Journal of Food Properties

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“…Methyl 3,5‐ O ‐dicaffeoylquinate and 3,5‐ O ‐dicaffeoylquinic acid from the flower of F. lutea Poir. significantly inhibit 5‐LOX enzyme, which catalyses the dioxygenation of polyunsaturated fatty acids to produce Hydroperoxyeicosatetraenoic acids and Hydroxyeicosatetraenoic Acids . Crude extract from F. persica and isolated active ingredients, persicasulphide and umbelliprenin, significantly inhibit MMP‐2 and 9, a family of endopeptidase which regulates destruction of extra cellular matrix and is involved in inflammatory arthritis …”

Section: Finding and Resultsmentioning

confidence: 99%

A mechanistic review on medicinal plants used for rheumatoid arthritis in traditional Persian medicine

Farzaei

Abdollahi

et al. 2016

Journal of Pharmacy and Pharmacology

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Objectives Rheumatoid arthritis (RA) is a chronic, inflammatory, autoimmune disease, which affects synovial tissue in multiple joints. Although conventional treatments of RA commonly alleviate the symptoms, high incidence of adverse reactions leads to research tendency towards complementary and alternative medicine. As various medicinal plants are traditionally used for the management of symptomatologies associated with RA in Persian medicine, we reviewed medicinal literature to confirm their efficacy in the management of RA. Key findings Scientific evidence revealed that traditional medicaments exert beneficial effects on RA through several cellular mechanisms including downregulation of pro-inflammatory cytokines such as TNF-a, IL-6 and NF-jB, suppression of oxidative stress, inhibition of cartilage degradation with destructive metalloproteinases and enhancement of antioxidant performance. Various active constituents from different chemical categories including flavonols, lignans, coumarins, terpenes, glycosylflavons, dihydroflavonols, phytoestrogens, sesquiterpene lactones, anthraquinones, alkaloids and thymoquinones have been isolated from the medicinal plants. Summary The pharmacological mechanisms of the medicinal plants traditionally used for RA in Persian medicine are discussed in the current review. Further investigations are mandatory to focus on bioefficacy of these phytochemicals for finding novel natural drugs.

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“…The genus Ferula is the main source of biologically active compounds, for instance, sesquiterpenes and coumarins. Recent studies have shown potent antioxidant, apoptotic activity, and cytotoxic effects of Ferula genus, as well [10][11][12]. Also, the cytotoxic impacts of methanolic extract of F. latisecta roots have been reported in preliminary screening assays of Soltani et al research.…”

Section: Introductionmentioning

confidence: 95%

Cytotoxic Effects of Ferula Latisecta on Human Glioma U87 Cells

et al. 2019

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Glioblastoma multiforme (GBM) is the fatal type of astrocytic tumors with a survival rate of 12 months. The present study, for the first time, evaluated the cytotoxic impacts of Ferula latisecta (F. latisecta) hydroalcoholic extract on U87 GBM cell line. The MTT assay measured the cellular toxicity following 24- and 48 h treatment with various doses of F. latisecta (0–800 μg/mL). Apoptosis was evaluated by an Annexin V/propidium iodide (PI) staining 24 h after treatment by F. latisecta. Moreover, to determine the cellular metastasis of U87 cells, we used a gelatin zymography assay (matrix metalloproteinase [MMP]-2/-9 enzymatic activity). The outcomes showed that F. latisecta mitigated the viability of U87 cells in a concentration- and time-dependent manner with IC50 values of 145.3 and 192.3 μg/mL obtained for 24- and 48 h treatments, respectively. F. latisecta induced apoptosis in a concentration-dependent manner after 24 h. Also, MMP-9 activity was significantly decreased following 24 h after treatment concentration-dependently with no change in MMP-2 enzymatic activity. This study showed that F. latisecta induced cytotoxicity and apoptosis, and mitigated metastasis of U87 GBM cells. Hence, F. latisecta could be beneficial as a promising natural herb against GBM after further studies.

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Chemical Composition, Biological and Cytotoxic Activities of Plant Extracts and Compounds Isolated from Ferula lutea

Cited by 29 publications

References 29 publications

Phenolic profile, antioxidant, anticholinesterase, and anti-tyrosinase activities of the various extracts ofFerula elaeochytrisandSideritis stricta

Phenolic profile, antioxidant, anticholinesterase, and anti-tyrosinase activities of the various extracts ofFerula elaeochytrisandSideritis stricta

A mechanistic review on medicinal plants used for rheumatoid arthritis in traditional Persian medicine

Cytotoxic Effects of Ferula Latisecta on Human Glioma U87 Cells

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