Chemical composition and therapeutic effects of Lippia alba (Mill.) N. E. Brown leaves hydro-alcoholic extract in patients with migraine

Conde, Raul; Correa, Valéria S. C.; Carmona, Fábio; Contini, Sílvia Helena Taleb; Pereira, Ana Maria Soares

doi:10.1016/j.phymed.2011.06.016

Cited by 32 publications

(12 citation statements)

References 22 publications

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“…CHM has been gradually gaining acceptance worldwide [26][27][28][29]. ere have been a number of laboratory experiments [30][31][32], clinical trials [33], and systematic reviews with meta-analyses [34][35][36][37] evidence supporting CHM as a potential alternative therapy for migraine.…”

Section: Introductionmentioning

confidence: 99%

Oral Chinese Herbal Medicine as Prophylactic Treatment for Episodic Migraine in Adults: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Lyu

Zhang²,

Guo

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. The prophylactic effects of Chinese herbal medicine (CHM) for migraine were examined in numerous clinical trials. This review aimed to analyze the effectiveness and safety of CHM as prophylactic treatment of migraine compared to flunarizine. Methods. Nine databases were searched for randomized controlled trials (RCTs) that evaluated effects of CHM for episodic migraine prophylaxis compared to flunarizine, published before March 2019. Results. Thirty-five RCTs with 2,840 participants met the inclusion criteria, and 31 of them were included in meta-analyses. The overall meta-analysis indicated that, when compared to flunarizine, CHM reduced the frequency of migraine attacks at the end of treatment (EoT) (21 studies, mean difference (MD) −1.23, 95% confidence interval (CI) (−1.69, −0.76)) and at the end of follow-up (EoFU) (five studies, MD −0.96, 95% CI (−1.70, −0.21)). Subgroup analyses based on the treatment duration, follow-up duration, and the dosage of flunarizine showed that CHM was superior to or comparable with flunarizine in reducing migraine frequency. Similar results were also found for secondary outcomes such as the pain visual analogue scale, migraine duration, responder rate, and acute medication usage. In particular, the studies that used CHM containing herb pairs (Chuan Xiong plus Bai Zhi and Chuan Xiong plus Tian Ma) showed promising results. However, the certainty of this evidence was evaluated as “low” or “very low” using the Grading of Recommendations, Assessment, Development and Evaluations approach. Conclusion. CHM appeared to be comparable with flunarizine in reducing the frequency of episodic migraine attacks in adults at EoT and EoFU and well-tolerated by participants, regardless of the treatment duration, follow-up duration, and dosage of flunarizine. Due to the low certainty of the evidence, the suggested promising prophylactic outcomes require higher quality evidence from further rigorous RCTs.

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Section: Introductionmentioning

confidence: 99%

Oral Chinese Herbal Medicine as Prophylactic Treatment for Episodic Migraine in Adults: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Lyu

Zhang²,

Guo

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…L. alba has a long history of used as food preservative and in the traditional medicine. Plant has used traditionally as anti‐inflammatory, anticonvulsivant, and myorelaxant as well as effective in several other human diseases (Conde and others ). With significant medicinal properties, plant has also good essential oil content.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Some Essential Oils Against Aspergillus flavus with Special Reference to Lippia alba Oil an Inhibitor of Fungal Proliferation and Aflatoxin B₁ Production in Green Gram Seeds during Storage

Pandey

Sonker

Singh

2016

Journal of Food Science

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During mycofloral analysis of green gram (Vigna radiata (L.) R. Wilczek) seed samples taken from different grocery stores by agar and standard blotter paper methods, 5 fungal species were identified, of which Aspergillus flavus exhibited higher relative frequency (75.20% to 80.60%) and was found to produce aflatoxin B1 . On screening of 11 plant essential oils against this mycotoxigenic fungi, Lippia alba essential oil was found to be most effective and showed absolute inhibition of mycelia growth at 0.28 μL/mL. The oil of L. alba was fungistatic and fungicidal at 0.14 and 0.28 μL/mL, respectively. Oil had broad range of fungitoxicity at its MIC value and was absolutely inhibited the AFB1 production level at 2.0 μL/mL. Chemical analysis of this oil revealed geranial (36.9%) and neral (29.3%) as major components followed by myrcene (18.6%). Application of a dose of 80 μL/0.25 L air of Lippia oil in the storage system significantly inhibited the fungal proliferation and aflatoxin production without affecting the seed germination rate. By the virtue of fungicidal, antiaflatoxigenic nature and potent efficacy in storage food system, L. alba oil can be commercialized as botanical fungicide for the protection of green gram seeds during storage.

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“…These yield percent and composition variation in essential oils of same species from different habitats are due to differences in the geographical origin, time of extraction and plant part used for the extraction 30 . Other factors such as genotype, chemotype, environmental and agronomic conditions, can all influence the composition of the final natural product 31 .…”

Section: Discussionmentioning

confidence: 99%

“…Plant essential oils are consisting of complex mixtures of monoterpenes and sesquiterpenes and the toxic properties of essential oils are associated with smaller group of the constituents, acting additively or synergistically 31 . Earlier scholars investigated the monoterpenes and sesquiterpenes as major insecticidal agents in plant essential oils.…”

Section: Discussionmentioning

confidence: 99%

Repellent and Fumigant Activities of <i>Tanacetum nubigenum</i> Wallich. ex DC Essential Oils against <i>Tribolium castaneum</i> (Herbst) (Coleoptera: Tenebrionidae)

et al. 2015

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Chemical composition and therapeutic effects of Lippia alba (Mill.) N. E. Brown leaves hydro-alcoholic extract in patients with migraine

Cited by 32 publications

References 22 publications

Oral Chinese Herbal Medicine as Prophylactic Treatment for Episodic Migraine in Adults: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Oral Chinese Herbal Medicine as Prophylactic Treatment for Episodic Migraine in Adults: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Efficacy of Some Essential Oils Against Aspergillus flavus with Special Reference to Lippia alba Oil an Inhibitor of Fungal Proliferation and Aflatoxin B₁ Production in Green Gram Seeds during Storage

Repellent and Fumigant Activities of <i>Tanacetum nubigenum</i> Wallich. ex DC Essential Oils against <i>Tribolium castaneum</i> (Herbst) (Coleoptera: Tenebrionidae)

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Chemical composition and therapeutic effects of Lippia alba (Mill.) N. E. Brown leaves hydro-alcoholic extract in patients with migraine

Cited by 32 publications

References 22 publications

Oral Chinese Herbal Medicine as Prophylactic Treatment for Episodic Migraine in Adults: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Oral Chinese Herbal Medicine as Prophylactic Treatment for Episodic Migraine in Adults: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Efficacy of Some Essential Oils Against Aspergillus flavus with Special Reference to Lippia alba Oil an Inhibitor of Fungal Proliferation and Aflatoxin B1 Production in Green Gram Seeds during Storage

Repellent and Fumigant Activities of <i>Tanacetum nubigenum</i> Wallich. ex DC Essential Oils against <i>Tribolium castaneum</i> (Herbst) (Coleoptera: Tenebrionidae)

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Efficacy of Some Essential Oils Against Aspergillus flavus with Special Reference to Lippia alba Oil an Inhibitor of Fungal Proliferation and Aflatoxin B₁ Production in Green Gram Seeds during Storage