Chemical Composition and Biological Activity of Salicornia fruticosa L.

Abstract

P LANTS have been used as a source of traditional medicine to treat many diseases and conditions for many years. They considered as excellent source of phytochemicals which showed antioxidant and anticancer activities. The aim of the present study is to investigate the chemical composition and to determine the anticancer activity of Salicornia fruticosa (Chenopodiaceae) methanolic extract. S. fruticosa proved to be a source of isorhamnetin and its glycosides and showed anticancer activities. Seven major flavonoids were isolated and identified from the cytotoxic methanolic extract. The isolated compounds were identified, as quercetin 3',4'-dimethyl ether (1), isorhamnetin (2), isorhamnetin 3-O-rhamnoside (3), isorhamnetin 3-O-glucoside (4), isorhamnetin 3-O-rutinoside (5), isorhamnetin 3-O-neohesperidoside (6), isorhamnetin 3-O-rhamnosyl(1-2)arabinoside (7), by chromatographic analysis, chemical and spectroscopic tools (acid hydrolysis, UV, 1 H and 13 C NMR). Compounds 1 and 3-7 were isolated for the first time from the plant under investigation. The evaluation of cytotoxic activity of the methanolic extract against HCT-116, HepG2, A549 and MCF-7 human cancer cells, by MTT assay, revealed the higher potency of S. Fruticosa extract with IC 50 [2.6. 10.9, 37.9, 5.4 (mg/ml)] respectively, comparable to that of doxorubicin. The obtained results suggested that the investigated plant could be used for future development of naturally occurring anticancer agent. Subclinical and clinical trials on polar fractions of S. fruticosa are mandatory to pave the way for its use in treatment of cancer diseases (HCT-116, HepG2, A549 and MCF-7).

Preparation, Characterization and In vitro Biological activity of 5-Fluorouracil Loaded onto poly (D, L-lactic-co-glycolic acid) Nanoparticles

“…The antiproliferative activities on the HepG-2, HCT-116, MCF-7 and BJ-1 were estimated by the 3-[4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. This test is based on MTT cleavage by mitochondrial dehydrogenases form viable cells [35][36][37]. Cells were placed in a 96 well sterile microplate (5 × 10 4 cells well −1 ) and incubated at 37 °C in serum-free media containing dimethyl sulfoxide (DMSO) and either a series of various concentrations of each compound or doxorubicin (positive control) for 48 h before the MTT assay.…”

The Valuable Medicinal Plants of Northeast India: Illicium griffithii Hook. f., Pothos scandens L. and Sarcostemma acidum (Roxb.) Voigt

“…2,3 Natural product chemists are impressed by the fact that active biomolecules display an unbelievable range of diversity in terms of their structure as well as their biological and physical characteristics. 4,5 Due to both climatic and geographical variations, the Sub-Himalayan region of Northeast India is endowed with vast flora and fauna. 6 The ethnic people of this region are widely relying on these widely available natural sources for various health remedies.…”

Antimicrobial Compound Isolated From The Plant Pothos scandens L.

“…Medicinal plants have been utilized as a source of medicine to treat numerous diseases and disorders since time immemorial [1][2][3]. The most of world's population in developing countries rely on medicinal plants for their primary health care [4][5]. India has a rich tradition of using medicinal plants for the treatment of various infectious diseases, inflammations, injuries and other diseases [6].…”

“…P. scandens is an epiphyte with climbing and rooting branches. Its leaves are (5)(6)(7)(8)(9)(10) x (1-5) cm, distichous, ovate or ovate-lanceolate, acute or acumidate, obliquely linear with broad flat truncate petiole, sheathing at the base, having a bright green colour. The fruits or berries are 1.3-1.7 cm long and oblong and when ripe they become scarlet.…”