Chemical composition, anti-inflammatory and antinociceptive effects of the butanolic fraction of Annona nutans (Annonaceae) leaves

Silva, Nathália Lucca; Saldanha, Aline Aparecida; Vieira, Letícia; Silva, Denise Brentan; Carollo, Carlos Alexandre; Sartori, Ângela Lúcia Bagnatori; Ribeiro, Rosy Iara Maciel de Azambuja; Thomé, Ralph Gruppi; Santos, Hélio Batista dos; Soares, Adriana Cristina; Siqueira, João Máximo de

doi:10.1080/14786419.2020.1774758

Cited by 3 publications

(1 citation statement)

References 17 publications

(3 reference statements)

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“…Amazonian species from the Anonnaceae family were described as having promising pharmacological activities, including anti-inflammatory (Silva et al 2021), antimalarial (Nughara et al 2019), anticancer, antimicrobial (Costa et al 2010Tundis et al 2017;Paz et al 2019;Costa et al 2021) and antiviral (Yu et al 2019;Warowicka et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Anti-herpes activity of the total alkaloid fraction from the branches of Fusaea longifolia (Annonaceae)

et al. 2023

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The herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) occur worldwide. Infections caused by these viruses have great public health importance due to the growing resistance to the first-choice drug, acyclovir, especially in immunosuppressed patients. Alkaloids derived from species of Annonaceae have been reported as antiviral agents against HSV and others viruses. Within this context, we evaluated the antiviral activity of the total alkaloid fraction (TAF) extracted from the branches of Fusaea longifolia (Aubl.) Saff. (Annonaceae), a species native to the Amazon region, against the HSV-1 and HSV-2 viruses. The antiviral activity was evaluated through the plate reduction assay and the mode of action was investigated by a set of other assays. The TAF was active against the HSV-2 strain 333 and against the HSV-1 strains KOS and 29R (acyclovir resistant), with selectivity index values (SI = 50% cytotoxic concentration/50% effective concentration) of 5, 4 and 3, respectively. In the preliminary study of the anti-HSV-2 mode of action, TAF showed viral inhibitory effects if added up to 12 h post-infection, had virucidal activity and did not present viral inhibition in pre-treatment. Our results showed that the TAF exhibited anti-HSV activity. Regarding HSV-2, TAF acted after the viral infection and had virucidal activity. A mass spectrometry analysis revealed the presence of nine alkaloids in the TAF that had previously been reported for Annonaceae, including liriodenine, lysicamine and isoboldine, which have been described as potential anti-HSV-1 agents.

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Section: Introductionmentioning

confidence: 99%

Anti-herpes activity of the total alkaloid fraction from the branches of Fusaea longifolia (Annonaceae)

et al. 2023

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Anti-inflammatory and antinociceptive effects, toxicity, and phytochemical analysis of Beaumontia grandiflora Wall.

Yang,

Teng,

Yang

et al. 2024

Natural Product Research

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Phytochemical screening and potential antioxidant, antibacterial and anti-melanoma activities of Rollinia dolabripetala leaves

Campos¹,

Oliveira²,

Silva-Júnior³

et al. 2022

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Plants are an important source of natural compounds used for medicine. The Annonaceae family exhibits a cytotoxic effect on different tumor strains and on several bacterial strains. This unprecedented study investigates the antioxidant, anti-melanoma, anti-staphylococcal and anti-streptococcal potential of hydroalcoholic extracts of Rollinia dolabripetala leaves and of 1.7 -dihydroxyxanthone and xanthone phytocompounds. The determination of the antioxidant capacity was performed by the DPPH and lipid peroxidation methods. Isolated phytochemicals xanthone and 1.7-dihydroxyxanthone were also included in cytotoxicity and antimicrobial tests. Assays for antitumor leaf potential were performed on melanoma carcinogenic cells and assays for antibacterial potential were performed on Gram-positive Staphylococcus aureus 29213 (SA13), S. aureus 4075 (SA75) and Streptococcus bovis-01 (SB01) strains. The phytochemical prospection revealed the presence of flavonols, tannins and xanthones. Halo inhibition (mm) of Gram-positive SA13 was 7.00 ± 0.38. There was no inhibitory effect on SA75 and SB01 strains. The antitumor activity, expressed in the minimum lethal concentration (GI50) was in μg/mL: R. dolabripetala: 47.04, 1.7-dihydroxyxanthone: 0.98, Xanthone: 3.38, and 5-Fluorouracil: 0.24. When comparing treatments with 5-Fluorouracil, the best correlation between dosage and the inhibition rate occurs with 1.7-dihydroxy-xanthone followed by R. dolabripetala treatment. In conclusion, R. dolabripetala exhibits antioxidant, anti-staphylococcal and anti-melanoma bioactivities with 1.7-dihydroxy-xanthone exhibiting the best correlation between dosage and inhibition rate. Phytochemicals such as, flavonols, tannins and xanthone reinforce the biological results obtained. The seasonal factor in the collection of plant samples may explain the discrepancies in the phytochemical data of R. dolabripetala compared to other species of the genus.

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Chemical composition, anti-inflammatory and antinociceptive effects of the butanolic fraction of Annona nutans (Annonaceae) leaves

Cited by 3 publications

References 17 publications

Anti-herpes activity of the total alkaloid fraction from the branches of Fusaea longifolia (Annonaceae)

Anti-herpes activity of the total alkaloid fraction from the branches of Fusaea longifolia (Annonaceae)

Anti-inflammatory and antinociceptive effects, toxicity, and phytochemical analysis of Beaumontia grandiflora Wall.

Phytochemical screening and potential antioxidant, antibacterial and anti-melanoma activities of <i>Rollinia dolabripetala</i> leaves

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