Chemical Composition and Biological Properties of the Leaf Essential Oil of<i>Tagetes lucida</i>Cav. from Cuba

Regalado, Erik L.; Fernández, Miguel D.; Pino, Jorge A.; Mendiola, Judith; Echemendía, Olga

doi:10.1080/10412905.2011.9700485

Cited by 19 publications

(26 citation statements)

References 19 publications

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“…In the case of T. lucida Cav., the phytochemical studies of its essential oil were already reported after gas chromatography/mass spectrometry analysis. It is important to mention that the presence of methyl chavicol (estragole) was observed as a major constituent among other volatile compounds in T. lucida species, such as those cultivated in Guatemala (33.9%) [17], Costa Rica (95-97% aerial parts) [18], Italia (93.8% leaf and 78.2% flowers) [19], Cuba (96.8%) [10], Colombia (92.1%) [20], and Egypt (90%) [11]. However, this compound was not found in the T. lucida oil extracted from a species from Mexican regions, as corroborated in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Pharmacological and phytochemical studies of Tagetes lucida essential oil in terms of its antinociceptive and anti-inflammatory activities are lacking in literature. However, other properties were reported, such as its antibacterial, insecticidal [10,11], cytotoxic [12,13], and antioxidant activities [10]. Regarding the central nervous system (CNS), pharmacological studies reported antidepressant [14] and anxiolytic/sedative properties for this species [6].…”

Section: Introductionmentioning

confidence: 99%

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Role of β-Caryophyllene in the Antinociceptive and Anti-Inflammatory Effects of Tagetes lucida Cav. Essential Oil

et al. 2020

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Tagetes lucida Cav. (Asteraceae) is an ancient medicinal plant commonly used to alleviate pain. Nevertheless, scientific studies validating this property are lacking in the literature. Animal models of pain were used to evaluate the antinociceptive and anti-inflammatory activities of T. lucida essential oil (TLEO) and a bioactive metabolite. The chemical constitution and possible toxicity of the extract and the mechanism of action of β-caryophyllene were also explored. Temporal course curves and dose–response graphics were generated using TLEO (0.1–10 mg/kg or 3.16–31.62 mg/kg) and β-caryophyllene (3.16–10 mg/kg). Metamizole (80 mg/kg) and indomethacin (20 mg/kg) were used as reference drugs in the formalin assay and writhing test in rats and mice, respectively. The β-caryophyllene mechanism of action was explored in the presence of naloxone (1 mg/kg), flumazenil (10 mg/kg), WAY100635 (0.16 mg/kg), or nitro-l-arginine methyl ester (L-NAME) (20 mg/kg) in the formalin test in rats. GC/MS analysis demonstrated the presence of geranyl acetate (49.89%), geraniol (7.92%), and β-caryophyllene (6.27%). Significant and dose-dependent antinociceptive response was produced by TLEO and β-caryophyllene without the presence of gastric damage. In conclusion, β-caryophyllene was confirmed as a bioactive compound in the T. lucida analgesic properties by involving the participation of receptors like opioids, benzodiazepines, and Serotonin 1A receptor (5-HT1A), as well as nitric oxide.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of β-Caryophyllene in the Antinociceptive and Anti-Inflammatory Effects of Tagetes lucida Cav. Essential Oil

et al. 2020

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“…El acetato de geranilo (40.8%) fue el más abundante en el aceite esencial de la población Ixtapan de T. lucida (Cuadro 1), este compuesto no se había reportado en poblaciones de Guatemala, Cuba, Costa Rica y México (Bicchi et al, 1997;Cicció, 2004;Serrato et al, 2007;Regalado et al, 2011); a esta molécula y al nerolidol se les atribuye actividad tóxica contra larvas de Aedes aegypti (Muñoz et al, 2014), pero no se tenía referencia de su efecto contra nematodos. El compuesto β-ocimeno (15.14 %) posee propiedades antibióticas, anti-inflamatorias y anti-oxidantes, también destaca su efecto contra patógenos y protege a las plantas contra insectos plaga (Adorjan y Buchbauer, 2010), pero sin antecedentes contra nematodos.…”

Section: Discussionunclassified

“…Este metabolito secundario, del grupo de los fenilpropanoides, se ha identificado como un compuesto en alto porcentaje (96.8% y 97.3%) para poblaciones de Cuba (Regalado et al, 2011) y de Costa Rica (Cicció, 2004), respectivamente; no obstante, además del estragol, se reportan otros fenilpropanoides mayoritarios en muestras de pericón de Guatemala, como el anetol y el metil eugenol (Bicchi et al, 1997). La caracterización química de este recurso natural de México no se ha explorado suficientemente (Serrato, 2014).…”

Section: Introductionunclassified

Concentraciones e intervalos de aplicación del aceite esencial de Tagetes lucida Cav. contra Nacobbus aberrans

Zarate-Escobedo

Castaneda-Gonzalez²,

Cuevas-Sánchez

et al. 2018

Remexca

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La escaza información sobre los efectos del aceite esencial de Tagetes lucida contra nematodos y la riqueza de poblaciones nativas de esta especie vegetal en algunas áreas en el Estado de México resultan condiciones favorables para derivar insumos naturales inocuos de esta especie que posibiliten enfrentar problemas de agallamiento por N. aberrans en la producción de jitomate. El objetivo de este estudio fue evaluar en condiciones de invernadero la aplicación de aceite de T. lucida de una población natural de Ixtapan de la Sal, Estado de México en la formación de agallas por N. aberrans en plántulas de jitomate. El aceite esencial se extrajo por hidrodestilación a nivel piloto con rendimiento en peso seco de 0.4% (mL 100 g-1) y se analizó por CG/EM identificando los compuestos mayoritarios siguientes: acetato de geranilo (40.8%), β-ocimeno (15.1%), nerolidol (8.1%), β-cubebeno (5.1%) y cariofileno (5.2%). Plántulas de jitomate en maceta se inocularon con N. aberrans (10 mL kg-1 de sustrato) y se les dosificaron concentraciones de aceite desde 0.01 hasta 10 mg mL-1, como tratamientos preventivos y de control, en intervalos de aplicación de aceite de 1, 2 y 3 semanas. La inhibición del agallamiento de la raíz fue consistente en el tratamiento de control (TC) que en el preventivo. En TC, concentraciones de aceite de 0.35 y 1 mg mL-1 produjeron 63 a 80% de inhibición del agallamiento y se obtuvieron valores de CL50 de 0.06 mg mL-1 para los intervalos 1 y 2, y de 0.13 mg mL-1 para el intervalo 3.

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“…Forty volatile compounds were identifi ed in the leaf essential oil, of which estragole (96.8 %) was the major constituent (Regalado et al 2011 ). The essential oil exhibited signifi cant antioxidant activities as evaluated by two different in-vitro assays (DPPH and TBARS), and signifi cant activities were evidenced.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Tagetes lucida

Lim¹

2013

Edible Medicinal and Non-Medicinal Plants

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Chemical Composition and Biological Properties of the Leaf Essential Oil ofTagetes lucidaCav. from Cuba

Cited by 19 publications

References 19 publications

Role of β-Caryophyllene in the Antinociceptive and Anti-Inflammatory Effects of Tagetes lucida Cav. Essential Oil

Role of β-Caryophyllene in the Antinociceptive and Anti-Inflammatory Effects of Tagetes lucida Cav. Essential Oil

Concentraciones e intervalos de aplicación del aceite esencial de Tagetes lucida Cav. contra Nacobbus aberrans

Tagetes lucida

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