Chemical composition, antioxidant properties and hepatoprotective effects of chamomile (Matricaria recutita L.) decoction extract against alcohol-induced oxidative stress in rat

Abstract

Abstract. The present study assessed the chemical composition, antioxidant properties, and hepatoprotective effects of subacute pre-treatment with chamomile (Matricaria recutita L.) decoction extract (CDE) against ethanol (EtOH)-induced oxidative stress in rats. The colorimetric analysis demonstrated that the CDE is rich in total polyphenols, total flavonoids and condensed tannins, and exhibited an important in vitro antioxidant activity. The use of LC/MS technique allowed us to identify 10 phenolic compounds in CDE. We found that CDE pretreatment, in vivo, protected against EtOH-induced liver injury evident by plasma transaminases activity and preservation of the hepatic tissue structure. The CDE counteracted EtOH-induced liver lipoperoxidation, preserved thiol -SH groups and prevented the depletion of antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). We also showed that acute alcohol administration increased tissue and plasma hydrogen peroxide (H 2 O 2 ), calcium and free iron levels. More importantly, CDE pre-treatment reversed all EtOH-induced disturbances in intracellular mediators. In conclusion, our data suggest that CDE exerted a potential hepatoprotective effect against EtOH-induced oxidative stress in rat, at least in part, by negatively regulating Fenton reaction components such as H 2 O 2 and free iron, which are known to lead to cytotoxicity mediated by intracellular calcium deregulation.

A systematic review study of therapeutic effects of Matricaria recuitta chamomile (chamomile)

“…The chemical composition, antioxidant properties, and hepatoprotective effects of subacute pre-treatment with chamomile (Matricaria recutita L.) decoction extract (CDE) against ethanol (EtOH)-induced oxidative stress in rats was assessed, and it was suggested that CDE exerted a potential hepatoprotective effect against EtOH-induced oxidative stress in rats, at least in part, by negatively regulating Fenton reaction components such as H(2)O(2) and free iron, which are known to lead to cytotoxicity mediated by intracellular calcium deregulation ( 50 ).…”

Chamomile decoction extract inhibits human neutrophils ROS production and attenuates alcohol-induced haematological parameters changes and erythrocytes oxidative stress in rat

“…According to the study done in our laboratory, phytochemical studies of CDE revealed the presence of high concentrations of total polyphenols, total flavonoids, and condensed tannins. The use of HPLC-PDA-MS allowed to the identification of gallic acid, protocatechuic acid, chlorogenic acid, cafeic acid, cafeoylquinic acid, salicylic acid, quercetin, quinic acid derivative, hydroxybenzoic acid-O-hexoside, 5,7,4’-Trihydroxy-6,3’-dimethoxyflavone [ 52 ]. These molecules are the primal source of antioxidant ability of this plant that act as scavengers of free radicals [ 53 ].…”

Antidiarrhoeal, antimicrobial and antioxidant effects of myrtle berries (Myrtus communis L.) seeds extract

“…In our study, phytochemical analysis also revealed an important amount of tannins in the myrtle berries seeds aqueous extract containing 26.25 ± 01.27 mg TAE/g DM and 4.49 ± 0.27 mgCE/g DM respectively for total and condensed tannins. However, MBSAE tannins contents appear higher than those of other medicinal plants such as Matricaria recutita , Punica granatum and Securidaca longepedunculata . Indeed, besides their antioxidant activity, these molecules are implicated in the regulation of intestinal hypersecretion .…”