Chemical Composition and Pharmacological Activity of Garden Savory (Satureja hortensis L.) Occurring in Georgia

Кемертелидзе, Э. П.; Sagareishvili, T. G.; Сыров, В. Н.; Хушбактова, З. А.

doi:10.1023/b:phac.0000048144.98876.10

Cited by 16 publications

(6 citation statements)

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“…The leaves of summer savory are rich in phenolic compounds, particularly rosmarinic acid and flavonoids, which account for the high antioxidant capacity of these leaves [ 4 , 5 ]. In our previous study of Georgian spices, we found that kondari had one of the highest total phenolic content levels and one of the highest hydrophilic antioxidant capacity levels [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Rosmarinic Acid-Rich Extracts of Summer Savory (Satureja hortensisL.) Protect Jurkat T Cells against Oxidative Stress

Chkhikvishvili

Sanikidze

Gogia

et al. 2013

Oxidative Medicine and Cellular Longevity

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Summer savory (Satureja hortensis L., Lamiaceae) is used in several regions of the world as a spice and folk medicine. Anti-inflammatory and cytoprotective effects of S. hortensis and of its rosmarinic acid-rich phenolic fraction have been demonstrated in animal trials. However, previous studies of rosmarinic acid in cell models have yielded controversial results. In this study, we investigated the effects of summer savory extracts on H2O2-challenged human lymphoblastoid Jurkat T cells. LC-MS analysis confirmed the presence of rosmarinic acid and flavonoids such as hesperidin and naringin in the phenolic fraction. Adding 25 or 50 µM of H2O2 to the cell culture caused oxidative stress, manifested as generation of superoxide and peroxyl radicals, reduced cell viability, G0/G1 arrest, and enhanced apoptosis. This stress was significantly alleviated by the ethanolic and aqueous extracts of S. hortensis and by the partially purified rosmarinic acid fraction. The application of an aqueous S. hortensis extract doubled the activity of catalase and superoxide dismutase in the cells. The production of IL-2 and IL-10 interleukins was stimulated by H2O2 and was further enhanced by the addition of the S. hortensis extract or rosmarinic acid fraction. The H2O2-challenged Jurkat cells may serve as a model for investigating cellular mechanisms of cytoprotective phytonutrient effects.

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Section: Introductionmentioning

confidence: 99%

Rosmarinic Acid-Rich Extracts of Summer Savory (Satureja hortensisL.) Protect Jurkat T Cells against Oxidative Stress

Chkhikvishvili

Sanikidze

Gogia

et al. 2013

Oxidative Medicine and Cellular Longevity

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“…(familia Lamiaceae) (20) . Asimismo, Kemertelidze et al encontraron en el extracto acuoso de Satureja hortensis L. una gran cantidad de polifenoles, específicamente flavonoides (21) . De forma similar, el extracto acuoso de Satureja montana, tuvo proporciones altas de compuestos fenólicos, especialmente de ácido cafeico y rutina (22) .…”

Section: Discussionunclassified

Estructura química de compuestos fenólicos del extracto etanólico de hojas de Clinopodium pulchellum (Kunth) Govaerts “panisara”

Tuesta

Carhuamaca

Barrientos

et al. 2017

Rev. per. med. integr.

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Objetivos. Proponer la estructura quimica de componentes fenolicos aislados del extracto etanolico de hojas de Satureja pulchella “panisara”, quien en la actualidad presenta el nombre de Clinopodium pulchellum (Kunth) Govaerts y evaluar preliminarmente el posible efecto antioxidante de los compuestos fenolicos. Materiales y Metodos. Se realizo una identificacion fitoquimica mediante ensayos de solubilidad, tamizaje fitoquimico, cromatografia en capa fina y espectroscopia UV/VIS. Por otro lado, se realizo un ensayo preliminar de la actividad antioxidante usando la prueba de 1,1-difenil-2-picrilhidracilo (DPPH). Resultados. Se determino que el extracto etanolico de hojas de Clinopodium pulchellum (Kunth) Govaerts “panisara” es soluble en solventes polares. Los metabolitos secundarios encontrados son compuestos fenolicos tipo flavonoides, alcaloides, quinonas y glicosidos. Se propone siete estructuras quimicas de flavonoides a traves del analisis de los espectros UV/Vis, y mediante comparacion con lo publicado por TJ Mabry y Olga Lock. Al realizar el ensayo preliminar de la actividad antioxidante usando la prueba de 1,1-difenil-2-picrilhidracilo (DPPH) se observo disminucion de absorbancia, al aplicar el extracto frente al control. Conclusiones. Se propone la estructura quimica de 7 metabolitos secundarios tipo flavonas que podrian explicar una posible accion antioxidante del extracto etanolico de hojas de Clinopodium pulchellum (Kunth) Govaerts “panisara”.

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“…Tsimogiannis et al [ 101 ] identified luteolin-7-O-rutinoside in the ethanol extract of S. thymbra . This compound has been also identified in S. hortensis and S. montana [ 102 , 104 ].…”

Section: Pink Savorymentioning

confidence: 99%

Six Common Herbs with Distinctive Bioactive, Antioxidant Components. A Review of Their Separation Techniques

et al. 2021

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Rosemary, oregano, pink savory, lemon balm, St. John’s wort, and saffron are common herbs wildly grown and easily cultivated in many countries. All of them are rich in antioxidant compounds that exhibit several biological and health activities. They are commercialized as spices, traditional medicines, or raw materials for the production of essential oils. The whole herbs or the residues of their current use are potential sources for the recovery of natural antioxidant extracts. Finding effective and feasible extraction and purification methods is a major challenge for the industrial production of natural antioxidant extracts. In this respect, the present paper is an extensive literature review of the solvents and extraction methods that have been tested on these herbs. Green solvents and novel extraction methods that can be easily scaled up for industrial application are critically discussed.

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Chemical Composition and Pharmacological Activity of Garden Savory (Satureja hortensis L.) Occurring in Georgia

Cited by 16 publications

References 1 publication

Rosmarinic Acid-Rich Extracts of Summer Savory (Satureja hortensisL.) Protect Jurkat T Cells against Oxidative Stress

Rosmarinic Acid-Rich Extracts of Summer Savory (Satureja hortensisL.) Protect Jurkat T Cells against Oxidative Stress

Estructura química de compuestos fenólicos del extracto etanólico de hojas de Clinopodium pulchellum (Kunth) Govaerts “panisara”

Six Common Herbs with Distinctive Bioactive, Antioxidant Components. A Review of Their Separation Techniques

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