Chemical composition and in vitro antioxidant evaluation of a water-soluble Moldavian balm (Dracocephalum moldavica L.) extract

Dastmalchi, Keyvan; Dorman, H. J. Damien; Koşar, Müberra; Hiltunen, R.

doi:10.1016/j.lwt.2005.09.019

Cited by 172 publications

(135 citation statements)

References 23 publications

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“…The prevention of the chain initiation step by scavenging various reactive species such as free radicals is considered to be an important antioxidant mode of action (Dastmalchi et al 2007). The DPPH free radical scavenging ability of the free and bound phenolic extracts of the citrus peels as presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…DPPH free radical scavenging ability is frequently used in the determination of free radical scavenging ability; however it has the limitation of colour interference and sample solubility (Dastmalchi et al 2007). Therefore, the free radical scavenging ability of the free and bound phenolic extracts was further studied using a moderately stable nitrogen-centred radical species -ABTS radical (Re et al 1999).…”

Section: Resultsmentioning

confidence: 99%

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Characterization of the antioxidant properties of phenolic extracts from some citrus peels

2011

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This study sought to determine the distribution of free and bound phenolics in some Nigerian citrus peels [orange (Citrus sinensis), grapefruit (Citrus paradisii) and shaddock (Citrus maxima)] and characterize the antioxidant properties. The free phenolics were extracted with 80% acetone, while the bound phenolics were extracted from the alkaline and acid hydrolyzed residue with ethyl acetate. Free phenolic extracts had significantly higher (P < 0.05) DPPH* scavenging ability than the bound phenolic extracts, except in orange peels where the bound phenolic extracts had significantly higher (P<0.05) DPPH* scavenging ability. Bound phenolics from orange peels had the highest ABTS* scavenging ability (6.09 mmol./TEAC g) and ferric reducing antioxidant properties (FRAP) (71.99 mg/GAE 100 g), while bound phenolics from shaddock peels had the least ABTS* scavenging ability (1.35 mmol./TEAC g) and FRAP (2.58 mg/GAE 100 g) . Bound phenolics from grapefruit peels had the highest OH* scavenging ability (EC 50 = 3.8 mg/ml), while bound phenolics from shaddock peels had the least (EC 50 =16.1 mg/ml). The phenolics chelated Fe 2+ and inhibited malondialdehyde production in rat's pancreas in a dose-dependent manner. The additive and/or synergistic action of the free and bound phenolics could have contributed to the observed medicinal properties of the peels; therefore, the high antioxidant properties of the free and bound phenolic extracts from orange peels could be harness in the formulation of nutraceuticals and food preservatives.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Characterization of the antioxidant properties of phenolic extracts from some citrus peels

2011

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“…Reducing properties is a defense system with two pathways obtainable to have an impact on this property are by e -transfer and hydrogen transfer. 14,30 The reducing capacity of the extracts could also be a sign of its potential antioxidant activities owing to the presence of reductants. DPPH assays assess the power to scavenge radicals.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effect of Bryophyllum pinnatum (Lam.) Oken leaf extract and their fractions on α-amylase, α-glucosidase and cholinesterase enzyme

Ojo¹,

Ojo²,

Ajiboye³

et al. 2018

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Bryophyllum pinnatum (Lam.) Oken leaves are employed as food and as traditional medicines. This study investigates the antioxidant activity (reducing power, DPPH, ABTS, FRAP, H 2 O 2 scavenging ability and metal ion chelating), carbohydrate digesting enzymes activity and inhibitory activity of cholinergic enzyme of aqueous extract and fractions (n-hexane, ethyl acetate, n-butanol, residual aqueous fraction) of B. pinnatum leaves were investigated. Results showed that aqueous extract of B. pinnatum exhibited DPPH radical scavenging abilities, iron chelation, hydrogen peroxide scavenging abilities and reducing power (Fe 3+ -Fe 2+ ). B. pinnatum aqueous extract also had considerably α-amylase and α-glucosidase inhibitory activities with IC 50 values 149.20 ± 14.44 µg/mL and 126.15 ± 9.76 µg/mL respectively. Our findings indicated that ethyl acetate fraction contained a considerably higher (p < 0.05) amount of total phenolic, flavonoids, total antioxidant, FRAP, metal ion, ABTS and DPPH radical scavenging activity than other solvent fractions. Furthermore, the ethyl acetate fraction elicited a significantly higher (p < 0.05) inhibitory effects on α-glucosidase (IC 50 = 70.90 ± 1.23 μg/ml), α-amylase (IC 50 = 62.45 ± 1.22 μg/ml), acetylcholinesterase (AChE) (IC 50 = 66.75 µg/mL) and butyrylcholinesterase (BChE) (IC 50 = 62.97 µg/mL) activities than other fractions. Hence, B. pinnatum leaves were rich in biologically active components; thus, could be employed to formulate new plant-based pharmaceutical and nutraceutical drugs to improve human health.

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“…118 A quantificação de compostos fenólicos é realizada por meio de uma variedade de métodos; todavia, o que utiliza o reagente de FolinCiocalteau (RFC) é o mais extensivamente empregado. [119][120][121][122] O RFC consiste de mistura dos ácidos fosfomolibídico e fosfotungstico, na qual o molibdênio se encontra no estado de oxidação (VI) (cor amarela no complexo Na 2 MoO 4 .2H 2 O); porém, em presença de certos agentes redutores, como os compostos fenólicos, formam-se os chamados complexos molibdênio-tungstênio azuis [(PMoW 11 O 4 ) 4-], nos quais a média do estado de oxidação dos metais está entre 5 (V) e 6 (VI) e cuja coloração permite a determinação da concentração das substâncias redutoras que, não necessariamente, precisam ter natureza fenólica. 113,123 A Figura 1 mostra a desprotonação dos compostos fenólicos (no exemplo, o padrão ácido gálico) em meio básico, gerando os ânions fenolatos.…”

Section: Método De Folin-ciocaulteauunclassified

Fontes vegetais naturais de antioxidantes

et al. 2009

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Chemical composition and in vitro antioxidant evaluation of a water-soluble Moldavian balm (Dracocephalum moldavica L.) extract

Cited by 172 publications

References 23 publications

Characterization of the antioxidant properties of phenolic extracts from some citrus peels

Characterization of the antioxidant properties of phenolic extracts from some citrus peels

Inhibitory effect of Bryophyllum pinnatum (Lam.) Oken leaf extract and their fractions on α-amylase, α-glucosidase and cholinesterase enzyme

Fontes vegetais naturais de antioxidantes

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