A systematic review and meta-analysis extraction techniques to reach the optimum asiaticoside content from the edible plant of Centella asiatica

Okselni, Tia; Septama, Abdi Wira; Pamungkas, Rian Adi; Rahmi, Eldiza Puji; Efdi, Mai; Koketsu, Mamoru

doi:10.1016/j.sajb.2023.02.019

Cited by 5 publications

(3 citation statements)

References 81 publications

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“…Moreover, preparing extracts by MAE and UAE with EtOH improved extraction efficiency, resulting in an increased yield and total pentacyclic triterpene content. Okselni and co-workers reported an extraction technique with the optimal AS yield from C. asiatica in the systematic review and meta-analysis results [ 61 ]. Our process also decreased the time and energy needed for drying and dissolving the extract and had a high yield of C. asiatica extract and PRE, especially for recovering the pentacyclic triterpene mixture (that is, AA, MA, AS, and MS) content at more than 68%w/w.…”

Section: Resultsmentioning

confidence: 99%

Preparation, development, and scale-up of standardized pentacyclic triterpenoid-rich extract from Centella asiatica (L.) Urb. and study of its wound healing activity

Rachpirom¹,

Pichayakorn²,

Puttarak³

2023

Heliyon

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Section: Resultsmentioning

confidence: 99%

Preparation, development, and scale-up of standardized pentacyclic triterpenoid-rich extract from Centella asiatica (L.) Urb. and study of its wound healing activity

Rachpirom¹,

Pichayakorn²,

Puttarak³

2023

Heliyon

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“…Pada penelitian ini digunakan metode yang mudah dan sederhana yaitu maserasi (Gambar 1). Metanol merupakan pelarut yang paling cocok untuk maserasi pada suhu kamar [19]. Metanol direkomendasikan sebagai pelarut yang optimal untuk mendapatkan kandungan fitokimia yang tinggi serta antioksidan yang tinggi [20].…”

Section: Metode Ekstraksi Sampelunclassified

Potensi Madu dan Ekstrak Ampas Teh Sebagai Penghambat Tirosinase Untuk Bahan Aktif Kosmetika Pemutih

Sumarlin,

Ernita,

Hajar

2023

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One way to lighten skin tone is to inhibit the formation of melanin through the inhibition of the tyrosinase enzyme. Bleach acts as an inhibitor of melanin production and is known as a competitive tyrosinase inhibitor. In this study, the potential for teabag and honey dregs will be analyzed singly and in the form of a mixture. The method used is an anti-tyrosinase test using L-DOPA as a substrate. The results of the analysis showed that the tea extract samples were almost all positive test compounds (Flavonoids, Alkaloids, Tannins, Saponins, Steroids) except for Quinones and Triterpenoids. Honey for the positive sample was only for saponin compounds, while those for other compounds were negative. Tea extract has the potential to inhibit the tyrosinase enzyme, because it contains flavonoid compounds, tannins and steroids. Tests for inhibition of the tyrosinase enzyme in honey and tea and a mixture of the two have IC50 values 1000 g/ml, so the inhibitory activity is very weak. However, research has shown that tea bag dregs and honey have the potential to be used as active ingredients in whitening cosmetics.

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“…Other factors like temperature and duration also play important roles for optimizing the yields of the triterpenoids(Okselni et al, 2023). The choice of method will also depend upon whether the desired application requires aglycones or glycosides.…”

mentioning

confidence: 99%

Comparison of organic and conventional production methods in accumulation of biomass and bioactive compounds in Centella asiatica (L.) urban

Tran,

Pham,

Nguyen

et al. 2023

Preprint

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Centella asiatica is a herb commonly grown across south and southeast Asia for nutritional and traditional medicinal value. Recent studies have shown that triterpenoids and their glycosides produced by C. asiatica may have applications in modern medicines. It is therefore important to determine how best to culture the herb to maximise the production of bioactive compounds while minimising any negative impact upon the environment or the health of the farmers. We have compared Vietnam Good Agricultural Practice (VIETGAP) with an organic (ORGANIC) production technique in Thua Thien-Hue province, Vietnam. This paper reports the results of the collection and analysis of the fresh mass, the dry mass, the raw ethanol/water extracts, and the levels of the main bioactive triterpenoids: madecassic, asiatic and terminolic acids over the course of two years. We found that the ratios of the dry mass to fresh mass, and extracts to dry mass were similar in both cases, with maximum raw extracts/dry mass ratios of 37% (VIETGAP) and 33% (organic). We have monitored these changes with respect to the seasons and found that the best time to harvest for bioactive compounds in this location is June-September, when the weather is warmer and drier. These results show that switching to an organic production method is not detrimental to the accumulation of valuable bioactive compounds, and we anticipate that application of these results will contribute to increasing the economic and social value of Centella asiatica while reducing the use of agrochemicals which can be deleterious to the environment and the health of farmers.

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A systematic review and meta-analysis extraction techniques to reach the optimum asiaticoside content from the edible plant of Centella asiatica

Cited by 5 publications

References 81 publications

Preparation, development, and scale-up of standardized pentacyclic triterpenoid-rich extract from Centella asiatica (L.) Urb. and study of its wound healing activity

Preparation, development, and scale-up of standardized pentacyclic triterpenoid-rich extract from Centella asiatica (L.) Urb. and study of its wound healing activity

Potensi Madu dan Ekstrak Ampas Teh Sebagai Penghambat Tirosinase Untuk Bahan Aktif Kosmetika Pemutih

Comparison of organic and conventional production methods in accumulation of biomass and bioactive compounds in Centella asiatica (L.) urban

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