Chemical composition and the inhibition of acetyl cholinesterase activity of Centella asiatica from Quang Tho village, Quang Dien district, Thua Thien – Hue province
Abstract:Centella asiatica is a very popular plant in Vietnam and in other South and Southeast Asia. It grows wildly or planted in all parts of Vietnam. People use this plant for treatment of many diseases or as a vegetable. This plant is a main product of economic importance in Quang Tho village, Quang Dien district, Thua Thien -Hue province, where it is planted according to VIETGAP standard. The MeOH extract from the aerial parts of Centella asiatica collected from Quang Tho village has shown a good inhibition of ace… Show more
“…As a Vietnamese traditional medicine, Centella asiatica Linn (called "Rau má" in Vietnamese) has been widely studied and used as a wound healing, memory enhancer, and anti-aging agent. The saponins, triterpenoids, including asiaticoside, madecassoside, centelloside, and flavonoids regarded as biomarker components have been isolated in this herbal drug [5,6]. However, the pentacyclic triterpenoids components in Centella are known to depend on its growth location and the diverse environmental conditions it is subjected to [7,8].…”
Section: Introductionmentioning
confidence: 99%
“…Tạ Thị Thảo 1,* , Nguyễn Diệu Linh 1 , Nguyễn Thị Hà Ly 2 , Hoàng Thị Tuyết 2 , Đỗ Thị Hà 2 , Nguyễn Lâm Hồng 3 , Trần Thị Huế 4 , Nguyễn Đức 5 , Phạm Gia Bách 1 ,1 Khoa Hóa học, Trường ĐH Khoa học Tự nhiên, ĐH QGHN2 Viện Dược liệu Trung ương3 Bộ môn Kiểm nghiệm thuốc và độc chất, Trường ĐH Dược Hà Nội 4 Khoa Hóa học, Trường ĐH Sư phạm Thái Nguyên, ĐH Thái Nguyên5 Học viện Quân Y Mạng nơ ron nhân tạo (ANN), một lĩnh vực của học máy, hiện đã được ứng dụng rộng rãi trong hóa học phân tích với nhiều mục đích khác nhau như phân loại/nhận dạng mẫu, dự đoán và mô hình hóa. Nghiên cứu này cho thấy ANN đóng vai trò quan trọng như một phương pháp hồi quy phi tuyến, kết hợp với phương pháp quang phổ UV để giải quyết vấn đề chồng phổ sử dụng ma trận chứa nền mẫu phức tạp của thuốc thảo dược.…”
The artificial neuron network (ANN), which is a subfield of machine learning, has been widely applied in analytical chemistry for classification/pattern recognition, prediction, and modeling. ANN combined with UV spectrometry can be used to tackle the problem of overlapping spectra of a complicated matrix of herbal medicine. In the present study, ANN has been used for simultaneous determination of asiaticoside andmadecassoside in Centella asiatica collected from various provinces in Viet Nam based on UV spectra of standard reference and spiked samples. The absorption spectra of 108 C. asiatica samples were recorded in (190-250) nm of wavelength with an interval of 1 nm (61 variables) were used for data acquisition. An ANN model using traincgb function with 40 neural hidden layers was trained. The correlation coefficients were all higher than 0.9999. The concentration of asiaticoside and madecassoside in all tested samples revealed a good recovery, as compared to the referenced values. TheANN model can be considered as effective, time-saving and environment-friendly quantitative analysis tool for herbal medicine
® 2024 Journal of Science and Technology - NTTU
“…As a Vietnamese traditional medicine, Centella asiatica Linn (called "Rau má" in Vietnamese) has been widely studied and used as a wound healing, memory enhancer, and anti-aging agent. The saponins, triterpenoids, including asiaticoside, madecassoside, centelloside, and flavonoids regarded as biomarker components have been isolated in this herbal drug [5,6]. However, the pentacyclic triterpenoids components in Centella are known to depend on its growth location and the diverse environmental conditions it is subjected to [7,8].…”
Section: Introductionmentioning
confidence: 99%
“…Tạ Thị Thảo 1,* , Nguyễn Diệu Linh 1 , Nguyễn Thị Hà Ly 2 , Hoàng Thị Tuyết 2 , Đỗ Thị Hà 2 , Nguyễn Lâm Hồng 3 , Trần Thị Huế 4 , Nguyễn Đức 5 , Phạm Gia Bách 1 ,1 Khoa Hóa học, Trường ĐH Khoa học Tự nhiên, ĐH QGHN2 Viện Dược liệu Trung ương3 Bộ môn Kiểm nghiệm thuốc và độc chất, Trường ĐH Dược Hà Nội 4 Khoa Hóa học, Trường ĐH Sư phạm Thái Nguyên, ĐH Thái Nguyên5 Học viện Quân Y Mạng nơ ron nhân tạo (ANN), một lĩnh vực của học máy, hiện đã được ứng dụng rộng rãi trong hóa học phân tích với nhiều mục đích khác nhau như phân loại/nhận dạng mẫu, dự đoán và mô hình hóa. Nghiên cứu này cho thấy ANN đóng vai trò quan trọng như một phương pháp hồi quy phi tuyến, kết hợp với phương pháp quang phổ UV để giải quyết vấn đề chồng phổ sử dụng ma trận chứa nền mẫu phức tạp của thuốc thảo dược.…”
The artificial neuron network (ANN), which is a subfield of machine learning, has been widely applied in analytical chemistry for classification/pattern recognition, prediction, and modeling. ANN combined with UV spectrometry can be used to tackle the problem of overlapping spectra of a complicated matrix of herbal medicine. In the present study, ANN has been used for simultaneous determination of asiaticoside andmadecassoside in Centella asiatica collected from various provinces in Viet Nam based on UV spectra of standard reference and spiked samples. The absorption spectra of 108 C. asiatica samples were recorded in (190-250) nm of wavelength with an interval of 1 nm (61 variables) were used for data acquisition. An ANN model using traincgb function with 40 neural hidden layers was trained. The correlation coefficients were all higher than 0.9999. The concentration of asiaticoside and madecassoside in all tested samples revealed a good recovery, as compared to the referenced values. TheANN model can be considered as effective, time-saving and environment-friendly quantitative analysis tool for herbal medicine
® 2024 Journal of Science and Technology - NTTU
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