Chemical composition and hypoglycaemic effect of polyphenol extracts from Litchi chinensis seeds

Man, Shuli; Ma, Jiang; Wang, Chunxia; Yu, Liang; Gao, Wenyuan; Lu, Fuping

doi:10.1016/j.jff.2016.01.032

Cited by 42 publications

(39 citation statements)

References 33 publications

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“…Additionally, no significant changes were observed regarding the body mass/body length ratio ( p > 0.05). The high-fat (HF) diet and diabetic status had a significant effect ( p < 0.05) on the rats’ relative kidney mass (% of body weight), of up to 1.4-fold higher than NDB group, being in agreement with previously reported data for HF/STZ-induced diabetic rats [ 35 ]. Other tissues such as liver, spleen, heart, testes, pancreas and femur bones were not remarkably affected ( p > 0.05).…”

Section: Resultssupporting

confidence: 91%

Effect of Elderberry (Sambucus nigra L.) Extract Supplementation in STZ-Induced Diabetic Rats Fed with a High-Fat Diet

Salvador

Król

Lemos

et al. 2016

IJMS

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Elderberry (Sambucus nigra L.) lipophilic and polar extract dietary supplementation effects were evaluated according to diabetes management indices, using an in vivo model. A research pipeline was constructed, that ranged from extract preparation, partial chemical characterization and toxicity evaluation, to examining the elderberry extract dietary supplementation effects on biofluid and tissues. Extracts toxicity was screened using an Aliivibrio fischeri bioluminescence model. A concentration of up to 60 mg/L was selected, and rat doses for oral supplementation were computed applying the interspecies correlation between A. fischeri and rats. Wistar type 2 diabetic rats, induced by streptozotocin (STZ), were fed a high-fat diet and supplemented for 4 weeks at doses of 190 and 350 mg/kg body weight/day of lipophilic and polar extract, respectively. As far as we know, lipophilic elderberry extract supplementation was assessed for the first time, while polar extract was administrated at higher doses and for a shorter period compared to previous studies, aiming to evaluate subacute supplementation effects. The polar extract modulated glucose metabolism by correcting hyperglycemia, while the lipophilic extract lowered insulin secretion. Both extracts lowered insulin resistance, without remarkable alterations to hematological indices, sera lipids and sera and tissular trace element homeostasis. In conclusion, elderberries are a potential source of bioactive compounds for formulations to be used as co-adjuvants in diabetes management.

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Section: Resultssupporting

confidence: 91%

Effect of Elderberry (Sambucus nigra L.) Extract Supplementation in STZ-Induced Diabetic Rats Fed with a High-Fat Diet

Salvador

Król

Lemos

et al. 2016

IJMS

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“…Daily consumption of 200mg of oligonol for 10 weeks in 18 Japanese volunteers, aged 24-59 years, resulted in a significant reduction in Body Mass Index and fat tissue mass, along with a decrease of 15% of visceral and 6% of the subcutaneous fat 42 . The peel of the lychee contains a large amount of flavonoids and polyphenols; therefore, the flour of this fruit part has a higher concentration of antioxidants than the fresh fruit 7,43 . The seed contains proanthocyanidins, flavonoids, steroids, and sesquiterpenes 44 , and therefore, can be used as a natural source of antioxidants.…”

Section: Discussionmentioning

confidence: 99%

“…The fruit has a sweet odor of rose and traditionally are used as tonic to heart, brain and liver 5 due to their abundant polyphenols and flavonoids. Because of its attractive color and delicious taste, lychee has been widely accepted by consumers 7 . The possibility of developing a potential food ingredient capable of preventing obesity and retarding lipid oxidation from lychee is significant 8 .…”

Section: Introductionmentioning

confidence: 99%

Can lychee reducing the adipose tissue mass in rats?

Almeida

Ferreira

Augusto-Obara

et al. 2018

Braz. arch. biol. technol.

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Lychee fruit has been studied owing to the presence of several bioactive compounds that can contribute to weight loss in obese individuals. However, the anti-obese potential of the fruit has not been explored yet. The aim of this study was to investigate the effect of different parts of lychee in reducing the adipose tissue mass of cafeteria diet-fed rats. Phenolic compounds and scavenging capacities were quantified. The food intake, apparent digestibility, weight of the body and liver, body mass, Lee Index, and the mass of epididymal and visceral adipose tissues were evaluated. The results were estimated by Tukey's Test at 5% probability. A higher amount of phenolic compounds and scavenging capacity were observed in the peel of lychee as compared to the other parts of the fruit. The hypercaloric diet with lychee flour resulted in a higher apparent digestibility. There was no difference between groups control (C), hypercaloric (H), hypercaloric with lychee flour-50.00% peel and 50.00% seeds (H2F), and hypercaloric with lychee flour-33.33% peel, 33.33% pulp and 33.34% seeds (H3F) with respect to body and liver weight, corporal mass, and Lee Index. The hypercaloric diet-fed group exhibited an increase in visceral and epididymal adipose tissue mass, whereas the group fed with hypercaloric diets and flour made from the peel and seed of lychee presented a lower visceral adipose tissue mass. In conclusion, the use of lychee flour was considered viable because it decreased visceral adipose tissue mass in rats.

