Chemical composition and antioxidant, antibacterial, allelopathic and insecticidal activities of essential oil of Thymus algeriensis Boiss. et Reut.

Ali, Imran; Chaouachi, Maher; Bahri, Radhia; Chaieb, Ikbal; Boussaïd, Mohamed; Harzallah‐Skhiri, Fethia

doi:10.1016/j.indcrop.2015.09.046

Cited by 78 publications

(34 citation statements)

References 31 publications

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“…The identification of the OE constituents was done by calculating the retention time obtained in the analyzes of GC-MS, correlating them with the retention times of the n-alkanes (C9-C30). The indices were compared with the data available in the NIST / WILEY library [ 18 ]. The zerumbone identification was done as previously described [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

Zerumbone from Zingiber zerumbet (L.) smith: a potential prophylactic and therapeutic agent against the cariogenic bacterium Streptococcus mutans

Silva

Pinheiro

Orlandi

et al. 2018

BMC Complement Altern Med

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BackgroundEssential oil obtained from rhizomes of the Zingiber zerumbet (L.) Smith (popularly known in Brazil as bitter ginger) is mainly constituted by the biomolecule zerumbone, which exhibit untapped antimicrobial potential. The aim of this study was to investigate the antimicrobial activity of the zerumbone from bitter ginger rhizomes against the cariogenic agent Streptococcus mutans.MethodsFirstly, the essential oil from rhizomes of Zingiber zerumbet (L.) Smith extracted by hydrodistillation was submitted to purification and recrystallization process to obtain the zerumbone compound. The purity of zerumbone was determined through high-performance liquid chromatography analysis. Different concentrations of zerumbone were tested against the standard strain S. mutans (ATCC 35668) by using microdilution method. The speed of cidal activity was determined through a time kill-curve assay. The biological cytotoxicity activity of zerumbone was assessed using Vero cell line through MTT assay.ResultsThe zerumbone showed a minimum inhibitory concentration (MIC) of 250 μg/mL and a minimum bactericidal concentration (MBC) of 500 μg/mL against S. mutans. After six hours of bacteria-zerumbone interaction, all concentrations tested starts to kill the bacteria and all bacteria were killed between 48 and 72 h period at the concentration of 500 μg/mL (99,99% of bacteria were killed in comparison with original inoculum). In addition, zerumbone showed no cytotoxicity activity on mammalian continuous cells line.ConclusionsThese results draw attention to the potential of zerumbone as antimicrobial agent against S. mutans infection, indicating its possible use in the phyto-pharmaceutical formulations as new approach to prevent and treat tooth decay disease.Electronic supplementary materialThe online version of this article (10.1186/s12906-018-2360-0) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Zerumbone from Zingiber zerumbet (L.) smith: a potential prophylactic and therapeutic agent against the cariogenic bacterium Streptococcus mutans

Silva

Pinheiro

Orlandi

et al. 2018

BMC Complement Altern Med

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“…Certain allelochimic compounds have been shown to be effective as herbicides. EOs of aromatic plants are explored to find out possible herbicides, since they do not persist in soil or contaminate the ground water and cause little or no mammalian toxicity [ 29 ]. The inhibition ability of EOs belonging to Lamiaceae family (lavender and peppermint) against weed germination ( Amarantus retroflexus L., Sinapis arvensis L., Lolium perenne L.) has been previously reported.…”

Section: Introductionmentioning

confidence: 99%

Synergistic Antifungal, Allelopatic and Anti-Proliferative Potential of Salvia officinalis L., and Thymus vulgaris L. Essential Oils

et al. 2018

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The current study aimed to investigate the chemical composition and the synergistic potential of two essential oils (EOs), as obtained from Salvia officinalis L. (SEO), and Thymus vulgaris L. (TEO). The antifungal potential was tested in vitro against Fusarium graminearum (Fg 06_17), the herbicidal effect was studied using weed seeds of Amaranthus retroflexus (ARET), Chenopodium album (CALB), Echinochloa crus-galli (EGAL), but also wheat seeds (WS) of the Lovrin variety and tomato seeds Saint-Pierre of the variety. The GC-MS profile highlights that the mains compounds identified in SEO were: caryophyllene (25.364%), camphene (14.139%), eucalyptol (13.902%), and β-pinene (11.230%), while in TEO, the predominant phytochemicals were: γ-terpinene (68.415%) and p-thymol (24.721%). The results indicated that the tested EOs alone as well as in combination have allelopathic effect against investigated seeds, while the synergistic effect of TEO and SEO in terms of fungal growth was demonstrated at a level of 0.06%. Thyme and sage EOs exhibited in vitro anti-proliferative activity on two melanoma cell lines, namely A375 human melanoma and B164A5 mouse melanoma alone, as well as in combination. SEO was most effective in terms of decreasing the cell viability of murine and human melanoma cell lines when compared to TEO.

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“…Previous studies indicated that the chemotype germacrene D has deterrent effects against herbivores and insecticidal activity against mosquitoes as well as repellent activity against aphids (Noge & Becerra, ). Moreover, β ‐caryophyllene, which is also one of the main constituents, possesses a high toxic effect against cotton aphid, Aphis gossypii (LD 50 reached 0.65 10 −1 μg per individual; Ben El Hadj Ali et al, ). Thus, a chromatographic study is necessary to identify the main bioactive compounds and to focus on their mechanisms of action.…”

Section: Discussionmentioning

confidence: 99%

Chromatographic analysis, antimicrobial and insecticidal activities of the essential oil of Phlomis floccosa D. Don.

Mokni

Majdoub

Chaieb

et al. 2019

Biomedical Chromatography

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The present study was conducted to investigate for the first time the chemical composition and insecticidal and antimicrobial properties of Phlomis floccosa D. Don. essential oil isolated by hydro-distillation of its aerial parts. Qualitative and quantitative analyses of the essential oil on the basis of gas chromatography and mass spectrometry (GC/FID and GC/MS) revealed the presence of 59 organic volatiles representing 86.9% of the total constituents. The major compounds were germacrene-D (19.7%) followed by β-caryophyllene (15.5%), caryophyllene oxide (8.3%), hexadecenoic acid (7.9%) and carvacrol (6.1%). The broth microdilution method was conducted to test the antimicrobial activity of the essential oil against five pathogens: Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica, Staphylococcus aureus, Bacillus subtilis and the yeast Candida albicans. The oil of P. floccosa D. Don. shows promising activity against the Gram-positive bacteria S. aureus and B. subtilis and the yeast C. albicans (minimum inhibitory concentration = 625 μg.mL −1 ).The effectiveness of the essential oil was assessed on both Tribolium confusum and Sitophilus zeamais pest insects and it was more pronounced against T. confusum, showing a moderate mortality of 47.5%.

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Chemical composition and antioxidant, antibacterial, allelopathic and insecticidal activities of essential oil of Thymus algeriensis Boiss. et Reut.

Cited by 78 publications

References 31 publications

Zerumbone from Zingiber zerumbet (L.) smith: a potential prophylactic and therapeutic agent against the cariogenic bacterium Streptococcus mutans

Zerumbone from Zingiber zerumbet (L.) smith: a potential prophylactic and therapeutic agent against the cariogenic bacterium Streptococcus mutans

Synergistic Antifungal, Allelopatic and Anti-Proliferative Potential of Salvia officinalis L., and Thymus vulgaris L. Essential Oils

Chromatographic analysis, antimicrobial and insecticidal activities of the essential oil of Phlomis floccosa D. Don.

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