Natural substances are increasingly used now‐a‐days in organic syntheses for their safety aspects towards the environment. We have identified a natural substance which can promote organic reaction and can be sustainable as it can be obtained from plant sources. The natural substance can promote the synthesis of imidazole and dihydropyrimidine derivatives under solvent‐free condition. The method is economical, greener, metal and solvent free for the synthesis of highly functionalized imidazole and dihydropyrimidine derivatives and was promoted by water extract of pomelo (WEP) at room temperature. These WEP promoted reactions are found to afford high yield for the desired products and can be an alternative protocol for the existing procedures.
Elsholtzia communis (Collett & Hemsl.) Diels (family: Lamiaceae) is a wild edible plant employed as a remedy for skin irritation and consumed as vegetables by the indigenous tribes of North East, India. In view of its traditional uses, our present study aims to characterize the chemical constituents of the essential oil isolated from the leaf of E communis and evaluate its antimicrobial, cytotoxic, antioxidant and angiotensin-Iconverting enzyme inhibiting properties. GC-FID and GC-MS analyses of the essential oil led to the identification of fifty-one compounds with a yield of 0.88% (v/w). 71.72% of compounds are identified under the category of oxygenated monoterpenes, where neral (28.85%) and geranial (24.1%) were the most prevalent compounds.Ethyl geranate (4.82%), methyl nerate (4.71%), piperitone (4.07%) and caryophyllene oxide (3.75%) were other major constituents of the oil. The oil displayed excellent antifungal properties against C albicans with MIC value of 7.5 ± 0.13 µg/ mL, comparable with that of fluconazole (7.5 ± 0.25 µg/mL). Cytotoxic assay of the essential oil disclosed significant results with IC 50 value of 8.09 ± 2.67 µg/mL and 26.13 ± 0.90 µg/mL against HeLa and L6 cell lines, respectively. DPPH scavenging capability was assessed using ascorbic acid (1.57 ± 0.001 µg/mL) as reference. The result explicates promising antioxidant behaviour of the oil (21.92 ± 0.074 µg/mL).The oil (23.82 ± 0.078 µg/mL) was also found to possess potential ACE inhibitory effects, with ramipril (9.35 ± 0.02 µg/mL) serving as standard. The diverse pharmacological properties of the essential oil truly justify its traditional uses.
Pothos scandens L. is a medicinal plant found in North East India with various ethno-medicinal activities. A compound was isolated from the bark of P. scandens and the structure was characterized as Octyl isonicotinate (1) by extensive NMR, FT-IR and mass analysis. Compound 1 exhibited significant antimicrobial activity against Escherichia coli and Candida albicans by Agar well diffusion method with zone of inhibition value of 9.16±0.28 mm and 12.5±0.51 mm, respectively compared with standards Amikacin (19.33±0.57 mm) and Fluconazole (15.9±0.12 mm). The minimum inhibitory concentration (MIC) values were found 12.30 µg/mL and 6.50 µg/mL respectively as compared to Amikacin (4.37 µg/mL) and Fluconazole (7.5µg/mL).
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