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“…Pharmacological studies have revealed that the seed of Litchi chinensis possesses multiple pharmacological activities, such as modulating blood glucose, moderating insulin resistance and sensitivity of epigallocatechin gallate (Xu et al 2010;Zhang et al 2018), and blood lipids (Jaiswal and Kumar 2015), and preventing liver injury (Zhang et al 2018), oxidation (Jaiswal and Kumar 2015), virus (Guo et al 2017) and tumour (Zhao et al 2007) activities. The seeds of Litchi chinensis contain remarkable amounts of phenolic compounds such as protocatechuic acid, protocatechuic aldehyde, procyanidin D, (-)-epicatechin, cinnamtannin B1, procyanidin A1, rutin and phlorizin (Man et al 2016(Man et al , 2017. In addition, it also contains glycosides such as litchioside D, taxifolin 4 0 -O-b-D-glucopyranoside and kaempferol 7-O-neohesperidoside (Xu et al 2011;Wang et al 2017).…”

Section: Introductionmentioning

confidence: 99%

The seed of Litchi chinensis fraction ameliorates hippocampal neuronal injury in an Aβ_25-35-induced Alzheimer’s disease rat model via the AKT/GSK-3β pathway

Sun

Xiu

et al. 2019

Pharmaceutical Biology

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Context: The seed of Litchi chinensis Sonn., a famous traditional Chinese medicine, was recently reported to enhance cognitive function by inhibiting neuronal apoptosis in rats. Objective: We determined whether the seed of Litchi chinensis fraction (SLF) can ameliorate hippocampal neuronal injury via the AKT/GSK-3b pathway. Materials and methods: We established Alzheimer's disease (AD) model by infusing Ab 25-35 into the lateral ventricle of Sprague-Dawley (SD) rats and randomly divided into five groups (n ¼ 10): sham, donepezil and SLF (120, 240 and 480 mg/kg/d). Rats were treated by intragastric administration for 28 consecutive days. Spatial learning and memory were evaluated with Morris water maze, while protein expression of AKT, GSK-3b and tau in the hippocampal neurons was measured by Western blotting and immunohistochemistry. Results: On the fifth day, escape latency of the AD model group was 45.78 ± 2.52 s and that of the sham operative group was 15.98 ± 2.32 s. SLF could improve cognitive functions by increasing the number of rats that crossed the platform (p < 0.01), and their platform quadrant dwell time (p < 0.05). The protein expression level of AKT was upregulated (p < 0.001), while that of GSK-3b and tau (p < 0.01) was remarkably downregulated in the hippocampal CA1 area. Discussion and conclusions: To our knowledge, the present study is the first to show that SLF may exert neuroprotective effect in AD rats via the AKT/GSK-3b signalling pathway, thereby serving as evidence for the potential utility of SLF as an effective drug against AD.

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Chemical composition and hypoglycaemic effect of polyphenol extracts from Litchi chinensis seeds

Cited by 42 publications

References 33 publications

Effect of Elderberry (Sambucus nigra L.) Extract Supplementation in STZ-Induced Diabetic Rats Fed with a High-Fat Diet

Effect of Elderberry (Sambucus nigra L.) Extract Supplementation in STZ-Induced Diabetic Rats Fed with a High-Fat Diet

Can lychee reducing the adipose tissue mass in rats?

The seed of Litchi chinensis fraction ameliorates hippocampal neuronal injury in an Aβ_25-35-induced Alzheimer’s disease rat model via the AKT/GSK-3β pathway

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Chemical composition and hypoglycaemic effect of polyphenol extracts from Litchi chinensis seeds

Cited by 42 publications

References 33 publications

Effect of Elderberry (Sambucus nigra L.) Extract Supplementation in STZ-Induced Diabetic Rats Fed with a High-Fat Diet

Effect of Elderberry (Sambucus nigra L.) Extract Supplementation in STZ-Induced Diabetic Rats Fed with a High-Fat Diet

Can lychee reducing the adipose tissue mass in rats?

The seed of Litchi chinensis fraction ameliorates hippocampal neuronal injury in an Aβ25-35-induced Alzheimer’s disease rat model via the AKT/GSK-3β pathway

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The seed of Litchi chinensis fraction ameliorates hippocampal neuronal injury in an Aβ_25-35-induced Alzheimer’s disease rat model via the AKT/GSK-3β pathway