Chemical composition, antimicrobial and anti-acetylcholinesterase activities of essential oil from Lantana camara (Verbenaceae) flowers

Abstract

Lantana camara L. is considered a weed, but is used in agriculture and traditional medicine due to its different pharmacological effects. The objective of this study was to determine the chemical composition and the bioactivity of essential oil from L. camara flowers collected in Boa Vista, Roraima, Brazil. Essential oil was obtained using a Clevenger type apparatus. The oil obtained was analyzed by gas chromatography coupled to flame ionization detector (GC-FID) and gas chromatography coupled to mass spectrometer detector (GC-MS) and its bioactivity was assayed against fungi and bacteria, as well as for acetylcholinesterase inhibition. The chemical composition of essential oil presented major compounds contrasting with the literature, while its bactericidal and fungicidal activity was excellent, reaching over than 90% inhibition against yeast. A potent anti-acetylcholinesterase activity, superior than 77% inhibition, was also observed.

Composition, Seasonal Variation, and Biological Activities of Lantana camara Essential Oils from Côte d’Ivoire

“…Different solvent extracts produced from L. camara have already been studied, showing the occurrence of flavonoids, triterpenes, and glycosides [5]. These extracts and compounds were described as having interesting antioxidant, anti-inflammatory [11][12][13], antibacterial, cytotoxic, antifungal, anthelmintic [14][15][16][17][18], and insecticidal properties [19,20]. Some studies have also focused on L. camara essential oils, showing the high diversity in essential oil compositions depending on plant growth area.…”

Plantas brasileiras com ação anticolinesterásica – uma revisão

“…No trabalho desenvolvido por Silva et al (2014b) com o extrato etanólico das folhas do Limãozinho (Zanthoxylum syncarpum -Rutaceae) os autores obtiveram uma moderada atividade de inibição da AChE com 0,6 cm na placa de CCD em comparação ao padrão fisostigmina que foi de 0,9 cm. Santos et al (2015) utilizando o óleo essencial das flores de Camará (Lantana âmara -Verbenaceae) conseguiram um alta inibição da acetilcolinesterase no ensaio de microdiluição, com um resultado de 77,15%.…”